Search Results - "Steven Zheng, X.F."

Dynamic monitoring of antimicrobial resistance using magnesium zinc oxide nanostructure-modified quartz crystal microbalance by Reyes, Pavel Ivanoff, Yang, Keyang, Zheng, Andrew, Li, Rui, Li, Guangyuan, Lu, Yicheng, Tsang, Chi Kwan, Zheng, Steven X.F.

“…Antimicrobial resistance (AMR) is becoming a major global-health concern prompting an urgent need for highly-sensitive and rapid diagnostic technology…”
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Expanding roles of superoxide dismutases in cell regulation and cancer by Che, Meixia, Wang, Ren, Li, Xiaoxing, Wang, Hui-Yun, Zheng, X.F. Steven

“…•Superoxide dismutases (SODs) have important regulatory functions in metabolism, signalling and transcription.•SODs are crucial for cancer cell growth,…”
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Role of RNA polymerase III transcription and regulation in ischaemic stroke by Tsang, Chi Kwan, Zheng, X F Steven

“…Ischaemic stroke is a leading cause of death and life-long disability due to neuronal cell death resulting from interruption of glucose and oxygen supplies…”
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mTOR regulates aerobic glycolysis through NEAT1 and nuclear paraspeckle-mediated mechanism in hepatocellular carcinoma by Zhang, Hong, Su, Xiaoyang, Burley, Stephen K, Zheng, X F Steven

“…Hepatocellular Carcinoma (HCC) is a major form of liver cancer and a leading cause of cancer-related death worldwide. New insights into HCC pathobiology and…”
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mTORC1 Promotes ARID1A Degradation and Oncogenic Chromatin Remodeling in Hepatocellular Carcinoma by Zhang, Shanshan, Zhou, Yu-Feng, Cao, Jian, Burley, Stephen K, Wang, Hui-Yun, Zheng, X F Steven

“…The SWI/SNF chromatin remodeling complexes control accessibility of chromatin to transcriptional and coregulatory machineries. Chromatin remodeling plays…”
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SOD1 Phosphorylation by mTORC1 Couples Nutrient Sensing and Redox Regulation by Tsang, Chi Kwan, Chen, Miao, Cheng, Xin, Qi, Yanmei, Chen, Yin, Das, Ishani, Li, Xiaoxing, Vallat, Brinda, Fu, Li-Wu, Qian, Chao-Nan, Wang, Hui-Yun, White, Eileen, Burley, Stephen K., Zheng, X.F. Steven

“…Nutrients are not only organic compounds fueling bioenergetics and biosynthesis, but also key chemical signals controlling growth and metabolism. Nutrients…”
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Targeting the mTOR kinase domain: the second generation of mTOR inhibitors by Zhang, Yan-Jie, Duan, Yanwen, Zheng, X.F. Steven

“…The mTOR signaling pathway is dysregulated in ∼50% of all human malignancies and is a major cancer drug target. Although rapamycin analogs (rapalogs) have…”
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mTOR binds to the promoters of RNA polymerase I- and III-transcribed genes by Tsang, Chi Kwan, Liu, Hui, Zheng, X.F. Steven

“…Target of rapamycin (TOR) is a conserved regulator of gene expression from yeast to humans. In budding yeast, TOR is associated with ribosomal DNA (rDNA)…”
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MAF1 suppresses AKT‐mTOR signaling and liver cancer through activation of PTEN transcription by Li, Yue, Tsang, Chi Kwan, Wang, Suihai, Li, Xiao‐Xing, Yang, Yang, Fu, Liwu, Huang, Wenlin, Li, Ming, Wang, Hui‐Yun, Zheng, X.F. Steven

“…The phosphatidylinositol 3‐kinase/phosphatidylinositol 3,4,5‐trisphosphate 3‐phosphatase/protein kinase B/mammalian target of rapamycin (PI3K‐PTEN‐AKT‐mTOR)…”
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Beyond regulation of pol III: Role of MAF1 in growth, metabolism, aging and cancer by Zhang, Shanshan, Li, Xiaoxing, Wang, Hui-Yun, Steven Zheng, X.F.

