Search Results - "Stewart, A. K"

Mechanism of action of immunomodulatory drugs (IMiDS) in multiple myeloma by Quach, H, Ritchie, D, Stewart, A K, Neeson, P, Harrison, S, Smyth, M J, Prince, H M

“…Immunomodulatory drugs (IMiDs) are thalidomide analogues, which possess pleiotropic anti-myeloma properties including immune-modulation, anti-angiogenic,…”
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Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice by Savonenko, A.V, Melnikova, T, Laird, F.M, Stewart, K.-A, Price, D.L, Wong, P.C

“…β-Site APP-cleaving enzyme 1 (BACE1) is required for the penultimate cleavage of the amyloid-β precursor protein (APP) leading to the generation of amyloid-β…”
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International Myeloma Working Group molecular classification of multiple myeloma: spotlight review by Fonseca, R, Bergsagel, P L, Drach, J, Shaughnessy, J, Gutierrez, N, Stewart, A K, Morgan, G, Van Ness, B, Chesi, M, Minvielle, S, Neri, A, Barlogie, B, Kuehl, W M, Liebisch, P, Davies, F, Chen-Kiang, S, Durie, B G M, Carrasco, R, Sezer, Orhan, Reiman, Tony, Pilarski, Linda, Avet-Loiseau, H

“…Myeloma is a malignant proliferation of monoclonal plasma cells. Although morphologically similar, several subtypes of the disease have been identified at the…”
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Cyclophosphamide, bortezomib and dexamethasone induction for newly diagnosed multiple myeloma: high response rates in a phase II clinical trial by Reeder, C B, Reece, D E, Kukreti, V, Chen, C, Trudel, S, Hentz, J, Noble, B, Pirooz, N A, Spong, J E, Piza, J G, Zepeda, V H J, Mikhael, J R, Leis, J F, Bergsagel, P L, Fonseca, R, Stewart, A K

“…We have studied a three-drug combination with cyclophosphamide, bortezomib and dexamethasone (CyBorD) on a 28-day cycle in the treatment of newly diagnosed…”
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Metagenomic shotgun sequencing of blood to identify bacteria and viruses in leukemic febrile neutropenia by Vijayvargiya, Prakhar, Feri, Adeline, Mairey, Mathilde, Rouillon, Cécile, Jeraldo, Patricio R, Esquer Garrigos, Zerelda, Thoendel, Matthew J, Greenwood-Quaintance, Kerryl E, Sohail, M Rizwan, Sampathkumar, Priya, Spychalla, Megan T, Stewart, A K, Patnaik, Mrinal M, Tande, Aaron J, Cruveiller, Stéphane, Hannet, Irene, Beurdeley, Pascale, Patel, Robin

“…Despite diagnostic advances in microbiology, the etiology of neutropenic fever remains elusive in most cases. In this study, we evaluated the utility of a…”
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Clinically relevant end points and new drug approvals for myeloma by Anderson, K C, Kyle, R A, Rajkumar, S V, Stewart, A K, Weber, D, Richardson, P

“…This manuscript summarizes the recommendations of the American Society of Hematology/US Food and Drug Administration Workshop on Clinical Endpoints in Multiple…”
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Genetic aberrations and survival in plasma cell leukemia by Tiedemann, R E, Gonzalez-Paz, N, Kyle, R A, Santana-Davila, R, Price-Troska, T, Van Wier, S A, Chng, W J, Ketterling, R P, Gertz, M A, Henderson, K, Greipp, P R, Dispenzieri, A, Lacy, M Q, Rajkumar, S V, Bergsagel, P L, Stewart, A K, Fonseca, R

“…Plasma cell leukemia (PCL) is an aggressive and rare hematological malignancy that originates either as primary disease (pPCL) or as a secondary leukemic…”
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Pomalidomide (CC4047) plus low dose dexamethasone (Pom dex) is active and well tolerated in lenalidomide refractory multiple myeloma (MM) by Lacy, M Q, Hayman, S R, Gertz, M A, Short, K D, Dispenzieri, A, Kumar, S, Greipp, P R, Lust, J A, Russell, S J, Dingli, D, Zeldenrust, S, Fonseca, R, Bergsagel, P L, Roy, V, Mikhael, J R, Stewart, A K, Laumann, K, Allred, J B, Mandrekar, S J, Rajkumar, S V, Buadi, F

“…Patients with multiple myeloma progressing on current therapies have limited treatment options. Pomalidomide (CC4047), an immunomodulatory drug, has…”
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The role of genetic diversity in the evolution and maintenance of environmentally-cued, male alternative reproductive tactics by Stewart, K A, Draaijer, R, Kolasa, M R, Smallegange, I M

“…Alternative reproductive tactics (ARTs) are taxonomically pervasive strategies adopted by individuals to maximize reproductive success within populations. Even…”
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Germline Cancer Testing in Unselected Patients with Gastric and Esophageal Cancers: A Multi-center Prospective Study by Uson, P. L. S., Kunze, K. L., Golafshar, M. A., Botrus, G., Riegert-Johnson, D., Boardman, L., Borad, M. J., Ahn, D., Sonbol, M. B., Kahn, A., Klint, M., Esplin, E. D., Nussbaum, R. L., Stewart, A. K., Bekaii-Saab, T., Samadder, N. J.

