Search Results - "Stevens, Sarah K."

The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir by Jochmans, Dirk, Liu, Cheng, Donckers, Kim, Stoycheva, Antitsa, Boland, Sandro, Stevens, Sarah K, De Vita, Chloe, Vanmechelen, Bert, Maes, Piet, Trüeb, Bettina, Ebert, Nadine, Thiel, Volker, De Jonghe, Steven, Vangeel, Laura, Bardiot, Dorothée, Jekle, Andreas, Blatt, Lawrence M, Beigelman, Leonid, Symons, Julian A, Raboisson, Pierre, Chaltin, Patrick, Marchand, Arnaud, Neyts, Johan, Deval, Jerome, Vandyck, Koen

“…The SARS-CoV-2 main protease (3CLpro) has an indispensable role in the viral life cycle and is a therapeutic target for the treatment of COVID-19. The…”
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Discovery of 4′-Chloromethyl-2′-deoxy-3′,5′-di‑O‑isobutyryl-2′-fluorocytidine (ALS-8176), A First-in-Class RSV Polymerase Inhibitor for Treatment of Human Respiratory Syncytial Virus Infection by Wang, Guangyi, Deval, Jerome, Hong, Jin, Dyatkina, Natalia, Prhavc, Marija, Taylor, Joshua, Fung, Amy, Jin, Zhinan, Stevens, Sarah K, Serebryany, Vladimir, Liu, Jyanwei, Zhang, Qingling, Tam, Yuen, Chanda, Sushmita M, Smith, David B, Symons, Julian A, Blatt, Lawrence M, Beigelman, Leo

“…Respiratory syncytial virus (RSV) is a leading pathogen of childhood and is associated with significant morbidity and mortality. To date, ribavirin is the only…”
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Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH) by Luong, Xuan G, Stevens, Sarah K, Jekle, Andreas, Lin, Tse-I, Gupta, Kusum, Misner, Dinah, Chanda, Sushmita, Mukherjee, Sucheta, Williams, Caroline, Stoycheva, Antitsa, Blatt, Lawrence M, Beigelman, Leonid N, Symons, Julian A, Raboisson, Pierre, McGowan, David, Vandyck, Koen, Deval, Jerome

“…Thyroid hormones are important modulators of metabolic activity in mammals and alter cholesterol and fatty acid levels through activation of the nuclear…”
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Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy Models by Jekle, Andreas, Thatikonda, Santosh Kumar, Jaisinghani, Ruchika, Ren, Suping, Kinkade, April, Stevens, Sarah K, Stoycheva, Antitsa, Rajwanshi, Vivek K, Williams, Caroline, Deval, Jerome, Mukherjee, Sucheta, Zhang, Qingling, Chanda, Sushmita, Smith, David B, Blatt, Lawrence M, Symons, Julian A, Gonzalvez, Francois, Beigelman, Leonid

“…Stimulator of interferon genes (STING) agonists have shown potent anti-tumor efficacy in various mouse tumor models and have the potential to overcome…”
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Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate by Deval, Jerome, Hong, Jin, Wang, Guangyi, Taylor, Josh, Smith, Lucas K, Fung, Amy, Stevens, Sarah K, Liu, Hong, Jin, Zhinan, Dyatkina, Natalia, Prhavc, Marija, Stoycheva, Antitsa D, Serebryany, Vladimir, Liu, Jyanwei, Smith, David B, Tam, Yuen, Zhang, Qingling, Moore, Martin L, Fearns, Rachel, Chanda, Sushmita M, Blatt, Lawrence M, Symons, Julian A, Beigelman, Leo

“…Respiratory syncytial virus (RSV) causes severe lower respiratory tract infections, yet no vaccines or effective therapeutics are available. ALS-8176 is a…”
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Biochemical Effect of Resistance Mutations against Synergistic Inhibitors of RSV RNA Polymerase by Deval, Jerome, Fung, Amy, Stevens, Sarah K, Jordan, Paul C, Gromova, Tatiana, Taylor, Joshua S, Hong, Jin, Meng, Jia, Wang, Guangyi, Dyatkina, Natalia, Prhavc, Marija, Symons, Julian A, Beigelman, Leo