“…MAF1 was discovered as a master repressor of Pol III-dependent transcription in response to diverse extracellular signals, including growth factor, nutrient…”
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mTOR-independent 4E-BP1 phosphorylation is associated with cancer resistance to mTOR kinase inhibitors by Zhang, Yanjie, Zheng, X.F. Steven

“…ATP -competitive mTO R kinase inhibitors (mTorKIs) are a new generation of mTO R-targeted agents with more potent anticancer activity than rapamycin in several…”
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Targeting mammalian target of rapamycin (mTOR) for health and diseases by Tsang, Chi Kwan, Qi, Haiyan, Liu, Leroy F., Zheng, X.F. Steven

“…The macrolide rapamycin is used clinically to treat graft rejection and restenosis. Mammalian target of rapamycin (mTOR) is a central controller of cellular…”
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Amino acids control blood glucose levels through mTOR signaling by Fan, Jialin, Yuan, Ziqiang, Burley, Stephen K., Libutti, Steven K., Zheng, X.F. Steven

“…Amino Acids are not only major nutrient sources, but also serve as chemical signals to control cellular growth. Rab1A recently emerged as a key component in…”
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Clinical Significance and Prognostic Value of microRNA Expression Signatures in Hepatocellular Carcinoma by RONGRONG WEI, HUANG, Guo-Liang, STEVEN ZHENG, X. F, YUAN, Yun-Fei, WANG, Hui-Yun, ZHANG, Mei-Yin, LI, Bin-Kui, ZHANG, Hui-Zhong, MING SHI, CHEN, Xiao-Qian, LONG HUANG, ZHOU, Qing-Ming, JIA, Wei-Hua

“…MicroRNAs (miRNAs) play important roles in the development and progression of cancer. The aim of this study is to identify miRNA expression signatures in…”
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Aberrant amino acid signaling promotes growth and metastasis of hepatocellular carcinomas through Rab1A-dependent activation of mTORC1 by Rab1A by Xu, Bi-Hong, Li, Xiao-Xing, Yang, Yang, Zhang, Mei-Yin, Rao, Hui-Lan, Wang, Hui-Yun, Zheng, X F Steven

“…mTORC1 is a master regulator of cell growth and proliferation, and an established anticancer drug target. Aberrant mTORC1 signaling is common in hepatocellular…”
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Maf1 is an intrinsic suppressor against spontaneous neural repair and functional recovery after ischemic stroke by Tsang, Chi Kwan, Mi, Qiongjie, Su, Guangpu, Hwa Lee, Gum, Xie, Xuemin, D'Arcangelo, Gabriella, Huang, Li'an, Steven Zheng, X.F.

“…[Display omitted] •MAF1 is a novel intrinsic inhibitor of spontaneous recovery after ischemic stroke.•MAF1 is upregulated and activated in neurons of…”
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Targeting mTOR as a novel therapeutic strategy for traumatic CNS injuries by Arachchige Don, Aruni S., Tsang, Chi Kwan, Kazdoba, Tatiana M., D’Arcangelo, Gabriella, Young, Wise, Steven Zheng, X.F.

“…► We provide a brief overview of CNS injuries and current therapies. ► Currently few therapies are available to treat severe CNS injuries. ► Emerging evidence…”
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Maf1 controls retinal neuron number by both RNA Pol III- and Pol II-dependent mechanisms by Li, Yifei, Xiao, Dongchang, Chen, Haiqiao, Zheng, X.F. Steven, Xiang, Mengqing

“…The generation of appropriate numbers and types of neurons is a prerequisite for assembling functional neural circuits. However, the molecular basis regulating…”
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Nuclear mTOR Signaling Orchestrates Transcriptional Programs Underlying Cellular Growth and Metabolism by Zhao, Tinghan, Fan, Jialin, Abu-Zaid, Ahmed, Burley, Stephen K, Zheng, X F Steven

“…mTOR is a central regulator of cell growth and metabolism in response to mitogenic and nutrient signals. Notably, mTOR is not only found in the cytoplasm but…”
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Sch9 partially mediates TORC1 signaling to control ribosomal RNA synthesis by Wei, Yuehua, Zheng, X.F. Steven

“…TORC1 is a central regulator of ribosomal RNA synthesis. Here we report that Sch9 partially mediates TORC1 signaling to regulate Pol I- and Pol III-dependent…”
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