Search Results - "Stevens, Edward B"

The biophysical and molecular basis of TRPV1 proton gating by Aneiros, Eduardo, Cao, Lishuang, Papakosta, Marianthi, Stevens, Edward B, Phillips, Stephen, Grimm, Christian

“…The capsaicin receptor TRPV1, a member of the transient receptor potential family of non‐selective cation channels is a polymodal nociceptor. Noxious thermal…”
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The role of sodium channels in neuropathic pain by Rogers, Marc, Tang, Lam, Madge, David J., Stevens, Edward B.

“…Our knowledge of the ion channels, receptors and signalling mechanisms involved in pain pathophysiology, and which specific channels play a role in subtypes of…”
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Spontaneous activity in peripheral sensory nerves: a systematic review by Choi, Dongchan, Goodwin, George, Stevens, Edward B, Soliman, Nadia, Namer, Barbara, Denk, Franziska

“…In the peripheral nervous system, spontaneous activity in sensory neurons is considered to be one of the 2 main drivers of chronic pain states, alongside…”
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Examination of the contribution of Nav1.7 to axonal propagation in nociceptors by Goodwin, George, McMurray, Sheridan, Stevens, Edward B., Denk, Franziska, McMahon, Stephen B.

“…Nav1.7 is a promising drug target for the treatment of pain. However, there is a mismatch between the analgesia produced by Nav1.7 loss-of-function and the…”
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Recent advances in targeting ion channels to treat chronic pain by Stevens, Edward B, Stephens, Gary J

“…Linked Articles This article is part of a themed section on Recent Advances in Targeting Ion Channels to Treat Chronic Pain. To view the other articles in this…”
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Pharmacological reversal of a pain phenotype in iPSC-derived sensory neurons and patients with inherited erythromelalgia by Cao, Lishuang, McDonnell, Aoibhinn, Nitzsche, Anja, Alexandrou, Aristos, Saintot, Pierre-Philippe, Loucif, Alexandre J C, Brown, Adam R, Young, Gareth, Mis, Malgorzata, Randall, Andrew, Waxman, Stephen G, Stanley, Philip, Kirby, Simon, Tarabar, Sanela, Gutteridge, Alex, Butt, Richard, McKernan, Ruth M, Whiting, Paul, Ali, Zahid, Bilsland, James, Stevens, Edward B

“…In common with other chronic pain conditions, there is an unmet clinical need in the treatment of inherited erythromelalgia (IEM). TheSCN9Agene encoding the…”
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Ion Channels as Therapeutic Targets: A Drug Discovery Perspective by Bagal, Sharan K, Brown, Alan D, Cox, Peter J, Omoto, Kiyoyuki, Owen, Robert M, Pryde, David C, Sidders, Benjamin, Skerratt, Sarah E, Stevens, Edward B, Storer, R. Ian, Swain, Nigel A

“…Ion channels are membrane proteins expressed in almost all living cells. The sequencing of the human genome has identified more than 400 putative ion channels,…”
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A small molecule CFTR potentiator restores ATP‐dependent channel gating to the cystic fibrosis mutant G551D‐CFTR by Liu, Jia, Berg, Allison P., Wang, Yiting, Jantarajit, Walailak, Sutcliffe, Katy J., Stevens, Edward B., Cao, Lishuang, Pregel, Marko J., Sheppard, David N.

“…Background and Purpose Cystic fibrosis transmembrane conductance regulator (CFTR) potentiators are small molecules developed to treat the genetic disease…”
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Dynamic Social Networks in Recovery Homes by Jason, Leonard A., Light, John M., Stevens, Edward B., Beers, Kimberly

“…Acute treatment aftercare in the form of sober living environments—i.e., recovery houses—provide an inexpensive and effective medium-term treatment alternative…”
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CACHD1 is an α2δ-Like Protein That Modulates CaV3 Voltage-Gated Calcium Channel Activity by Cottrell, Graeme S, Soubrane, Camille H, Hounshell, James A, Lin, Hong, Owenson, Venetia, Rigby, Michael, Cox, Peter J, Barker, Bryan S, Ottolini, Matteo, Ince, Selvi, Bauer, Claudia C, Perez-Reyes, Edward, Patel, Manoj K, Stevens, Edward B, Stephens, Gary J

“…The putative cache (Ca 2+ channel and chemotaxis receptor) domain containing 1 (CACHD1) protein has predicted structural similarities to members of the α2δ…”
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GI‐530159, a novel, selective, mechanosensitive two‐pore‐domain potassium (K2P) channel opener, reduces rat dorsal root ganglion neuron excitability by Loucif, Alexandre J C, Saintot, Pierre‐Philippe, Liu, Jia, Antonio, Brett M, Zellmer, Shannon G, Yoger, Katrina, Veale, Emma L, Wilbrey, Anna, Omoto, Kiyoyuki, Cao, Lishuang, Gutteridge, Alex, Castle, Neil A, Stevens, Edward B, Mathie, Alistair