“…ALS-8112 is the parent molecule of ALS-8176, a first-in-class nucleoside analog prodrug effective in the clinic against respiratory syncytial virus (RSV)…”
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Preclinical Characteristics of the Hepatitis C Virus NS3/4A Protease Inhibitor ITMN-191 (R7227) by Seiwert, Scott D, Andrews, Steven W, Jiang, Yutong, Serebryany, Vladimir, Tan, Hua, Kossen, Karl, Rajagopalan, P T Ravi, Misialek, Shawn, Stevens, Sarah K, Stoycheva, Antitsa, Hong, Jin, Lim, Sharlene R, Qin, Xiaoli, Rieger, Robert, Condroski, Kevin R, Zhang, Hailong, Do, Mary Geck, Lemieux, Christine, Hingorani, Gary P, Hartley, Dylan P, Josey, John A, Pan, Lin, Beigelman, Leonid, Blatt, Lawrence M

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Inhibition and Binding Kinetics of the Hepatitis C Virus NS3 Protease Inhibitor ITMN-191 Reveals Tight Binding and Slow Dissociative Behavior by Rajagopalan, Ravi, Misialek, Shawn, Stevens, Sarah K, Myszka, David G, Brandhuber, Barbara J, Ballard, Joshua A, Andrews, Steven W, Seiwert, Scott D, Kossen, Karl

“…The protease activity of hepatitis C virus nonstructural protein 3 (NS3) is essential for viral replication. ITMN-191, a macrocyclic inhibitor of the NS3…”
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Nucleosides for the treatment of respiratory RNA virus infections by Jordan, Paul C, Stevens, Sarah K, Deval, Jerome

“…Influenza virus, respiratory syncytial virus, human metapneumovirus, parainfluenza virus, coronaviruses, and rhinoviruses are among the most common viruses…”
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Differential Associations of Childhood Abuse and Neglect with Adult Autonomic Regulation and Mood-Related Pathology by Stevens, Sarah K., Williams, DeWayne P., Thayer, Julian F., Zalta, Alyson K.

“…This study assessed whether different types of childhood maltreatment (i.e., abuse vs. neglect) had differential relationships with heart rate variability…”
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The influence of neuropeptide Y (NPY) on the relationship between emotion regulation and mood-related pathology in survivors of childhood interpersonal trauma by Stevens, Sarah K., Boley, Randy, Pollack, Mark, Hobfoll, Stevan, Shankman, Stewart, Pinkerton, Linzy, Valdespino-Hayden, Zerbrina, Glover, Angela C., Kaufman, Michelle, Dowd, Sheila, Zalta, Alyson K.

“…Neuropeptide Y (NPY) is a 36-amino acid peptide that is widely expressed throughout the limbic system. Recent evidence has highlighted NPY as a marker of…”
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Brain derived neurotrophic factor and treatment outcomes among veterans attending an intensive treatment program for posttraumatic stress disorder by Zalta, Alyson K., Voigt, Robin M., Stevens, Sarah K., Held, Philip, Raeisi, Shohreh, Boley, Randy A., Keshavarzian, Ali, Pollack, Mark H.

“…Brain derived neurotrophic factor (BDNF) may play an important role in the success of treatment for posttraumatic stress disorder (PTSD). Pre- and…”
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Scoring the Life Events Checklist: Comparison of Three Scoring Methods by Weis, Carissa N., Webb, E. Kate, Stevens, Sarah K., Larson, Christine L., deRoon-Cassini, Terri A.

