Search Results - "Stevenson, D. E."

Polyphenolic phytochemicals - just antioxidants or much more by Stevenson, D. E, Hurst, R. D

“…Polyphenolic phytochemicals are ubiquitous in plants, in which they function in various protective roles. A 'recommended' human diet contains significant…”
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DNA-based identification of Alaska skates (Amblyraja, Bathyraja and Raja: Rajidae) using cytochrome c oxidase subunit I (coI) variation by Spies, I. B., Gaichas, S., Stevenson, D. E., Orr, J. W., Canino, M. F.

“…Variation at the mitochondrial cytochrome c oxidase subunit I (mt‐COI) gene was examined in 15 species of North Pacific skates. Thirteen species had unique…”
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The Role of Oxidative Stress in Chemical Carcinogenesis by Klaunig, James E., Xu, Yong, Isenberg, Jason S., Bachowski, Stephen, Kolaja, Kyle L., Jiang, Jiazhong, Stevenson, Donald E., Walborg, Earl F.

“…Oxidative stress results when the balance between the production of reactive oxygen species (ROS) overrides the antioxidant capability of the target cell;…”
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Role of Oxidative Stress in the Selective Toxicity of Dieldrin in the Mouse Liver by Bachowski, Stephen, Xu, Yong, Stevenson, Donald E., Walborg, Earl F., Klaunig, James E.

“…Dieldrin, an organochlorine insecticide, induces hepatic tumors in mice but not in rats. Although the mechanism(s) responsible for this species specificity is…”
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Introducing Computational Science Methods Using Parallax by Stevenson, D. E.

“…We briefly describe the Clemson computational science and engineering course. We describe a parallax case study for studying floating-point computation. We…”
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Mechanistic and structural studies on Rhodococcus ATCC 39484 nitrilase by Stevenson, D E, Feng, R, Dumas, F, Groleau, D, Mihoc, A, Storer, A C

“…Rhodococcus ATCC 39484 produced a nitrilase when induced with isovaleronitrile. The enzyme was obtainable pure in milligram amounts, had a subunit Mr of 40…”
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Oxidative stress in nongenotoxic carcinogenesis by Klaunig, J.E., Xu, Y., Bachowski, S., Ketcham, C.A., Isenberg, J.S., Kolaja, K.L., Baker, T.K., Walborg, E.F., Stevenson, D.E.

“…The induction of oxidative stress in the target tissue has been proposed as a possible mechanism of action for nongenotoxic carcinogens. A variety of…”
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The Michelson-Morley experiment: a case study on validation by Stevenson, D.E.

“…The Michelson-Morley experiment can be examined, using standard mathematical concepts of error analysis, as a case study in validation. A few philosophical…”
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Monograph: Reassessment of human cancer risk of aldrin/dieldrin by Stevenson, Donald E, Walborg, Earl F, Warner North, D, Sielken, Robert L, Ross, C.E, Wright, Alan S, Xu, Yong, Kamendulis, Lisa M, Klaunig, James E

“…In 1987, the US Environmental Protection Agency (EPA) classified aldrin and dieldrin as category B 2 carcinogens, i.e. probable human carcinogens, based…”
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Are calories responsible for a decline in longevity? by Stevenson, D E, Sielken, Jr, R L

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A critical look at quality in large-scale simulations by Stevenson, D.E.

“…There is a disconnect between ASCI science and management. The author proposes an alternative paradigm. Simulation quality depends on the quality of insights…”
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Role of oxidative stress in the mechanism of dieldrin's hepatotoxicity by Bachowski, S, Kolaja, K L, Xu, Y, Ketcham, C A, Stevenson, D E, Walborg, Jr, E F, Klaunig, J E

“…The production of reactive oxygen species (ROS) by toxic chemicals has been implicated in acute and chronic disease states, including cancer. This increase in…”
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Selective dieldrin promotion of hepatic focal lesions in mice by Kolaja, Kyte L., Stevenson, Donald E., walborg, Earl F., Klaunig, James E.

“…Chronic exposure to a number of chlorinated pesticides, including dieldrin, results in an increased and/or multiplicityof hepatocellular neoplasia in mice,…”
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Reversibility of promoter induced hepatic focal lesion growth in mice by KOLAJA, K. L, STEVENSON, D. E, WALBORG, E. F, KLAUNIG, J. E

“…The effect of cessation of phenobarbital and dieldren treatment on hepatic focal lesion growth in male B6C3F1 mice was investigated. Following induction of…”
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Effect of dietary antioxidants on dieldrin-induced hepatotoxicity in mice by Stevenson, Donald E., Kehrer, James P., Kolaja, Kyle L., Walborg, Earl F., Klaunig, James E.

“…An increasing number of reports suggest that oxidative stress plays a role in the toxicity of various xenobiotics, including organochlorine pesticides and…”
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Detection of covalent enzyme-substrate complexes of nitrilase by ion-spray mass spectroscopy by Stevenson, David E., Feng, Rong, Storer, Andrew C.

“…Nitrilase from Rhodococcus ATCC 39484 was found to consist of two species of M r 40 258 ±2 and 40 388 ±2 Da. When the enzyme was incubated with nitrile…”
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Challenges to Default Assumptions Stimulate Comprehensive Realism as a New Tier in Quantitative Cancer Risk Assessment by Sielken, R.L., Bretzlaff, R.S., Stevenson, D.E.

“…The current practice in carcinogen risk assessment of using a linearized multistage model and assuming low-dose linearity is based on several false premises…”
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VITAMIN E MODULATION OF DIELDRIN-INDUCED HEPATIC FOCAL LESION GROWTH IN MICE by Kolaja, K L, Xu, Y, Walborg, Jr, E F, Stevenson, D E, Klaunig, J E

“…The effect of vitamin E on dieldrin-induced hepatic focal lesion growth in male B6C3F1 mice previously treated with diethylnitrosamine (DEN) was investigated…”
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Fern L-methionine decarboxylase: kinetics and mechanism of decarboxylation and abortive transamination by Akhtar, Mahmoud, Stevenson, David E, Gani, David

“…L-Methionine decarboxylase from Dryopteris filix-mas catalyzes the decarboxylation of L-methionine and a range of straight- and branched-chain L-amino acids to…”
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L-Methionine decarboxylase from Dryopteris filix-mas: purification, characterization, substrate specificity, abortive transamination of the coenzyme, and stereochemical courses of substrate decarboxylation and coenzyme transamination by Stevenson, David E, Akhtar, Mahmoud, Gani, David

“…L-Methionine decarboxylase from the male fern Dryopteris filix-mas has been purified 256-fold from acetone powder extracts to very near homogeneity. The enzyme…”
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