Search Results - "Stevens, Charles M."

Characterization of Zebrafish Cardiac and Slow Skeletal Troponin C Paralogs by MD Simulation and ITC by Stevens, Charles M., Rayani, Kaveh, Genge, Christine E., Singh, Gurpreet, Liang, Bo, Roller, Janine M., Li, Cindy, Li, Alison Yueh, Tieleman, D. Peter, van Petegem, Filip, Tibbits, Glen F.

“…Zebrafish, as a model for teleost fish, have two paralogous troponin C (TnC) genes that are expressed in the heart differentially in response to temperature…”
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Familial hypertrophic cardiomyopathy related cardiac troponin C L29Q mutation alters length-dependent activation and functional effects of phosphomimetic troponin I by Li, Alison Y, Stevens, Charles M, Liang, Bo, Rayani, Kaveh, Little, Sean, Davis, Jonathan, Tibbits, Glen F

“…The Ca(2+) binding properties of the FHC-associated cardiac troponin C (cTnC) mutation L29Q were examined in isolated cTnC, troponin complexes, reconstituted…”
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Changes in the dynamics of the cardiac troponin C molecule explain the effects of Ca2+-sensitizing mutations by Stevens, Charles M., Rayani, Kaveh, Singh, Gurpreet, Lotfalisalmasi, Bairam, Tieleman, D.Peter, Tibbits, Glen F.

“…Cardiac troponin C (cTnC) is the regulatory protein that initiates cardiac contraction in response to Ca2+. TnC binding Ca2+ initiates a cascade of…”
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In vitro analyses of suspected arrhythmogenic thin filament variants as a cause of sudden cardiac death in infants by Shafaattalab, Sanam, Li, Alison Yueh, Lin, Eric, Stevens, Charles M., Dewar, Laura J., Lynn, Francis C., Sanatani, Shubhayan, Laksman, Zachary, Morin, Ryan D., van Petegem, Filip, Hove-Madsen, Leif, Tieleman, D. Peter, Davis, Jonathan P., Tibbits, Glen F.

“…Sudden unexpected death of an infant (SUDI) is a devastating occurrence for families. To investigate the genetic pathogenesis of SUDI, we sequenced >70 genes…”
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Investigating the Genetic Causes of Sudden Unexpected Death in Children Through Targeted Next-Generation Sequencing Analysis by Dewar, Laura J, Alcaide, Miguel, Fornika, Daniel, D’Amato, Luisa, Shafaatalab, Sanam, Stevens, Charles M, Balachandra, Thambirajah, Phillips, Susan M, Sanatani, Shubhayan, Morin, Ryan D, Tibbits, Glen F

“…BACKGROUND—Inherited arrhythmia syndromes are responsible for a significant portion of autopsy-negative sudden unexpected death (SUD) cases, but molecular…”
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Purification of a Tat leader peptide by co-expression with its chaperone by Stevens, Charles M., Paetzel, Mark

“…[Display omitted] ► A method for the purification of a recombinant Tat leader peptide is presented. ► Escherichia coli DmsA leader peptide (DmsAL) is…”
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The Zebrafish Heart as a Model of Mammalian Cardiac Function by Genge, Christine E, Lin, Eric, Lee, Ling, Sheng, XiaoYe, Rayani, Kaveh, Gunawan, Marvin, Stevens, Charles M, Li, Alison Yueh, Talab, Sanam Shafaat, Claydon, Thomas W, Hove-Madsen, Leif, Tibbits, Glen F

“…Zebrafish (Danio rerio) are widely used as vertebrate model in developmental genetics and functional genomics as well as in cardiac structure-function studies…”
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Functional Divergence in Teleost Cardiac Troponin Paralogs Guides Variation in the Interaction of TnI Switch Region with TnC by Genge, Christine E, Stevens, Charles M, Davidson, William S, Singh, Gurpreet, Peter Tieleman, D, Tibbits, Glen F

“…Gene duplication results in extra copies of genes that must coevolve with their interacting partners in multimeric protein complexes. The cardiac troponin (Tn)…”
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Structural Analysis of a Monomeric Form of the Twin-Arginine Leader Peptide Binding Chaperone Escherichia coli DmsD by Stevens, Charles M., Winstone, Tara M.L., Turner, Raymond J., Paetzel, Mark

