Search Results - "Steward, W"

Cancer chemoprevention: a rapidly evolving field by Steward, W P, Brown, K

“…Cancer chemoprevention involves the chronic administration of a synthetic, natural or biological agent to reduce or delay the occurrence of malignancy. The…”
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Curcumin: The story so far by Sharma, R.A., Gescher, A.J., Steward, W.P.

“…Curcumin is a polyphenol derived from the herbal remedy and dietary spice turmeric. It possesses diverse anti-inflammatory and anti-cancer properties following…”
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Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours (NETs) by Ramage, John K, Ahmed, A, Ardill, J, Bax, N, Breen, D J, Caplin, M E, Corrie, P, Davar, J, Davies, A H, Lewington, V, Meyer, T, Newell-Price, J, Poston, G, Reed, N, Rockall, A, Steward, W, Thakker, R V, Toubanakis, C, Valle, J, Verbeke, C, Grossman, A B

“…These guidelines update previous guidance published in 2005. They have been revised by a group who are members of the UK and Ireland Neuroendocrine Tumour…”
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Doxorubicin-based adjuvant chemotherapy in soft tissue sarcoma: pooled analysis of two STBSG-EORTC phase III clinical trials by Le Cesne, A., Ouali, M., Leahy, M.G., Santoro, A., Hoekstra, H.J., Hohenberger, P., Van Coevorden, F., Rutkowski, P., Van Hoesel, R., Verweij, J., Bonvalot, S., Steward, W.P., Gronchi, A., Hogendoorn, P.C.W., Litiere, S., Marreaud, S., Blay, J.Y., Van Der Graaf, W.T.A.

“…The EORTC-STBSG coordinated two large trials of adjuvant chemotherapy (CT) in localized high-grade soft tissue sarcoma (STS). Both studies failed to…”
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Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration by GARCEA, G, JONES, D. J. L, SINGH, R, DENNISON, A. R, FARMER, P. B, SHARMA, R. A, STEWARD, W. P, GESCHER, A. J, BERRY, D. P

“…Studies in vitro and in animal models of colorectal and hepatocellular cancers suggest that curcumin is an effective chemopreventive agent. In this pilot…”
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Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases--safety, pharmacokinetics, and pharmacodynamics by Howells, Lynne M, Berry, D P, Elliott, P J, Jacobson, E W, Hoffmann, E, Hegarty, B, Brown, K, Steward, W P, Gescher, A J

“…The phytochemical resveratrol has undergone extensive preclinical investigation for its putative cancer chemopreventive properties. Low systemic availability…”
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Molecular prognostic markers in pancreatic cancer: A systematic review by Garcea, G., Neal, C.P., Pattenden, C.J., Steward, W.P., Berry, D.P.

“…Pancreatic cancer is one of the most lethal tumours of the gastrointestinal tract. The ability to predict which patients would benefit most from surgical…”
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Pharmacokinetics in mice and growth-inhibitory properties of the putative cancer chemopreventive agent resveratrol and the synthetic analogue trans 3,4,5,4'-tetramethoxystilbene by SALE, S, VERSCHOYLE, R. D, BOOCOCK, D, JONES, D. J. L, WILSHER, N, RUPARELIA, K. C, POTTER, G. A, FARMER, P. B, STEWARD, W. P, GESCHER, A. J

“…Resveratrol (trans-3,5,4'-trihydroxystilbene) is a naturally occurring polyphenol with cancer chemopreventive properties in preclinical models of…”
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Vascular endothelial growth factor, platelet-derived endothelial cell growth factor and angiogenesis in non-small-cell lung cancer by O'BYRNE, K. J, KOUKOURAKIS, M. I, GIATROMANOLAKI, A, COX, G, TURLEY, H, STEWARD, W. P, GATTER, K, HARRIS, A. L

“…High microvessel density, an indirect measure of angiogenesis, has been shown to correlate with increased tumour size, lymph node involvement and poor…”
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Emotional States and Physical Health by Salovey, Peter, Detweiler, Jerusha B, Steward, Wayne T, Rothman, Alexander J

“…Positive emotional states may promote healthy perceptions, beliefs, and physical well-being itself. To explore potential mechanisms linking pleasant feelings…”
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Evaluation of the cancer chemopreventive efficacy of rice bran in genetic mouse models of breast, prostate and intestinal carcinogenesis by VERSCHOYLE, R. D, GREAVES, P, CAI, H, EDWARDS, R. E, STEWARD, W. P, GESCHER, A. J

