Search Results - "Stewart, Alastair G."

Endothelial Dysfunction in Atherosclerotic Cardiovascular Diseases and Beyond: From Mechanism to Pharmacotherapies by Xu, Suowen, Ilyas, Iqra, Little, Peter J., Li, Hong, Kamato, Danielle, Zheng, Xueying, Luo, Sihui, Li, Zhuoming, Liu, Peiqing, Han, Jihong, Harding, Ian C., Ebong, Eno E., Cameron, Scott J., Stewart, Alastair G., Weng, Jianping

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Non-Alcoholic Steatohepatitis: A Review of Its Mechanism, Models and Medical Treatments by Peng, Cheng, Stewart, Alastair G, Woodman, Owen L, Ritchie, Rebecca H, Qin, Cheng Xue

“…Non-alcoholic steatohepatitis (NASH) develops from non-alcoholic fatty liver disease (NAFLD). Currently, around 25% of the population is estimated to have…”
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The six steps of the complete F1-ATPase rotary catalytic cycle by Sobti, Meghna, Ueno, Hiroshi, Noji, Hiroyuki, Stewart, Alastair G.

“…F 1 F o ATP synthase interchanges phosphate transfer energy and proton motive force via a rotary catalysis mechanism. Isolated F 1 -ATPase catalytic cores can…”
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Cryo-EM structures provide insight into how E. coli F1Fo ATP synthase accommodates symmetry mismatch by Sobti, Meghna, Walshe, James L., Wu, Di, Ishmukhametov, Robert, Zeng, Yi C., Robinson, Carol V., Berry, Richard M., Stewart, Alastair G.

“…F 1 F o ATP synthase functions as a biological rotary generator that makes a major contribution to cellular energy production. It comprises two molecular…”
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Protein assemblies ejected directly from native membranes yield complexes for mass spectrometry by Chorev, Dror S, Baker, Lindsay A, Wu, Di, Beilsten-Edmands, Victoria, Rouse, Sarah L, Zeev-Ben-Mordehai, Tzviya, Jiko, Chimari, Samsudin, Firdaus, Gerle, Christoph, Khalid, Syma, Stewart, Alastair G, Matthews, Stephen J, Grünewald, Kay, Robinson, Carol V

“…Membrane proteins reside in lipid bilayers and are typically extracted from this environment for study, which often compromises their integrity. In this work,…”
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Cryo-EM structures of the autoinhibited E. coli ATP synthase in three rotational states by Sobti, Meghna, Smits, Callum, Wong, Andrew Sw, Ishmukhametov, Robert, Stock, Daniela, Sandin, Sara, Stewart, Alastair G

“…A molecular model that provides a framework for interpreting the wealth of functional information obtained on the F-ATP synthase has been generated using…”
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Machine learning enables pan-cancer identification of mutational hotspots at persistent CTCF binding sites by Chen, Wenhan, Zeng, Yi C, Achinger-Kawecka, Joanna, Campbell, Elyssa, Jones, Alicia K, Stewart, Alastair G, Khoury, Amanda, Clark, Susan J

“…Abstract CCCTC-binding factor (CTCF) is an insulator protein that binds to a highly conserved DNA motif and facilitates regulation of three-dimensional (3D)…”
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ATP Synthase: Expression, Purification, and Function by Sobti, Meghna, Ishmukhametov, Robert, Stewart, Alastair G

“…ATP synthase is an essential enzyme found in all known forms of life, generating the majority of cellular energy via a rotary catalytic mechanism. Here, we…”
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Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice by Qin, Cheng Xue, May, Lauren T., Li, Renming, Cao, Nga, Rosli, Sarah, Deo, Minh, Alexander, Amy E., Horlock, Duncan, Bourke, Jane E., Yang, Yuan H., Stewart, Alastair G., Kaye, David M., Du, Xiao-Jun, Sexton, Patrick M., Christopoulos, Arthur, Gao, Xiao-Ming, Ritchie, Rebecca H.

“…Effective treatment for managing myocardial infarction (MI) remains an urgent, unmet clinical need. Formyl peptide receptors (FPR) regulate inflammation, a…”
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Structural basis of promiscuous substrate transport by Organic Cation Transporter 1 by Zeng, Yi C., Sobti, Meghna, Quinn, Ada, Smith, Nicola J., Brown, Simon H. J., Vandenberg, Jamie I., Ryan, Renae M., O’Mara, Megan L., Stewart, Alastair G.