“…Background and Aims To determine prevalence and clinical utility of pathogenic germline variants (PGV) in gastric and esophageal cancer patients using…”
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Genome-wide studies in multiple myeloma identify XPO1/CRM1 as a critical target validated using the selective nuclear export inhibitor KPT-276 by Schmidt, J, Braggio, E, Kortuem, K M, Egan, J B, Zhu, Y X, Xin, C S, Tiedemann, R E, Palmer, S E, Garbitt, V M, McCauley, D, Kauffman, M, Shacham, S, Chesi, M, Bergsagel, P L, Stewart, A K

“…RNA interference screening identified XPO1 (exportin 1) among the 55 most vulnerable targets in multiple myeloma (MM). XPO1 encodes CRM1, a nuclear export…”
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A practical guide to defining high-risk myeloma for clinical trials, patient counseling and choice of therapy by STEWART, A. K, BERGSAGEL, P. L, WITZIG, T. E, ZELDENRUST, S. R, DINGLI, D, REEDER, C. B, ROY, V, KYLE, R. A, RAJKUMAR, S. V, FONSECA, R, GREIPP, P. R, DISPENZIERI, A, GERTZ, M. A, HAYMAN, S. R, KUMAR, S, LACY, M. Q, LUST, J. A, RUSSELL, S. J

“…Clinical outcomes for multiple myeloma (MM) are highly heterogeneous and it is now clear that pivotal genetic events are the primary harbingers of such…”
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Carfilzomib and the cardiorenal system in myeloma: an endothelial effect? by Rosenthal, A, Luthi, J, Belohlavek, M, Kortüm, K M, Mookadam, F, Mayo, A, Fonseca, R, Bergsagel, P L, Reeder, C B, Mikhael, J R, Stewart, A K

“…Carfilzomib (Cfz) has been associated with an ~5% incidence of unexplained and unpredictable cardiovascular toxicity in clinical trials. We therefore…”
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The Stickland Reaction Precursor trans -4-Hydroxy-l-Proline Differentially Impacts the Metabolism of Clostridioides difficile and Commensal Clostridia by Reed, A D, Fletcher, J R, Huang, Y Y, Thanissery, R, Rivera, A J, Parsons, R J, Stewart, A K, Kountz, D J, Shen, A, Balskus, E P, Theriot, C M

“…An intact gut microbiota confers colonization resistance against Clostridioides difficile through a variety of mechanisms, likely including competition for…”
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Compromised stem cell mobilization following induction therapy with lenalidomide in myeloma by Paripati, H, Stewart, A K, Cabou, S, Dueck, A, Zepeda, V J, Pirooz, N, Ehlenbeck, C, Reeder, C, Slack, J, Leis, J F, Boesiger, J, Torloni, A S, Fonseca, R, Bergsagel, P L

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Pomalidomide–dexamethasone in refractory multiple myeloma: long-term follow-up of a multi-cohort phase II clinical trial by Ailawadhi, S, Mikhael, J R, LaPlant, B R, Laumann, K M, Kumar, S, Roy, V, Dingli, D, Bergsagel, P L, Buadi, F K, Rajkumar, S V, Fonseca, R, Gertz, M A, Kapoor, P, Sher, T, Hayman, S R, Stewart, A K, Dispenzieri, A, Kyle, R A, Gonsalves, W I, Reeder, C B, Lin, Y, Go, R S, Leung, N, Kourelis, T, Lust, J A, Russell, S J, Chanan-Khan, A A, Lacy, M Q

“…Despite therapeutic advances, multiple myeloma remains incurable, with limited options for patients with refractory disease. We conducted a large, multi-cohort…”
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Can alternative mating tactics facilitate introgression across a hybrid zone by circumventing female choice? by Stewart, K. A., Hudson, C. M., Lougheed, S. C.

“…Reproductive barriers and divergence in species’ mate recognition systems underlie major models of speciation. However, hybridization between divergent species…”
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Stress, song and survival in sparrows by MacDougall-Shackleton, S. A., Dindia, L., Newman, A. E. M., Potvin, D. A., Stewart, K. A., MacDougall-Shackleton, E. A.

“…The stress response—increases in circulating glucocorticoids following a stressor—is typically considered adaptive, but few studies address the fitness…”
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A Primitive Growth Factor, NME7AB, Is Sufficient to Induce Stable Naïve State Human Pluripotency; Reprogramming in This Novel Growth Factor Confers Superior Differentiation by Carter, M.G., Smagghe, B.J., Stewart, A.K., Rapley, J.A., Lynch, E., Bernier, K.J., Keating, K.W., Hatziioannou, V.M., Hartman, E.J., Bamdad, Cynthia C.

“…Scientists have generated human stem cells that in some respects mimic mouse naïve cells, but their dependence on the addition of several extrinsic agents, and…”
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Longitudinal analysis of 25 sequential sample-pairs using a custom multiple myeloma mutation sequencing panel (M3P) by Kortüm, K. M., Langer, C., Monge, J., Bruins, L., Zhu, Y. X., Shi, C. X., Jedlowski, P., Egan, J. B., Ojha, J., Bullinger, L., Kull, M., Ahmann, G., Rasche, L., Knop, S, Fonseca, R., Einsele, H., Stewart, A. K., Braggio, Esteban

“…Recent advances in genomic sequencing technologies now allow results from deep next-generation sequencing to be obtained within clinically meaningful…”
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