Effect of variable power levels on the yield of total aerosol mass and formation of aldehydes in e-cigarette aerosols

The study objective was to determine the effect of variable power applied to the atomizer of refillable tank based e-cigarette (EC) devices. Five different devices were evaluated, each at four power levels. Aerosol yield results are reported for each set of 25 EC puffs, as mass/puff, and normalized...

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Bibliographic Details
Published in:	Regulatory toxicology and pharmacology Vol. 75; pp. 58 - 65
Main Authors:	Gillman, I.G., Kistler, K.A., Stewart, E.W., Paolantonio, A.R.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 01-03-2016
Subjects:	2,4-DNPH derivatives of aldehydes Acetaldehyde Acetaldehyde - analysis Acetaldehyde - standards Acrolein Acrolein - analysis Acrolein - standards Aerosols Air Pollutants - analysis Air Pollutants - standards Chemical composition Electronic Nicotine Delivery Systems Electronic-cigarettes Environmental Exposure - analysis Environmental Exposure - standards Formaldehyde Formaldehyde - analysis Formaldehyde - standards Liquid chromatography Toxicology Workplace - standards Acrolein Toxicology Electronic-cigarettes 2,4-DNPH derivatives of aldehydes Electronic nicotine delivery systems Liquid chromatography Chemical composition Formaldehyde Acetaldehyde
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Summary:	The study objective was to determine the effect of variable power applied to the atomizer of refillable tank based e-cigarette (EC) devices. Five different devices were evaluated, each at four power levels. Aerosol yield results are reported for each set of 25 EC puffs, as mass/puff, and normalized for the power applied to the coil, in mass/watt. The range of aerosol produced on a per puff basis ranged from 1.5 to 28 mg, and, normalized for power applied to the coil, ranged from 0.27 to 1.1 mg/watt. Aerosol samples were also analyzed for the production of formaldehyde, acetaldehyde, and acrolein, as DNPH derivatives, at each power level. When reported on mass basis, three of the devices showed an increase in total aldehyde yield with increasing power applied to the coil, while two of the devices showed the opposite trend. The mass of formaldehyde, acetaldehyde, and acrolein produced per gram of total aerosol produced ranged from 0.01 to 7.3 mg/g, 0.006 to 5.8 mg/g, and <0.003 to 0.78 mg/g, respectively. These results were used to estimate daily exposure to formaldehyde, acetaldehyde, and acrolein from EC aerosols from specific devices, and were compared to estimated exposure from consumption of cigarettes, to occupational and workplace limits, and to previously reported results from other researchers. •Five, variable power, e-cigarettes devices were evaluated for aerosol yield and formation of aldehydes in the aerosol.•The mass of aerosol produced, on a per puff basis, ranged from 1.5 to 28 mg.•750-fold difference in total aldehyde yield between the devices evaluated.•Range of aerosol produced per puff, normalized for power applied to the coil, ranged from 0.27 to 1.1 mg/watt.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0273-2300 1096-0295
DOI:	10.1016/j.yrtph.2015.12.019