“…Brown rice is a staple dietary constituent in Asia, whereas rice consumed in the Western world is generally white, obtained from brown rice by removal of the…”
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A phase II study of the vitamin D analogue Seocalcitol in patients with inoperable hepatocellular carcinoma by DALHOFF, K, DANCEY, J, SKOV, T, BURCHARTH, F, EVANS, T. R. J, ASTRUP, L, SKOVSGAARD, T, HAMBERG, K. J, LOFTS, F. J, ROSMORDUC, O, ERLINGER, S, BACH HANSEN, J, STEWARD, W. P

“…Hepatocellular carcinoma (HCC) is a common malignant tumour, which has a poor prognosis. Surgical resection can be curative but most patients are inoperable…”
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Primary retroperitoneal mucinous cystadenocarcinoma (PRMCa): a systematic review of the literature and meta-analysis by Myriokefalitaki, E., Luqman, I., Potdar, N., Brown, L., Steward, W., Moss, E. L.

“…Purpose Primary retroperitoneal mucinous cystadenocarcinoma (PRMCa) is a rare tumour. Prognosis and optimal management are not well established. In view of a…”
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Oxidative stress and cyclooxygenase activity in prostate carcinogenesis: targets for chemopreventive strategies by Pathak, S.K., Sharma, R.A., Steward, W.P., Mellon, J.K., Griffiths, T.R.L., Gescher, A.J.

“…Over the last decade, epidemiological, experimental and clinical studies have implicated oxidative stress in the development and progression of prostate…”
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Cellular and plasma uptake of parenteral omega-3 rich lipid emulsion fatty acids in patients with advanced pancreatic cancer by Arshad, A, Chung, W.Y, Isherwood, J, Mann, C.D, Al-Leswas, D, Steward, W.P, Metcalfe, M.S, Dennison, A.R

“…Summary Background & aims Omega-3 rich fatty acids (n-3FA) have powerful anti-inflammatory and anti-neoplastic properties. Previous studies have investigated…”
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Growth-inhibitory and cell cycle-arresting properties of the rice bran constituent tricin in human-derived breast cancer cells in vitro and in nude mice in vivo by CAI, H, HUDSON, E. A, MANN, P, VERSCHOYLE, R. D, GREAVES, P, MANSON, M. M, STEWARD, W. P, GESCHER, A. J

“…Tricin, a flavone found in rice bran, inhibits the growth of human-derived malignant MDA-MB-468 breast tumour cells at submicromolar concentrations. As part of…”
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Evaluation of the prognostic value of systemic inflammation and socioeconomic deprivation in patients with resectable colorectal liver metastases by Neal, C.P, Mann, C.D, Sutton, C.D, Garcea, G, Ong, S.L, Steward, W.P, Dennison, A.R, Berry, D.P

“…Abstract Background There is increasing evidence that the presence of a pre-operative systemic inflammatory response (SIR) independently predicts poor…”
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Soluble markers for the assessment of biological activity with PTK787/ZK 222584 (PTK/ZK), a vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor in patients with advanced colorectal cancer from two phase I trials by Drevs, J., Zirrgiebel, U., Schmidt-Gersbach, C. I. M., Mross, K., Medinger, M., Lee, L., Pinheiro, J., Wood, J., Thomas, A. L., Unger, C., Henry, A., Steward, W. P., Laurent, D., Lebwohl, D., Dugan, M., Marmé, D.

“…Background: Plasma and serum biomarkers of angiogenesis and activated endothelial cells were evaluated to assess biological activity of PTK787/ZK 222584…”
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The impact of colorectal cancer and self-efficacy beliefs on work ability and employment status: a longitudinal study by BAINS, M., MUNIR, F., YARKER, J., BOWLEY, D., THOMAS, A., ARMITAGE, N., STEWARD, W.

“…BAINS M., MUNIR F., YARKER J., BOWLEY D., THOMAS A., ARMITAGE N. & STEWARD W. (2012) European Journal of Cancer Care21, 634–641 The impact of colorectal cancer…”
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Changing trends in the presentation of colorectal liver metastases in a single hepatobiliary tertiary referral centre over fourteen years by Thomasset, S, Dennison, A, Metcalfe, M, Steward, W, Garcea, G

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