Search Results - "Stewart, Francis"

The Transcriptional and Epigenomic Foundations of Ground State Pluripotency by Marks, Hendrik, Kalkan, Tüzer, Menafra, Roberta, Denissov, Sergey, Jones, Kenneth, Hofemeister, Helmut, Nichols, Jennifer, Kranz, Andrea, Francis Stewart, A., Smith, Austin, Stunnenberg, Hendrik G.

“…Mouse embryonic stem (ES) cells grown in serum exhibit greater heterogeneity in morphology and expression of pluripotency factors than ES cells cultured in…”
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MLL1 is required for PAX7 expression and satellite cell self-renewal in mice by Addicks, Gregory C., Brun, Caroline E., Sincennes, Marie-Claude, Saber, John, Porter, Christopher J., Francis Stewart, A., Ernst, Patricia, Rudnicki, Michael A.

“…PAX7 is a paired-homeobox transcription factor that specifies the myogenic identity of muscle stem cells and acts as a nodal factor by stimulating…”
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MLL2 is required in oocytes for bulk histone 3 lysine 4 trimethylation and transcriptional silencing by Andreu-Vieyra, Claudia V, Chen, Ruihong, Agno, Julio E, Glaser, Stefan, Anastassiadis, Konstantinos, Stewart, A Francis, Matzuk, Martin M

“…During gametogenesis and pre-implantation development, the mammalian epigenome is reprogrammed to establish pluripotency in the epiblast. Here we show that the…”
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Loss of histone methyltransferase SETD1B in oogenesis results in the redistribution of genomic histone 3 lysine 4 trimethylation by Hanna, Courtney W, Huang, Jiahao, Belton, Christian, Reinhardt, Susanne, Dahl, Andreas, Andrews, Simon, Stewart, A Francis, Kranz, Andrea, Kelsey, Gavin

“…Abstract Histone 3 lysine 4 trimethylation (H3K4me3) is an epigenetic mark found at gene promoters and CpG islands. H3K4me3 is essential for mammalian…”
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Sustained Pax6 Expression Generates Primate-like Basal Radial Glia in Developing Mouse Neocortex by Wong, Fong Kuan, Fei, Ji-Feng, Mora-Bermúdez, Felipe, Taverna, Elena, Haffner, Christiane, Fu, Jun, Anastassiadis, Konstantinos, Stewart, A Francis, Huttner, Wieland B

“…The evolutionary expansion of the neocortex in mammals has been linked to enlargement of the subventricular zone (SVZ) and increased proliferative capacity of…”
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The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness by Grinat, Johanna, Heuberger, Julian, Vidal, Ramon Oliveira, Goveas, Neha, Kosel, Frauke, Berenguer-Llergo, Antoni, Kranz, Andrea, Wulf-Goldenberg, Annika, Behrens, Diana, Melcher, Bálint, Sauer, Sascha, Vieth, Michael, Batlle, Eduard, Stewart, A. Francis, Birchmeier, Walter

“…Wnt/β-catenin signaling is crucial for intestinal carcinogenesis and the maintenance of intestinal cancer stem cells. Here we identify the histone…”
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Jarid2 Is Implicated in the Initial Xist-Induced Targeting of PRC2 to the Inactive X Chromosome by da Rocha, Simão Teixeira, Boeva, Valentina, Escamilla-Del-Arenal, Martin, Ancelin, Katia, Granier, Camille, Matias, Neuza Reis, Sanulli, Serena, Chow, Jen, Schulz, Edda, Picard, Christel, Kaneko, Syuzo, Helin, Kristian, Reinberg, Danny, Stewart, A. Francis, Wutz, Anton, Margueron, Raphaël, Heard, Edith

“…During X chromosome inactivation (XCI), the Polycomb Repressive Complex 2 (PRC2) is thought to participate in the early maintenance of the inactive state…”
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Neuronal Kmt2a/Mll1 histone methyltransferase is essential for prefrontal synaptic plasticity and working memory by Jakovcevski, Mira, Ruan, Hongyu, Shen, Erica Y, Dincer, Aslihan, Javidfar, Behnam, Ma, Qi, Peter, Cyril J, Cheung, Iris, Mitchell, Amanda C, Jiang, Yan, Lin, Cong L, Pothula, Venu, Stewart, A Francis, Ernst, Patricia, Yao, Wei-Dong, Akbarian, Schahram

“…Neuronal histone H3-lysine 4 methylation landscapes are defined by sharp peaks at gene promoters and other cis-regulatory sequences, but molecular and cellular…”
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The Set1 complex is dimeric and acts with Jhd2 demethylation to convey symmetrical H3K4 trimethylation by Choudhury, Rupam, Singh, Sukhdeep, Arumugam, Senthil, Roguev, Assen, Stewart, A Francis

“…Epigenetic modifications can maintain or alter the inherent symmetry of the nucleosome. However, the mechanisms that deposit and/or propagate symmetry or…”
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A conditional knockout resource for the genome-wide study of mouse gene function by Skarnes, William C., Rosen, Barry, West, Anthony P., Koutsourakis, Manousos, Bushell, Wendy, Iyer, Vivek, Mujica, Alejandro O., Thomas, Mark, Harrow, Jennifer, Cox, Tony, Jackson, David, Severin, Jessica, Biggs, Patrick, Fu, Jun, Nefedov, Michael, de Jong, Pieter J., Stewart, A. Francis, Bradley, Allan