“…Organic Cation Transporter 1 (OCT1) plays a crucial role in hepatic metabolism by mediating the uptake of a range of metabolites and drugs. Genetic variations…”
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Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients by Rouet, Romain, Henry, Jake Y., Johansen, Matt D., Sobti, Meghna, Balachandran, Harikrishnan, Langley, David B., Walker, Gregory J., Lenthall, Helen, Jackson, Jennifer, Ubiparipovic, Stephanie, Mazigi, Ohan, Schofield, Peter, Burnett, Deborah L., Brown, Simon H. J., Martinello, Marianne, Hudson, Bernard, Gilroy, Nicole, Post, Jeffrey J., Kelleher, Anthony, Jäck, Hans-Martin, Goodnow, Christopher C., Turville, Stuart G., Rawlinson, William D., Bull, Rowena A., Stewart, Alastair G., Hansbro, Philip M., Christ, Daniel

“…Emerging variants of concern (VOCs) are threatening to limit the effectiveness of SARS-CoV-2 monoclonal antibodies and vaccines currently used in clinical…”
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Ion mobility–mass spectrometry of a rotary ATPase reveals ATP-induced reduction in conformational flexibility by Zhou, Min, Politis, Argyris, Davies, Roberta B., Liko, Idlir, Wu, Kuan-Jung, Stewart, Alastair G., Stock, Daniela, Robinson, Carol V.

“…Rotary ATPases play fundamental roles in energy conversion as their catalytic rotation is associated with interdomain fluctuations and heterogeneity of…”
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Cryo-EM reveals distinct conformations of E. coli ATP synthase on exposure to ATP by Sobti, Meghna, Ishmukhametov, Robert, Bouwer, James C, Ayer, Anita, Suarna, Cacang, Smith, Nicola J, Christie, Mary, Stocker, Roland, Duncan, Thomas M, Stewart, Alastair G

“…ATP synthase produces the majority of cellular energy in most cells. We have previously reported cryo-EM maps of autoinhibited ATP synthase imaged without…”
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Cardioprotective potential of annexin-A1 mimetics in myocardial infarction by Qin, Chengxue, Yang, Yuan H, May, Lauren, Gao, Xiaoming, Stewart, Alastair G, Tu, Yan, Woodman, Owen L, Ritchie, Rebecca H

“…Myocardial infarction (MI) and its resultant heart failure remains a major cause of death in the world. The current treatments for patients with MI are…”
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Potassium dependent structural changes in the selectivity filter of HERG potassium channels by Lau, Carus H. Y., Flood, Emelie, Hunter, Mark J., Williams-Noonan, Billy J., Corbett, Karen M., Ng, Chai-Ann, Bouwer, James C., Stewart, Alastair G., Perozo, Eduardo, Allen, Toby W., Vandenberg, Jamie I.

“…The fine tuning of biological electrical signaling is mediated by variations in the rates of opening and closing of gates that control ion flux through…”
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Cellular Biomechanics in Drug Screening and Evaluation: Mechanopharmacology by Krishnan, Ramaswamy, Park, Jin-Ah, Seow, Chun Y, Lee, Peter V-S, Stewart, Alastair G

“…The study of mechanobiology is now widespread. The impact of cell and tissue mechanics on cellular responses is well appreciated. However, knowledge of the…”
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Editorial: Accelerated Translation Using Microphysiological Organoid and Microfluidic Chip Models by Benam, Kambez H, Burgess, Janette K, Stewart, Alastair G

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Rhythm on a chip: circadian entrainment in vitro is the next frontier in body-on-a chip technology by Fustin, Jean-Michel, Li, Meina, Gao, Bryan, Chen, Qianyu, Cheng, Tianhong, Stewart, Alastair G

“…[Display omitted] Organoids, bioprinted mini-tissues and body-on-a-chip technologies are poised to transform the practice of preclinical pharmacology, with a…”
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Glucocorticoid Insensitivity in Virally Infected Airway Epithelial Cells Is Dependent on Transforming Growth Factor-β Activity by Xia, Yuxiu C, Radwan, Asmaa, Keenan, Christine R, Langenbach, Shenna Y, Li, Meina, Radojicic, Danica, Londrigan, Sarah L, Gualano, Rosa C, Stewart, Alastair G

“…Asthma and chronic obstructive pulmonary disease (COPD) exacerbations are commonly associated with respiratory syncytial virus (RSV), rhinovirus (RV) and…”
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Anti-fibrotic strategies and pulmonary fibrosis by Gunatilaka, Avanka, Zhang, Stephanie, Tan, Wan Shun Daniel, G Stewart, Alastair

“…Idiopathic pulmonary fibrosis (IPF) results from the dysregulated process of injury and repair, which promotes scarring of the lung tissue and deposition of…”
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