“…Objective: Prior trauma history is a reliable and robust risk predictor for PTSD development. Obtaining an accurate measurement of prior trauma history is…”
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Discovery and Preclinical Profile of ALG-055009, a Potent and Selective Thyroid Hormone Receptor Beta (THR-β) Agonist for the Treatment of MASH by Vandyck, Koen, McGowan, David C, Luong, Xuan G, Stevens, Sarah K, Jekle, Andreas, Gupta, Kusum, Misner, Dinah L, Chanda, Sushmita, Serebryany, Vladimir, Welch, Michael, Hu, Haiyang, Lv, Zhidan, Williams, Caroline, Maskos, Klaus, Lammens, Alfred, Stoycheva, Antitsa D, Lin, Tse-I, Blatt, Lawrence M, Beigelman, Leonid N, Symons, Julian A, Raboisson, Pierre, Deval, Jerome

“…Agonists of thyroid hormone receptor β (THR-β) decreased LDL cholesterol (LDL-C) and triglyceride (TG) levels in human clinical trials for patients with…”
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Event centrality and posttraumatic stress symptoms after traumatic injury: A longitudinal investigation by Stevens, Sarah K., Timmer‐Murillo, Sydney C., Tomas, Carissa W., Boals, Adriel, Larson, Christine L., deRoon‐Cassini, Terri, Larsen, Sadie E.

“…The development of posttraumatic stress symptoms (PTSS) can occur following a traumatic injury, which may include an increase in negative cognitions. One…”
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Activation Pathway of a Nucleoside Analog Inhibiting Respiratory Syncytial Virus Polymerase by Jordan, Paul C, Stevens, Sarah K, Tam, Yuen, Pemberton, Ryan P, Chaudhuri, Shuvam, Stoycheva, Antitsa D, Dyatkina, Natalia, Wang, Guangyi, Symons, Julian A, Deval, Jerome, Beigelman, Leo

“…Human respiratory syncytial virus (RSV) is a negative-sense RNA virus and a significant cause of respiratory infection in infants and the elderly. No effective…”
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Solid-phase synthesis of 5′-triphosphate 2′-5′-oligoadenylates analogs with 3′-O-biolabile groups and their evaluation as RNase L activators and antiviral drugs by Thillier, Yann, Stevens, Sarah K., Moy, Christabel, Taylor, Joshua, Vasseur, Jean-Jacques, Beigelman, Leonid, Debart, Françoise

“…5′-Triphosphate 2′-5′-oligoadenylate (2–5A) is the central player in the 2–5A system that is an innate immunity pathway in response to the presence of…”
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Optimization of the multiple enzymatic activities of the hepatitis C virus NS3 protein by Misialek, Shawn, Rajagopalan, Ravi, Stevens, Sarah K., Beigelman, Leonid, Seiwert, Scott D., Kossen, Karl

“…The hepatitis C virus (HCV) nonstructural protein 3 (NS3) is known to possess multiple enzymatic activities. In addition to its well-characterized protease…”
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Gene Structure, Dual-promoters and mRNA Alternative Splicing of the Human and Mouse Regulator of G Protein Signaling GAIP/RGS19 by Xie, Guo-xi, Han, Xiaokang, Ito, Emi, Yanagisawa, Yuka, Maruyama, Kazuo, Sugano, Sumio, Suzuki, Yutaka, Wang, Yan, Gabriel, Anja, Stevens, Sarah K., Mitchell, James, Sharma, Manohar, Palmer, Pamela Pierce

“…Here we report the gene structure and transcription regulation of the human and mouse G protein-signaling regulator GAIP/RGS19. The GAIP/RGS19 gene is adjacent…”
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Regulation of gene transcription by thyroid hormone receptor [beta] agonists in clinical development for the treatment of non-alcoholic steatohepatitis by Luong, Xuan G, Stevens, Sarah K, Jekle, Andreas, Lin, Tse-I, Gupta, Kusum, Misner, Dinah, Chanda, Sushmita, Mukherjee, Sucheta, Williams, Caroline, Stoycheva, Antitsa, Blatt, Lawrence M, Beigelman, Leonid N, Symons, Julian A, Raboisson, Pierre, McGowan, David, Vandyck, Koen, Deval, Jerome

“…Thyroid hormones are important modulators of metabolic activity in mammals and alter cholesterol and fatty acid levels through activation of the nuclear…”
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