“…Gene targeting in embryonic stem cells has become the principal technology for manipulation of the mouse genome, offering unrivalled accuracy in allele design…”
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Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting by Fu, Jun, Bian, Xiaoying, Hu, Shengbaio, Wang, Hailong, Huang, Fan, Seibert, Philipp M, Plaza, Alberto, Xia, Liqiu, Müller, Rolf, Stewart, A Francis, Zhang, Youming

“…Functional genomics requires facile methods to recover sequences of interest. Fu et al . show that the phage proteins RecE and RecT mediate recombination…”
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Mll2 is required for H3K4 trimethylation on bivalent promoters in embryonic stem cells, whereas Mll1 is redundant by Denissov, Sergei, Hofemeister, Helmut, Marks, Hendrik, Kranz, Andrea, Ciotta, Giovanni, Singh, Sukhdeep, Anastassiadis, Konstantinos, Stunnenberg, Hendrik G, Stewart, A Francis

“…Trimethylation of histone H3 lysine 4 (H3K4me3) at the promoters of actively transcribed genes is a universal epigenetic mark and a key product of Trithorax…”
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Direct cloning and heterologous expression of the salinomycin biosynthetic gene cluster from Streptomyces albus DSM41398 in Streptomyces coelicolor A3(2) by Yin, Jia, Hoffmann, Michael, Bian, Xiaoying, Tu, Qiang, Yan, Fu, Xia, Liqiu, Ding, Xuezhi, Francis Stewart, A., Müller, Rolf, Fu, Jun, Zhang, Youming

“…Linear plus linear homologous recombination-mediated recombineering (LLHR) is ideal for obtaining natural product biosynthetic gene clusters from pre-digested…”
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Setd1b , encoding a histone 3 lysine 4 methyltransferase, is a maternal effect gene required for the oogenic gene expression program by Brici, David, Zhang, Qinyu, Reinhardt, Susanne, Dahl, Andreas, Hartmann, Hella, Schmidt, Kerstin, Goveas, Neha, Huang, Jiahao, Gahurova, Lenka, Kelsey, Gavin, Anastassiadis, Konstantinos, Stewart, A Francis, Kranz, Andrea

“…Germ cell development involves major reprogramming of the epigenome to prime the zygote for totipotency. Histone 3 lysine 4 (H3K4) methylations are universal…”
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New methods for extracting function from the mammalian genome by Francis Stewart, A., von Melchner, Harald

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RedEx: a method for seamless DNA insertion and deletion in large multimodular polyketide synthase gene clusters by Song, Chaoyi, Luan, Ji, Li, Ruijuan, Jiang, Chanjuan, Hou, Yu, Cui, Qingwen, Cui, Tianqi, Tan, Long, Ma, Zaichao, Tang, Ya-Jie, Stewart, A Francis, Fu, Jun, Zhang, Youming, Wang, Hailong

“…Abstract Biosynthesis reprograming is an important way to diversify chemical structures. The large repetitive DNA sequences existing in polyketide synthase…”
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Meiotic DNA double-strand breaks and chromosome asynapsis in mice are monitored by distinct HORMAD2-independent and -dependent mechanisms by Wojtasz, Lukasz, Cloutier, Jeffrey M, Baumann, Marek, Daniel, Katrin, Varga, János, Fu, Jun, Anastassiadis, Konstantinos, Stewart, A Francis, Reményi, Attila, Turner, James M A, Tóth, Attila

“…Meiotic crossover formation involves the repair of programmed DNA double-strand breaks (DSBs) and synaptonemal complex (SC) formation. Completion of these…”
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A Genome-Scale Resource for In Vivo Tag-Based Protein Function Exploration in C. elegans by Sarov, Mihail, Murray, John I., Schanze, Kristin, Pozniakovski, Andrei, Niu, Wei, Angermann, Karolin, Hasse, Susanne, Rupprecht, Michaela, Vinis, Elisabeth, Tinney, Matthew, Preston, Elicia, Zinke, Andrea, Enst, Susanne, Teichgraber, Tina, Janette, Judith, Reis, Kadri, Janosch, Stephan, Schloissnig, Siegfried, Ejsmont, Radoslaw K., Slightam, Cindie, Xu, Xiao, Kim, Stuart K., Reinke, Valerie, Stewart, A. Francis, Snyder, Michael, Waterston, Robert H., Hyman, Anthony A.

“…Understanding the in vivo dynamics of protein localization and their physical interactions is important for many problems in biology. To enable systematic…”
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The H3K4 methyltransferase Setd1a is first required at the epiblast stage, whereas Setd1b becomes essential after gastrulation by Bledau, Anita S, Schmidt, Kerstin, Neumann, Katrin, Hill, Undine, Ciotta, Giovanni, Gupta, Ashish, Torres, Davi Coe, Fu, Jun, Kranz, Andrea, Stewart, A Francis, Anastassiadis, Konstantinos

“…Histone 3 lysine 4 (H3K4) methylation is a universal epigenetic mark. In mammals, there are six H3K4 methyltransferases related to yeast Set1 and fly…”
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Improved seamless mutagenesis by recombineering using ccdB for counterselection by Wang, Hailong, Bian, Xiaoying, Xia, Liqiu, Ding, Xuezhi, Müller, Rolf, Zhang, Youming, Fu, Jun, Stewart, A Francis

“…Recombineering, which is the use of homologous recombination for DNA engineering in Escherichia coli, usually uses antibiotic selection to identify the…”
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