Multicentric plasma cell variant Castleman's disease presenting with cutaneous vasculitis and pulmonary parenchymal involvement in a patient with ankylosing spondylitis: case report and review of the literature

We present a case of the multicentric plasma cell variant of Castleman's disease (CD) with two rare manifestations. The patient consulted us because of cutaneous vasculitis of the lower limbs, while constitutional symptoms were nearly absent. Imaging studies also revealed pulmonary parenchymal...

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Bibliographic Details
Published in:	Acta clinica belgica (English ed. Online) Vol. 66; no. 4; pp. 305 - 310
Main Authors:	Wolf, M, Van Offel, J F, Van de Velde, A, Stevens, W J M K, De Clerck, L S
Format:	Journal Article
Language:	English
Published:	England Acta Clinica Belgica 01-07-2011 Taylor & Francis Ltd
Subjects:	Abdomen Aged Angina pectoris Ankylosing spondylitis Autoimmune diseases Calcinosis - epidemiology Cardiovascular disease Castleman Disease - diagnosis Castleman Disease - epidemiology Castleman Disease - pathology Castleman Disease - physiopathology Castleman Disease - therapy Family medical history Health aspects HIV Human immunodeficiency virus Humans Lupus Male Medical imaging Medical research Medicine, Experimental Omentum - diagnostic imaging Omentum - pathology Pathogenesis Pleura - pathology Prognosis Rheumatoid arthritis Spondylitis, Ankylosing - epidemiology Tomography Tomography, X-Ray Computed Vasculitis Vasculitis, Leukocytoclastic, Cutaneous - epidemiology
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Summary:	We present a case of the multicentric plasma cell variant of Castleman's disease (CD) with two rare manifestations. The patient consulted us because of cutaneous vasculitis of the lower limbs, while constitutional symptoms were nearly absent. Imaging studies also revealed pulmonary parenchymal involvement. Furthermore, our patient is the first case in whom association of ankylosing spondylitis with CD is reported. In addition, we present a review of the literature with emphasis on the clinical presentation of CD and its difficult discrimination from autoimmune and infectious disorders. An overview of the therapeutic options is also provided.
Bibliography:	ObjectType-Case Study-3 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Review-1 ObjectType-Feature-5 ObjectType-Report-2 ObjectType-Article-4
ISSN:	1784-3286 2295-3337
DOI:	10.2143/ACB.66A.2062574