Search Results - "Stevens, F. M."

Failed epidural: causes and management by Hermanides, J., Hollmann, M.W., Stevens, M.F., Lirk, P.

“…Failed epidural anaesthesia or analgesia is more frequent than generally recognized. We review the factors known to influence the success rate of epidural…”
Get full text

Apoptosis induction by different local anaesthetics in a neuroblastoma cell line by Werdehausen, R., Fazeli, S., Braun, S., Hermanns, H., Essmann, F., Hollmann, M.W., Bauer, I., Stevens, M.F.

“…Local anaesthetics are known to induce apoptosis in clinically relevant concentrations. Hitherto, it is unknown what determines the apoptotic potency of local…”
Get full text

Quantifying the reduction of respiratory motion by mechanical ventilation with MRI for radiotherapy by van Kesteren, Z, Veldman, J K, Parkes, M J, Stevens, M F, Balasupramaniam, P, van den Aardweg, J G, van Tienhoven, G, Bel, A, van Dijk, I W E M

“…Due to respiratory motion, accurate radiotherapy delivery to thoracic and abdominal tumors is challenging. We aimed to quantify the ability of mechanical…”
Get full text

PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy by Salvati, E, Scarsella, M, Porru, M, Rizzo, A, Iachettini, S, Tentori, L, Graziani, G, D'Incalci, M, Stevens, M F G, Orlandi, A, Passeri, D, Gilson, E, Zupi, G, Leonetti, C, Biroccio, A

“…New anti-telomere strategies represent important goals for the development of selective cancer therapies. In this study, we reported that uncapped telomeres,…”
Get full text

Correction: Quantifying the reduction of respiratory motion by mechanical ventilation with MRI for radiotherapy by van Kesteren, Z, Veldman, J. K, Parkes, M. J, Stevens, M. F, Balasupramaniam, P, van den Aardweg, J. G, van Tienhoven, G, Bel, A, van Dijk, I. W. E. M

Get full text

Ketamine induces apoptosis via the mitochondrial pathway in human lymphocytes and neuronal cells by Braun, S, Gaza, N, Werdehausen, R, Hermanns, H, Bauer, I, Durieux, M.E., Hollmann, M.W., Stevens, M.F.

“…Ketamine has been shown to have neurotoxic properties, when administered neuraxially. The mechanism of this local toxicity is still unknown. Therefore, we…”
Get full text

Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism by PHATAK, P, COOKSON, J. C, DAI, F, SMITH, V, GARTENHAUS, R. B, STEVENS, M. F. G, BURGER, A. M

“…The pentacyclic acridinium methosulfate salt RHPS4 induces the 3'single-stranded guanine-rich telomeric overhang to fold into a G-quadruplex structure…”
Get full text

Effects of early and late diabetic neuropathy on sciatic nerve block duration and neurotoxicity in Zucker diabetic fatty rats by Lirk, P., Verhamme, C., Boeckh, R., Stevens, M.F., ten Hoope, W., Gerner, P., Blumenthal, S., de Girolami, U., van Schaik, I.N., Hollmann, M.W., Picardi, S.

“…The neuropathy of type II diabetes mellitus (DM) is increasing in prevalence worldwide. We aimed to test the hypothesis that in a rodent model of type II DM,…”
Get full text

Sedation during spinal anaesthesia in infants by Hermanns, H., Stevens, M.F., Werdehausen, R., Braun, S., Lipfert, P., Jetzek-Zader, M.

“…Neuraxial anaesthesia in adults decreases the dose of i.v. or inhalational anaesthetic needed to reach a desired level of sedation. Furthermore, spinal…”
Get full text

Assessment of skin temperature during regional anaesthesia—What the anaesthesiologist should know by Hermanns, H., Werdehausen, R., Hollmann, M. W., Stevens, M. F.

“…Body temperature homeostasis is accurately regulated by complex feedback‐driven neuronal mechanisms, which involve a multitude of thermoregulatory pathways…”
Get full text

Comparison of percutaneous electrical nerve stimulation and ultrasound imaging for nerve localization by Wegener, J. T., Boender, Z. J., Preckel, B., Hollmann, M. W., Stevens, M. F.