“…The redox enzyme maturation proteins play an essential role in the proofreading and membrane targeting of protein substrates to the twin-arginine translocase…”
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Identification of Residues in DmsD for Twin-Arginine Leader Peptide Binding, Defined through Random and Bioinformatics-Directed Mutagenesis by Chan, Catherine S, Winstone, Tara M. L, Chang, Limei, Stevens, Charles M, Workentine, Matthew L, Li, Haiming, Wei, Ying, Ondrechen, Mary J, Paetzel, Mark, Turner, Raymond J

“…The twin-arginine translocase (Tat) system is used for the targeting and translocation of folded proteins across the cell membrane of most bacteria. Substrates…”
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OMLeT—An Alternative Approach to Learning Metabolism: Glycolysis and the TCA Cycle as an Example by Surette, Michael G, Stevens, Charles M, Silver, Dylan M, Behm, Brad, Turner, Raymond J

“…The techniques and learning styles used by students to learn metabolism are as varied as the topics in biology. Given the technological advancement of…”
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Potential of Mean Force Calculations and Isothermal Titration Calorimetry Measurements of the Human Cardiac Troponin C / Calcium Interaction Reveal Affinity Changes as a Function of Familial Hypertrophic Cardiomyopathy Associated Mutations by Stevens, Charles M., Rayani, Kaveh, Singh, Gurpreet, Tieleman, D. Peter, Tibbits, Glen F.

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Thermodynamics of Calcium Binding to Zebrafish Troponin C (TnC) Visualized through Isothermal Titration Calorimetry (ITC) and Molecular Dynamics (MD) by Rayani, Kaveh, Stevens, Charles M., Liang, Bo, Genge, Christine E., Tibbits, Glen F.

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Molecular Dynamics-Based Predictions of the Structural and Functional Effects of Disease-Causing Cardiac Troponin Mutations by Lotfalisalmasi, Bairam, Stevens, Charles M., Tibbits, Glen F.

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Solar Neutrinos: Proposal for a New Test by Freedman, Melvin S., Stevens, Charles M., Horwitz, E. Philip, Fuchs, Louis H., Lerner, Jerome L., Goodman, Leonard S., Childs, William J., Hessler, Jan

“…The predicted flux on the earth of solar neutrinos has eluded detection, confounding current ideas of solar energy production by nuclear fusion. The dominant…”
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Molecular Dynamics-Based Predictions of the Structural and Functional Differences Between the Cardiac and Novel Slow-Skeletal Isoforms of Zebrafish Troponin C by Stevens, Charles M., Genge, Christine E., Li, Cindy, Tibbits, Glen F.

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Changes in the dynamics of the cardiac troponin C molecule explain the effects of Ca 2+ -sensitizing mutations by Stevens, Charles M, Rayani, Kaveh, Singh, Gurpreet, Lotfalisalmasi, Bairam, Tieleman, D Peter, Tibbits, Glen F

“…Cardiac troponin C (cTnC) is the regulatory protein that initiates cardiac contraction in response to Ca TnC binding Ca initiates a cascade of protein-protein…”
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1H, 13C and 15N resonance assignments and peptide binding site chemical shift perturbation mapping for the Escherichia coli redox enzyme chaperone DmsD by Stevens, Charles M., Okon, Mark, McIntosh, Lawrence P., Paetzel, Mark

“…Herein are reported the mainchain 1 H, 13 C and 15 N chemical shift assignments and amide 15 N relaxation data for Escherichia coli DmsD, a 23.3 kDa protein…”
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super(1)H, super(13)C and super(15)N resonance assignments and peptide binding site chemical shift perturbation mapping for the Escherichia coli redox enzyme chaperone DmsD by Stevens, Charles M, Okon, Mark, McIntosh, Lawrence P, Paetzel, Mark

“…Herein are reported the mainchain super(1)H, super(13)C and super(15)N chemical shift assignments and amide super(15)N relaxation data for Escherichia coli…”
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sup 1^H, ^sup 13^C and ^sup 15^N resonance assignments and peptide binding site chemical shift perturbation mapping for the Escherichia coli redox enzyme chaperone DmsD by Stevens, Charles M, Okon, Mark, Mcintosh, Lawrence P, Paetzel, Mark

“…Herein are reported the mainchain ^sup 1^H, ^sup 13^C and ^sup 15^N chemical shift assignments and amide ^sup 15^N relaxation data for Escherichia coli DmsD, a…”
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