Search Results - "Steward Jr, Robert"
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Unjamming and cell shape in the asthmatic airway epithelium
Published in Nature materials (01-10-2015)“…From coffee beans flowing in a chute to cells remodelling in a living tissue, a wide variety of close-packed collective systems—both inert and living—have the…”
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Bio-Inspired Microdevices that Mimic the Human Vasculature
Published in Micromachines (Basel) (07-10-2017)“…Blood vessels may be found throughout the entire body and their importance to human life is undeniable. This is evident in the fact that a malfunctioning blood…”
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Defining the role of syndecan-4 in mechanotransduction using surface-modification approaches
Published in Proceedings of the National Academy of Sciences - PNAS (29-12-2009)“…The ability of cells to respond to external mechanical stimulation is a complex and robust process involving a diversity of molecular interactions. Although…”
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Probing localized neural mechanotransduction through surface-modified elastomeric matrices and electrophysiology
Published in Nature protocols (01-04-2010)“…Mechanotransduction of sensory neurons is of great interest to the scientific community, especially in areas such as pain, neurobiology, cardiovascular…”
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Stiffness Decouples Cellular Mechanosensation
Published in Biophysical journal (21-07-2020)Get full text
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Illuminating human health through cell mechanics
Published in Swiss medical weekly (14-03-2013)“…Cells reside in mechanically rich and dynamic microenvironments, and the complex interplay between mechanics and biology is widely acknowledged. Recent…”
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Extracellular matrix composition alters endothelial force transmission
Published in American Journal of Physiology: Cell Physiology (01-07-2023)“…Extracellular matrix (ECM) composition is important in a host of pathophysiological processes such as angiogenesis, atherosclerosis, and diabetes, and during…”
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Fluid shear, intercellular stress, and endothelial cell alignment
Published in American Journal of Physiology: Cell Physiology (15-04-2015)“…Endothelial cell alignment along the direction of laminar fluid flow is widely understood to be a defining morphological feature of vascular homeostasis. While…”
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Open-source, 3D-printed Peristaltic Pumps for Small Volume Point-of-Care Liquid Handling
Published in Scientific reports (31-01-2020)“…Microfluidic technologies are frequently employed as point-of-care diagnostic tools for improving time-to-diagnosis and improving patient outcomes in clinical…”
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Lab-on-a-Chip for Cardiovascular Physiology and Pathology
Published in Micromachines (Basel) (28-09-2020)“…Lab-on-a-chip technologies have allowed researchers to acquire a flexible, yet relatively inexpensive testbed to study one of the leading causes of death…”
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Variable fluid flow regimes alter human brain microvascular endothelial cell–cell junctions and cytoskeletal structure
Published in Cytoskeleton (Hoboken, N.J.) (01-06-2021)“…The human brain microvasculature is constantly exposed to variable fluid flow regimes and their influence on the endothelium depends in part on the synchronous…”
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2D and 3D Mechanobiology in Human and Nonhuman Systems
Published in ACS applied materials & interfaces (31-08-2016)“…Mechanobiology involves the investigation of mechanical forces and their effect on the development, physiology, and pathology of biological systems. The human…”
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Cellular force signal integration through vector logic gates
Published in Journal of biomechanics (26-02-2015)“…Abstract The multi-signal mechanical environment mammalian cells experience is often unaccounted for in current mechanical stimulation studies. To address this…”
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Probing cell structure by controlling the mechanical environment with cell–substrate interactions
Published in Journal of biomechanics (19-01-2009)“…Abstract Recent results demonstrate the exquisite sensitivity of cell morphology and structure to mechanical stimulation. Mechanical stimulation is often…”
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Mechanical stretch and shear flow induced reorganization and recruitment of fibronectin in fibroblasts
Published in Scientific reports (08-11-2011)“…It was our objective to study the role of mechanical stimulation on fibronectin (FN) reorganization and recruitment by exposing fibroblasts to shear fluid flow…”
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Probing Cell Structure Responses Through a Shear and Stretching Mechanical Stimulation Technique
Published in Cell biochemistry and biophysics (01-04-2010)“…Cells are complex, dynamic systems that respond to various in vivo stimuli including chemical, mechanical, and scaffolding alterations. The influence of…”
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Probing Cellular Behavior Response Through Dual Mechanical Stimulation
Published 01-01-2011“…Cells have the astounding ability to sense and respond to numerous external mechanical stimuli. This stimuli which may be in the form of tension, compression,…”
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Dissertation -
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Probing Cellular Behavior Response Through Dual Mechanical Stimulation
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Dissertation