Search Results - "Stewart, Fay"

Ex vivo modelling of PD-1/PD-L1 immune checkpoint blockade under acute, chronic, and exhaustion-like conditions of T-cell stimulation by Roberts, Alexander, Bentley, Lindsay, Tang, Tina, Stewart, Fay, Pallini, Chiara, Juvvanapudi, Joel, Wallace, Graham R., Cooper, Alison J., Scott, Aaron, Thickett, David, Lugg, Sebastian T., Bancroft, Hollie, Hemming, Bridget, Ferris, Charlotte, Langman, Gerald, Robinson, Andrew, Chapman, Joanne, Naidu, Babu, Pinkney, Thomas, Taylor, Graham S., Brock, Kristian, Stamataki, Zania, Brady, Catherine A., Curnow, S. John, Gordon, John, Qureshi, Omar, Barnes, Nicholas M.

“…Blockade of PD-1/PD-L1 interactions is proving an exciting, durable therapeutic modality in a range of cancers whereby T cells are released from checkpoint…”
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Impact of a varied set of stimuli on a suite of immunological parameters within peripheral blood mononuclear cells: toward a non-animal approach for assessing immune modulation by materials intended for human use by Cochrane, Stella, Rajagopal, Ramya, Sheffield, David, Stewart, Fay, Hathaway, Lindsay, Barnes, Nicholas M, Qureshi, Omar, Gordon, John

“…In toxicology, steps are being taken towards more mechanism-focused and human relevant approaches to risk assessment, requiring new approaches and methods…”
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Abstract 622: Differential impact of pembrolizumab and ipilimumab on IFNgamma and IL-10 production from in-vitro monocyte-derived DC and T cell co-cultures by Tang, Tina, Stewart, Fay, Roberts, Alexander, Gordon, John, Curnow, John, Barnes, Nicholas, Qureshi, Omar

“…Despite the success with checkpoint inhibitors in-vivo, demonstrating efficacy in-vitro using human primary immune cells remains a challenge. Our aim was to…”
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Abstract 3274: A robust enhancement of cytokine production in a human chronic activation model of T cell exhaustion in vitro through blockade of PD-1/PDL-1 interactions using pembrolizumab or nivolumab; correlation with dissociated tumor immune cell responses by Qureshi, Omar S., Roberts, Alexander, Bentley, Lindsay, Tang, Tina, Stewart, Fay, Wallace, Graham, Cooper, Alison, Scott, Aaron, Thickett, David, Naidu, Babu, Pinkney, Thomas, Taylor, Graham, Brock, Kristian, Healy, Louise, Stamataki, Zania, Brady, Catherine, Curnow, S J., Gordon, John, Barnes, Nicholas M.

“…Prolonged exposure to antigens can lead to a state of reduced T cell responsiveness termed exhaustion. Restoring T cell functions from this state of reduced…”
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You told us by Stewart, Fay, Breslau, Ellen

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Why Piccadilly? The Story of the Names of London by R., J. H., Fay, E. Stewart

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