Search Results - "Stevens, Aaron J."

Widespread genomic de novo DNA methylation occurs following CD8 + T cell activation and proliferation by Seddon, Annika R, Damiano, Olivia M, Hampton, Mark B, Stevens, Aaron J

“…This research investigates the intricate dynamics of DNA methylation in the hours following CD8+ T cell activation, during a critical yet understudied temporal…”
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Structural Analysis of G-Quadruplex Formation at the Human MEST Promoter by Stevens, Aaron J, Kennedy, Martin A

“…The promoter region of the imprinted gene MEST contains several motifs capable of forming G-quadruplex (G4) structures, which appear to contribute to…”
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G-quadruplex structures and CpG methylation cause drop-out of the maternal allele in polymerase chain reaction amplification of the imprinted MEST gene promoter by Stevens, Aaron J, Stuffrein-Roberts, Selma, Cree, Simone L, Gibb, Andrew, Miller, Allison L, Doudney, Kit, Aitchison, Alan, Eccles, Michael R, Joyce, Peter R, Filichev, Vyacheslav V, Kennedy, Martin A

“…We observed apparent non-Mendelian behaviour of alleles when genotyping a region in a CpG island at the 5' end of the maternally imprinted human MEST isoform…”
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[Letter to the Editor] Many commercial hot-start polymerases demonstrate activity prior to thermal activation by Stevens, Aaron J, Appleby, Sarah, Kennedy, Martin A

“…Address correspondence to Martin A. Kennedy, Department of Pathology & Carney Centre for Pharmacogenomics, University of Otago, Christchurch, PO Box 4345,…”
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Genome-wide impact of hydrogen peroxide on maintenance DNA methylation in replicating cells by Seddon, Annika R, Liau, Yusmiati, Pace, Paul E, Miller, Allison L, Das, Andrew B, Kennedy, Martin A, Hampton, Mark B, Stevens, Aaron J

“…Environmental factors, such as oxidative stress, have the potential to modify the epigenetic landscape of cells. We have previously shown that DNA…”
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Allelic Dropout During Polymerase Chain Reaction due to G-Quadruplex Structures and DNA Methylation Is Widespread at Imprinted Human Loci by Stevens, Aaron J, Taylor, Millie G, Pearce, Frederick Grant, Kennedy, Martin A

“…Loss of one allele during polymerase chain reaction (PCR) amplification of DNA, known as allelic dropout, can be caused by a variety of mechanisms. Allelic…”
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Epigenetic changes associated with Bacillus Calmette-Guerin (BCG) treatment in bladder cancer by Picard, Lucy C., Rich, Fenella J., Kenwright, Diane N., Stevens, Aaron J.

“…Bacillus Calmette-Guérin (BCG) treatment for non-muscle invasive bladder cancer (NMIBC) is an established immunotherapeutic, however, a significant portion of…”
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Site-specific decreases in DNA methylation in replicating cells following exposure to oxidative stress by Seddon, Annika R, Das, Andrew B, Hampton, Mark B, Stevens, Aaron J

“…Oxidative stress is a common feature of inflammation-driven cancers, and it promotes genomic instability and aggressive tumour phenotypes. It is known that…”
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Human gut microbiome changes during a 10 week Randomised Control Trial for micronutrient supplementation in children with attention deficit hyperactivity disorder by Stevens, Aaron J., Purcell, Rachel V., Darling, Kathryn A., Eggleston, Matthew J. F., Kennedy, Martin A., Rucklidge, Julia J.

“…It has been widely hypothesized that both diet and the microbiome play a role in the regulation of attention-deficit/hyperactivity disorder (ADHD) behaviour…”
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Methylated Cytosine Maintains G‑Quadruplex Structures during Polymerase Chain Reaction and Contributes to Allelic Dropout by Stevens, Aaron J, Kennedy, Martin A

“…The promoter of the human imprinted gene MEST is differentially methylated with respect to the parent of origin and contains several non B-DNA motifs that are…”
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Randomised control trial indicates micronutrient supplementation may support a more robust maternal microbiome for women with antenatal depression during pregnancy by Stevens, Aaron J., Heiwari, Thalia M., Rich, Fenella J., Bradley, Hayley A., Gur, Tamar L., Galley, Jeffrey D., Kennedy, Martin A., Dixon, Lesley A., Mulder, Roger T., Rucklidge, Julia J.

