Search Results - "Stevens, Amy O."

Benchmarking the Accuracy of AlphaFold 2 in Loop Structure Prediction by Stevens, Amy O., He, Yi

“…The inhibition of protein–protein interactions is a growing strategy in drug development. In addition to structured regions, many protein loop regions are…”
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Allosterism in the PDZ Family by Stevens, Amy O, He, Yi

“…Dynamic allosterism allows the propagation of signal throughout a protein. The PDZ (PSD-95/Dlg1/ZO-1) family has been named as a classic example of dynamic…”
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Molecular Dynamics Reveal Key Steps in BAR-Related Membrane Remodeling by Song, Shenghan, Li, Tongtong, Stevens, Amy O, Shorty, Temair, He, Yi

“…Endocytosis plays a complex role in pathogen-host interactions. It serves as a pathway for pathogens to enter the host cell and acts as a part of the immune…”
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Three Binding Conformations of BIO124 in the Pocket of the PICK1 PDZ Domain by Stevens, Amy O., Luo, Samuel, He, Yi

“…The PDZ family has drawn attention as possible drug targets because of the domains’ wide ranges of function and highly conserved binding pockets. The PICK1 PDZ…”
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Residue-Level Contact Reveals Modular Domain Interactions of PICK1 Are Driven by Both Electrostatic and Hydrophobic Forces by Stevens, Amy O, He, Yi

“…PICK1 is a multi-domain scaffolding protein that is uniquely comprised of both a PDZ domain and a BAR domain. While previous experiments have shown that the…”
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Key Factors Regulating the Interdomain Dynamics May Contribute to the Assembly of ASC by Li, Tongtong, Gil Pineda, Laura I, Stevens, Amy O, He, Yi

“…The canonical ASC domains, PYD and CARD, are interconnected by a lengthy, semi-flexible linker. The molecular basis and purpose of ASC's highly dynamic feature…”
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Investigating the allosteric response of the PICK1 PDZ domain to different ligands with all‐atom simulations by Stevens, Amy O., Kazan, I. Can, Ozkan, Banu, He, Yi

“…The PDZ family is comprised of small modular domains that play critical roles in the allosteric modulation of many cellular signaling processes by binding to…”
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AlphaFold illuminates half of the dark human proteins by Binder, Jessica L., Berendzen, Joel, Stevens, Amy O., He, Yi, Wang, Jian, Dokholyan, Nikolay V., Oprea, Tudor I.

“…We investigate the use of confidence scores to evaluate the accuracy of a given AlphaFold (AF2) protein model for drug discovery. Prediction of accuracy is…”
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Recognizing the Binding Pattern and Dissociation Pathways of the p300 Taz2-p53 TAD2 Complex by Li, Tongtong, Motta, Stefano, Stevens, Amy O., Song, Shenghan, Hendrix, Emily, Pandini, Alessandro, He, Yi

“…The dynamic association and dissociation between proteins are the basis of cellular signal transduction. This process becomes much more complicated if one or…”
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Emulsion‐Induced Polymersomes Taming Tetrodotoxin for Prolonged Duration Local Anesthesia by Li, Xiaosi, Li, Qi, Song, Shenghan, Stevens, Amy O., Broemmel, Zach, He, Yi, Wesselmann, Ursula, Yaksh, Tony, Zhao, Chao

“…Injectable local anesthetics that can provide a continuous nerve block approximating the duration of a pain state would be a life‐changing solution for…”
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Comparing Interpersonal Interactions with a Virtual Human to Those with a Real Human by Raij, Andrew B., Johnsen, Kyle, Dickerson, Robert F., Lok, Benjamin C., Cohen, Marc S., Duerson, Margaret, Pauly, Rebecca Rainer, Stevens, Amy O., Wagner, Peggy, Lind, D. Scott

“…This paper provides key insights into the construction and evaluation of interpersonal simulators-systems that enable interpersonal interaction with virtual…”
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Fetal fibronectin and bacterial vaginosis are associated with preterm birth in women who are symptomatic for preterm labor by Stevens, Amy O, Chauhan, Suneet P, Magann, Everett F, Martin, Rick W, Bofill, James A, Cushman, Julie L, Morrison, John C

“…The purpose of this study was to codify the relationship between bacterial vaginosis/fetal fibronectin and preterm labor/birth. In this prospective study, 185…”
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Emulsion‐Induced Polymersomes Taming Tetrodotoxin for Prolonged Duration Local Anesthesia (Adv. Therap. 1/2023) by Li, Xiaosi, Li, Qi, Song, Shenghan, Stevens, Amy O., Broemmel, Zach, He, Yi, Wesselmann, Ursula, Yaksh, Tony, Zhao, Chao

“…In article number 2200199, Chao Zhao and co‐workers report emulsion‐induced polymersomes. Through a simple emulsification process, the polymer forms…”
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Comparing Interpersonal Interactions with a Virtual Human to Those with a Real Human by Raij, A B, Johnsen, K, Dickerson, R F, Lok, B C, Cohen, M S, Duerson, M, Pauly, R R, Stevens, A O, Wagner, P, Lind, D S

“…Nonverbal behavior appeared to communicate lower interest and a poorer attitude toward the virtual human…”
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Fetal fibronectin and bacterial vaginosis are associated with preterm birth in women who are symptomatic for preterm labor. Discussion by STEVENS, Amy O, CHAUHAN, Suneet P, MAGANN, Everett F, MARTIN, Rick W, BOFILL, James A, CUSHMAN, Julie L, MORRISON, John C, MARTENS, Mark G, NEERHOF, Mark

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