“…Background and Purpose TREK two‐pore‐domain potassium (K2P) channels play a critical role in regulating the excitability of somatosensory nociceptive neurons…”
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Characterizing Human Stem Cell–derived Sensory Neurons at the Single-cell Level Reveals Their Ion Channel Expression and Utility in Pain Research by Young, Gareth T, Gutteridge, Alex, Fox, Heather DE, Wilbrey, Anna L, Cao, Lishuang, Cho, Lily T, Brown, Adam R, Benn, Caroline L, Kammonen, Laura R, Friedman, Julia H, Bictash, Magda, Whiting, Paul, Bilsland, James G, Stevens, Edward B

“…The generation of human sensory neurons by directed differentiation of pluripotent stem cells opens new opportunities for investigating the biology of pain…”
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Influence of the N terminus on the biophysical properties and pharmacology of TREK1 potassium channels by Veale, Emma L, Al-Moubarak, Ehab, Bajaria, Naina, Omoto, Kiyoyuki, Cao, Lishuang, Tucker, Stephen J, Stevens, Edward B, Mathie, Alistair

“…TWIK-related K(+) 1 (TREK1) potassium channels are members of the two-pore domain potassium channel family and contribute to background potassium conductances…”
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An Intracellular Allosteric Modulator Binding Pocket in SK2 Ion Channels Is Shared by Multiple Chemotypes by Cho, Lily T.-Y., Alexandrou, Aristos J., Torella, Rubben, Knafels, John, Hobbs, Jake, Taylor, Toni, Loucif, Alex, Konopacka, Agnieszka, Bell, Sigourney, Stevens, Edward B., Pandit, Jay, Horst, Reto, Withka, Jane M., Pryde, David C., Liu, Shenping, Young, Gareth T.

“…Small conductance potassium (SK) ion channels define neuronal firing rates by conducting the after-hyperpolarization current. They are key targets in…”
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A novel selective and orally bioavailable Nav1.8 channel blocker, PF‐01247324, attenuates nociception and sensory neuron excitability by Payne, Claire Elizabeth, Brown, Adam R, Theile, Jonathon W, Loucif, Alexandre J C, Alexandrou, Aristos J, Fuller, Mathew D, Mahoney, John H, Antonio, Brett M, Gerlach, Aaron C, Printzenhoff, David M, Prime, Rebecca L, Stockbridge, Gillian, Kirkup, Anthony J, Bannon, Anthony W, England, Steve, Chapman, Mark L, Bagal, Sharan, Roeloffs, Rosemarie, Anand, Uma, Anand, Praveen, Bungay, Peter J, Kemp, Mark, Butt, Richard P, Stevens, Edward B

“…Background and Purpose NaV1.8 ion channels have been highlighted as important molecular targets for the design of low MW blockers for the treatment of chronic…”
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Evaluating alcoholics anonymous sponsor attributes using conjoint analysis by Stevens, Edward B, Jason, Leonard A

“…Abstract Alcoholics Anonymous (AA) considers sponsorship an important element of the AA program, especially in early recovery. 225 adult individuals who had…”
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An Empirically Based Theory of the Relationships among Social Embeddedness, Economic Viability, Learned Recovery Skills and Perceived Quality of Life in Recovery Homes by Jason, Leonard A., Stevens, Edward B., Light, John M., Doogan, Nathan J.

“…Key characteristics of recovery homes include governance style (which can play a central role in structuring recovery mechanisms), social embeddedness (e.g.,…”
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AN INVESTIGATION OF HOPE AND CONTEXT by Stevens, Edward B., Buchannan, Brett, Ferrari, Joseph R., Jason, Leonard A., Ram, Daphna

“…One of the tenets of community psychology is examining psychological phenomena in context, and our studies explored the relationship between hope and context…”
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The discovery and optimization of benzimidazoles as selective NaV1.8 blockers for the treatment of pain by Brown, Alan D., Bagal, Sharan K., Blackwell, Paul, Blakemore, David C., Brown, Bruce, Bungay, Peter J., Corless, Martin, Crawforth, James, Fengas, David, Fenwick, David R., Gray, Victoria, Kemp, Mark, Klute, Wolfgang, Malet Sanz, Laia, Miller, Duncan, Murata, Yoshihisa, Payne, C. Elizabeth, Skerratt, Sarah, Stevens, Edward B., Warmus, Joseph S.

“…[Display omitted] The voltage gated sodium channel NaV1.8 has been postulated to play a key role in the transmission of pain signals. Core hopping from our…”
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Personality, Self-Esteem, and Perceived Stress in Communal Residences Supporting Recovery by Reilly, Angela, Stevens, Edward B, Jason, Leonard A

“…The current study examined the relationships between a personality metatrait (Stability consisting of conscientiousness, agreeableness, and neuroticism),…”
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