“…Background Percutaneous nerve stimulation (PNS) is a non-invasive technique to localize superficial nerves before performing peripheral nerve blocks, but its…”
Get full text

Quantitative agreement between [15O]H2O PET and model free QUASAR MRI-derived cerebral blood flow and arterial blood volume by Heijtel, D.F.R., Petersen, E.T., Mutsaerts, H.J.M.M., Bakker, E., Schober, P., Stevens, M.F., van Berckel, B.N.M, Majoie, C.B.L.M., Booij, J., van Osch, M.J.P., van Bavel, E.T., Boellaard, R., Lammertsma, A.A., Nederveen, A.J.

“…The purpose of this study was to assess whether there was an agreement between quantitative cerebral blood flow (CBF) and arterial cerebral blood volume (CBVA)…”
Get full text

Cortical somatosensory-evoked potentials during spine surgery in patients with neuromuscular and idiopathic scoliosis under propofol–remifentanil anaesthesia by Hermanns, H., Lipfert, P., Meier, S., Jetzek-Zader, M., Krauspe, R., Stevens, M.F.

“…Intraoperative monitoring of the spinal cord via cortical somatosensory-evoked potentials (SSEP) is a routine during spinal surgery. However, especially in…”
Get full text

Cancer Research Campaign phase II trial of temozolomide in metastatic melanoma by Bleehen, N M, Newlands, E S, Lee, S M, Thatcher, N, Selby, P, Calvert, A H, Rustin, G J, Brampton, M, Stevens, M F

“…Sixty patients with metastatic melanoma were treated in a phase II study with the imidazotetrazine derivative temozolamide to assess further the efficacy…”
Get more information

The G-quadruplex-stabilising agent RHPS4 induces telomeric dysfunction and enhances radiosensitivity in glioblastoma cells by Berardinelli, F., Siteni, S., Tanzarella, C., Stevens, M.F., Sgura, A., Antoccia, A.

“…•RHPS4 G4-ligand induces telomere dysfunction and inhibits growth of astrocytoma cells.•Normal primary fibroblasts are resistant to the RHPS4 agent.•RHPS4…”
Get full text

DNA damage and cell cycle arrest induced by 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) is attenuated in aryl hydrocarbon receptor deficient MCF-7 cells by TRAPANI, V, PATEL, V, LEONG, C.-O, CIOLINO, H. P, YEH, G. C, HOSE, C, TREPEL, J. B, STEVENS, M. F. G, SAUSVILLE, E. A, LOAIZA-PEREZ, A. I

“…The fluorinated benzothiazole analogue 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) is a novel agent with potent and selective…”
Get full text

The effect of mirtazapine in patients with chronic pain and concomitant depression by Freynhagen, R., Muth-Selbach, U., Lipfert, P., Stevens, M. F., Zacharowski, K., Tölle, T. R., von Giesen, H.‐J.

“…ABSTRACT Objective: To evaluate the safety, tolerability and efficacy of mirtazapine in patients with the primary diagnosis of chronic pain and concomitant…”
Get full text

In vitro evaluation of amino acid prodrugs of novel antitumour 2-(4-amino-3-methylphenyl)benzothiazoles by BRADSHAW, T. D, CHUA, M.-S, BROWNE, H. L, TRAPANI, V, SAUSVILLE, E. A, STEVENS, M. F. G

“…Novel 2-(4-aminophenyl)benzothiazoles possess highly selective, potent antitumour properties in vitro and in vivo. They induce and are biotransformed by…”
Get full text

Ultrasound guided supra-inguinal Fascia Iliaca Compartment Blocks in hip fracture patients: An alternative technique by Ridderikhof, M.L., De Kruif, E., Stevens, M.F., Baumann, H.M., Lirk, P.B., Goslings, J.C., Hollmann, M.W.

“…In the Emergency Department, regional anesthesia is increasingly used in elderly patients with hip fractures. An example is a Fascia Iliaca Compartment Block…”
Get full text

Benzylidene derivatives of andrographolide inhibit growth of breast and colon cancer cells in vitro by inducing G(1) arrest and apoptosis by Jada, S R, Matthews, C, Saad, M S, Hamzah, A S, Lajis, N H, Stevens, M F G, Stanslas, J

“…Andrographolide, the major phytoconstituent of Andrographis paniculata, was previously shown by us to have activity against breast cancer. This led to…”
Get full text