Search Results - "Stevens, N.E."

In-vitro and in-vivo erosion profiles of hydroxypropylmethylcellulose (HPMC) matrix tablets by Ghimire, Manish, Hodges, Lee Ann, Band, Janet, O'Mahony, Bridget, McInnes, Fiona J., Mullen, Alexander B., Stevens, Howard N.E.

“…The purpose of this study was to evaluate and compare the in-vitro and in-vivo erosion profiles of two tablet formulations primarily consisting of…”
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Evaluation of Pulsincap™ to provide regional delivery of dofetilide to the human GI tract by Stevens, Howard N.E, Wilson, Clive G, Welling, Peter G, Bakhshaee, Massoud, Binns, Julie S, Perkins, Alan C, Frier, Malcolm, Blackshaw, Elaine P, Frame, Margaret W, Nichols, Don J, Humphrey, Michael J, Wicks, Steve R

“…Pulsincap™ formulations designed to deliver a dose of drug following a 5-h delay were prepared to evaluate the capability of the formulation to deliver…”
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Depletion of high-affinity corticosteroid-binding globulin corresponds to illness severity in sepsis and septic shock; clinical implications by Nenke, M.A., Rankin, W., Chapman, M.J., Stevens, N.E., Diener, K.R., Hayball, J. D., Lewis, J.G., Torpy, D.J.

“…Summary Objective Corticosteroid‐binding globulin (CBG) is cleaved by neutrophil elastase converting the high‐affinity (haCBG) conformation of CBG to a…”
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Calcium supplementation and bone mineral density in females from childhood to young adulthood: a randomized controlled trial by Matkovic, V, Goel, P.K, Badenhop-Stevens, N.E, Landoll, J.D, Li, B, Ilich, J.Z, Skugor, M, Nagode, L.A, Mobley, S.L, Ha, E.J

“…Background: Short-term studies established that calcium influences bone accretion during growth. Whether long-term supplementation influences bone accretion in…”
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The effect of wet granulation on the erosion behaviour of an HPMC–lactose tablet, used as a rate-controlling component in a pulsatile drug delivery capsule formulation by McConville, Jason T, Ross, Alistair C, Chambers, Alan R, Smith, Geoff, Florence, Alastair J, Stevens, Howard N.E

“…The purpose of this study was to investigate the variability in the performance of a pulsatile capsule delivery system induced by wet granulation of an…”
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Nutrition influences skeletal development from childhood to adulthood: a study of hip, spine, and forearm in adolescent females by Matkovic, Velimir, Landoll, John D, Badenhop-Stevens, Nancy E, Ha, Eun-Yeong, Crncevic-Orlic, Zeljka, Li, Bin, Goel, Prem

“…This study evaluated the long-term efficacy of supplemental calcium and dairy products on bone mineral areal density of the hip and spine and on the bone…”
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Investigating the coating-dependent release mechanism of a pulsatile capsule using NMR microscopy by Sutch, Jonathan C.D, Ross, Alistair C, Köckenberger, Walter, Bowtell, Richard W, MacRae, Ross J, Stevens, Howard N.E, Melia, Colin D

“…Chronopharmaceutical capsules, ethylcellulose-coated to prevent water ingress, exhibited clearly different release characteristics when coated by organic or…”
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Wound healing dressings and drug delivery systems: a review by Boateng, Joshua S, Matthews, Kerr H, Stevens, Howard N E, Eccleston, Gillian M

“…The variety of wound types has resulted in a wide range of wound dressings with new products frequently introduced to target different aspects of the wound…”
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A New Class of Safe Oligosaccharide Polymer Therapy To Modify the Mucus Barrier of Chronic Respiratory Disease by Pritchard, Manon F, Powell, Lydia C, Menzies, Georgina E, Lewis, Paul D, Hawkins, Karl, Wright, Chris, Doull, Iolo, Walsh, Timothy R, Onsøyen, Edvar, Dessen, Arne, Myrvold, Rolf, Rye, Philip D, Myrset, Astrid H, Stevens, Howard N. E, Hodges, Lee A, MacGregor, Gordon, Neilly, James B, Hill, Katja E, Thomas, David W

“…The host- and bacteria-derived extracellular polysaccharide coating of the lung is a considerable challenge in chronic respiratory disease and is a powerful…”
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Characterisation of freeze-dried wafers and solvent evaporated films as potential drug delivery systems to mucosal surfaces by Boateng, Joshua S., Auffret, Anthony D., Matthews, Kerr H., Humphrey, Michael J., Stevens, Howard N.E., Eccleston, Gillian M.