“…We investigated the effects of high dose dietary micronutrient supplementation or placebo on the human gut microbiome in pregnant women who had moderate…”
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Epigenetics, nutrition and mental health. Is there a relationship? by Stevens, Aaron J., Rucklidge, Julia J., Kennedy, Martin A.

“…Many aspects of human development and disease are influenced by the interaction between genetic and environmental factors. Understanding how our genes respond…”
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Can we predict treatment response in children with ADHD to a vitamin-mineral supplement? An investigation into pre-treatment nutrient serum levels, MTHFR status, clinical correlates and demographic variables by Rucklidge, Julia J., Eggleston, Matthew J.F., Darling, Kathryn A., Stevens, Aaron J., Kennedy, Martin A., Frampton, Christopher M.

“…Intent-to-treat analyses from a randomized controlled trial showed significant between-group differences favouring micronutrient treatment on the Clinical…”
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Circular replication-associated protein encoding DNA viruses identified in the faecal matter of various animals in New Zealand by Steel, Olivia, Kraberger, Simona, Sikorski, Alyssa, Young, Laura M., Catchpole, Ryan J., Stevens, Aaron J., Ladley, Jenny J., Coray, Dorien S., Stainton, Daisy, Dayaram, Anisha, Julian, Laurel, van Bysterveldt, Katherine, Varsani, Arvind

“…In recent years, innovations in molecular techniques and sequencing technologies have resulted in a rapid expansion in the number of known viral sequences, in…”
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The Driver of Extreme Human-Specific Olduvai Repeat Expansion Remains Highly Active in the Human Genome by Heft, Ilea E, Mostovoy, Yulia, Levy-Sakin, Michal, Ma, Walfred, Stevens, Aaron J, Pastor, Steven, McCaffrey, Jennifer, Boffelli, Dario, Martin, David I, Xiao, Ming, Kennedy, Martin A, Kwok, Pui-Yan, Sikela, James M

“…Abstract Olduvai (formerly DUF1220) protein domains have undergone the largest human-specific increase in copy number of any coding region in the genome (∼300…”
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Fluorescence Methods for Probing G‑Quadruplex Structure in Single- and Double-Stranded DNA by Stevens, Aaron J, Kennedy, Hannah L, Kennedy, Martin A

“…Interest in exploring G-quadruplex (G4) structures in nucleic acids is growing as it becomes more widely recognized that these structures have many interesting…”
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Author Correction: Human gut microbiome changes during a 10 week Randomised Control Trial for micronutrient supplementation in children with attention deficit hyperactivity disorder by Stevens, Aaron J., Purcell, Rachel V., Darling, Kathryn A., Eggleston, Matthew J. F., Kennedy, Martin A., Rucklidge, Julia J.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Methylomic changes in response to micronutrient supplementation and MTHFR genotype by Stevens, Aaron J, Rucklidge, Julia J, Darling, Kathryn A, Eggleston, Matthew Jf, Pearson, John F, Kennedy, Martin A

“…Exposure times and dosage required for dietary components to modify DNA methylation patterns are largely unknown. This exploratory research represents the…”
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Methylomic changes in response to micronutrient supplementation and by Stevens, Aaron J, Rucklidge, Julia J, Darling, Kathryn A, Eggleston, Matthew JF, Pearson, John F, Kennedy, Martin A

“…Exposure times and dosage required for dietary components to modify DNA methylation patterns are largely unknown. This exploratory research represents the…”
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The Driver of Extreme Human-Specific Olduvai Repeat Expansion Remains Highly Active in the Human Genome by Heft, Ilea E, Mostovoy, Yulia, Levy-Sakin, Michal, Ma, Walfred, Stevens, Aaron J, Pastor, Steven, McCaffrey, Jennifer, Boffelli, Dario, Martin, David I, Xiao, Ming, Kennedy, Martin A, Kwok, Pui-Yan, Sikela, James M

“…Olduvai (formerly DUF1220) protein domains have undergone the largest human-specific increase in copy number of any coding region in the genome (∼300 copies of…”
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