“…Freeze-dried (lyophilised) wafers and solvent cast films from sodium alginate (ALG) and sodium carboxymethylcellulose (CMC) have been developed as potential…”
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Development and mechanical characterization of solvent-cast polymeric films as potential drug delivery systems to mucosal surfaces by Boateng, Joshua S., Stevens, Howard N.E., Eccleston, Gillian M., Auffret, Anthony D., Humphrey, Michael J., Matthews, Kerr H.

“…Solvent-cast films from three polymers, carboxymethylcellulose (CMC), sodium alginate (SA), and xanthan gum, were prepared by drying the polymeric gels in air…”
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Assessing gastrointestinal motility and disintegration profiles of magnetic tablets by a novel magnetic imaging device and gamma scintigraphy by Goodman, Kirsteen, Hodges, Lee Ann, Band, Janet, Stevens, Howard N.E., Weitschies, Werner, Wilson, Clive G.

“…To validate Magnetic Moment Imaging (MMI) for the investigation of gastrointestinal transit and disintegration of solid dosage forms and to correlate the MMI…”
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Modulation of gastric pH by a buffered soluble effervescent formulation: A possible means of improving gastric tolerability of alendronate by Hodges, L.A., Connolly, S.M., Winter, J., Schmidt, T., Stevens, H.N.E., Hayward, M., Wilson, C.G.

“…Gastrointestinal side-effects of alendronate (ALN) are believed to be associated with oesophageal lodging of tablets and perhaps reflux of gastric contents…”
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Scintigraphic evaluation of colon targeting pectin–HPMC tablets in healthy volunteers by Hodges, L.A., Connolly, S.M., Band, J., O’Mahony, B., Ugurlu, T., Turkoglu, M., Wilson, C.G., Stevens, H.N.E.

“…The in vivo evaluation of colon-targeting tablets was conducted in six healthy male volunteers. A pectin–hydroxypropyl methylcellulose coating was compressed…”
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Calcium supplementation and bone fragility fractures during growth by Matkovic, V., Landoll, J.D., Badenhop-Stevens, N.E., Ha, E.-J., Crncevic-Orlic, Z., Li, B., Goel, P.K.

“…It is known from short-term studies that calcium supplementation influences bone accretion during growth, but whether this has any implication with regard to…”
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Pharmacoscintigraphy confirms consistent tamsulosin release from a novel triple-layered tablet by Hodges, L.A., Sime, K.A., Creech, L.A., Connolly, S.M., Barclay, S.T., Kwon, Min Chang, Jeon, Byeong Jin, Shim, Sang Min, Wang, Hun Sik, Stevens, H.N.E., Park, Jun Sang

“…Conventional modified release preparations of tamsulosin HCl have been linked to increased incidence of cardiovascular adverse events, possibly due to rapid…”
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Correlation between in vitro and in vivo erosion behaviour of erodible tablets using gamma scintigraphy by Ghimire, Manish, Hodges, Lee Ann, Band, Janet, Lindsay, Blythe, O’Mahony, Bridget, McInnes, Fiona J., Mullen, Alexander B., Stevens, Howard N.E.

“…Effect of manufacturing methods on in vitro and in vivo erosion profiles of wax-disintegrant based matrix tablets using gamma scintigraphy. In vitro and in…”
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In-vitro/in-vivo correlation of pulsatile drug release from press-coated tablet formulations: A pharmacoscintigraphic study in the beagle dog by Ghimire, Manish, McInnes, Fiona J., Watson, David G., Mullen, Alexander B., Stevens, Howard N.E.

“…The aim of the current study was to investigate the in-vitro and in-vivo performance of a press-coated tablet (PCT) intended for time delayed drug release,…”
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Lyophilised wafers as a drug delivery system for wound healing containing methylcellulose as a viscosity modifier by Matthews, K.H., Stevens, H.N.E., Auffret, A.D., Humphrey, M.J., Eccleston, G.M.

“…Lyophilised wafers have potential as drug delivery systems for suppurating wounds. A dual series of wafers made from low molecular weight sodium alginate (SA)…”
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Formulation, stability and thermal analysis of lyophilised wound healing wafers containing an insoluble MMP-3 inhibitor and a non-ionic surfactant by Matthews, K.H., Stevens, H.N.E., Auffret, A.D., Humphrey, M.J., Eccleston, G.M.

“…Lyophilised wafers are being developed as topical drug delivery systems for the treatment of chronic wounds. This study describes the formulation of xanthan…”
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