Search Results - "Steven R. Fuhrmann"

Healthy individuals have T-cell and antibody responses to the tumor antigen cyclin B1 that when elicited in mice protect from cancer by Vella, Laura A, Yu, Min, Fuhrmann, Steven R, El-Amine, Moustapha, Epperson, Diane E, Finn, Olivera J

“…We previously identified the aberrantly expressed cell cycle regulator cyclin B1 as a tumor antigen recognized by antibodies and T cells from patients with…”
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CD8+ T-cell Immune Evasion Enables Oncolytic Virus Immunotherapy by Pourchet, Aldo, Fuhrmann, Steven R., Pilones, Karsten A., Demaria, Sandra, Frey, Alan B., Mulvey, Matthew, Mohr, Ian

“…Although counteracting innate defenses allows oncolytic viruses (OVs) to better replicate and spread within tumors, CD8+ T-cells restrict their capacity to…”
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Delineation of stage specific expression of Plasmodium falciparum EBA-175 by biologically functional region II monoclonal antibodies by Sim, B Kim Lee, Narum, David L, Chattopadhyay, Rana, Ahumada, Adriana, Haynes, J David, Fuhrmann, Steven R, Wingard, Jennifer N, Liang, Hong, Moch, J Kathleen, Hoffman, Stephen L

“…The malaria parasite Plasmodium falciparum EBA-175 binds its receptor sialic acids on glycophorin A when invading erythrocytes. The receptor-binding region…”
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Protection of Aotus Monkeys by Plasmodium falciparum EBA-175 Region II DNA Prime—Protein Boost Immunization Regimen by Jones, Trevor R., Narum, David L., Gozalo, Alfonso S., Aguiar, Joao, Fuhrmann, Steven R., Liang, Hong, Haynes, J. David, Moch, J. Kathleen, Lucas, Carmen, Luu, Tin, Magill, Alan J., Hoffman, Stephen L., Sim, B. K. L.

“…Aotus monkeys received 4 doses of Plasmodium falciparum EBA-175 region II vaccine as plasmid DNA (Dv-Dv) or recombinant protein in adjuvant (Pv-Pv) or as 3…”
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Genomic abnormalities of the murine model of Fabry disease after disease-related perturbation, a systems biology approach by Moore, David F, Gelderman, Monique P, Ferreira, Paulo A, Fuhrmann, Steven R, Yi, Haiqing, Elkahloun, Abdel, Lix, Lisa M, Brady, Roscoe O, Schiffmann, Raphael, Goldin, Ehud

“…Fabry disease is a disorder of α-D-galactosyl-containing glycolipids resulting from a deficiency of α-galactosidase A. Patients have a poorly understood…”
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GM1 Binding-Deficient Exotoxin Is a Potent Noninflammatory Broad Spectrum Intradermal Immunoadjuvant by Zoeteweij, J. Paul, Epperson, Diane E, Porter, Jackie D, Zhang, Chen X, Frolova, Olga Y, Constantinides, Anita P, Fuhrmann, Steven R, El-Amine, Moustapha, Tian, Jing-Hui, Ellingsworth, Larry R, Glenn, Gregory M

“…Intradermal (i.d.) immunization is a promising route of vaccine administration. Suitable i.d. adjuvants are important to increase vaccine efficacy in poorly…”
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A novel fusion protein containing the receptor binding domains of C. difficile toxin A and toxin B elicits protective immunity against lethal toxin and spore challenge in preclinical efficacy models by Tian, Jing-Hui, Fuhrmann, Steven R, Kluepfel-Stahl, Stefanie, Carman, Robert J, Ellingsworth, Larry, Flyer, David C

“…Highlights ► C. difficile ToxinA:toxin B fusion protein. ► Induction of toxin neutralizing antibody. ► Immunoprotection against an in vivo C. difficile spore…”
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Codon optimization of gene fragments encoding Plasmodium falciparum merzoite proteins enhances DNA vaccine protein expression and immunogenicity in mice by NARUM, David L, KUMAR, Sanjai, ROGERS, William O, FUHRMANN, Steven R, HONG LIANG, OAKLEY, Miranda, TAYE, Alem, KIM LEE SIM, B, HOFFMAN, Stephen L

“…In contrast to conventional vaccines, DNA and other subunit vaccines exclusively utilize host cell molecules for transcription and translation of proteins. The…”
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A novel Plasmodium falciparum erythrocyte binding protein-2 (EBP2/BAEBL) involved in erythrocyte receptor binding by Narum, David L, Fuhrmann, Steven R, Luu, Tin, Sim, B.Kim Lee

“…The 175-kDa erythrocyte binding protein (EBA-175) of Plasmodium falciparum and Duffy antigen binding proteins of P. vivax and P. knowlesi are members of a…”
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Fabry disease and vascular risk factors: future strategies for patient-based studies and the knockout murine model by Moore, David F, Gelderman, Monique P, Fuhrmann, Steven R, Schiffmann, Raphael, Brady, Roscoe O, Goldin, Ehud

“…Fabry disease is secondary to deficiency of the lysosomal enzyme alpha-galactosidase A, leading to altered glycosphingolipid metabolism and accumulation that…”
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Absence of antigenic competition in Aotus monkeys immunized with Plasmodium falciparum DNA vaccines delivered as a mixture by Jones, Trevor R, Gramzinski, Robert A, Aguiar, Joao C, Sim, B.Kim Lee, Narum, David L, Fuhrmann, Steven R, Kumar, Sanjai, Obaldia, Nicanor, Hoffman, Stephen L

“…Aotus lemurinus lemurinus monkeys were immunized four times with one of three DNA plasmids expressing important Plasmodium falciparum blood stage vaccine…”
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Induction of biologically active antibodies in mice, rabbits, and monkeys by Plasmodium falciparum EBA-175 region II DNA vaccine by Sim, B K, Narum, D L, Liang, H, Fuhrmann, S R, Obaldia, 3rd, N, Gramzinski, R, Aguiar, J, Haynes, J D, Moch, J K, Hoffman, S L

“…Plasmodium falciparum merozoites bind to and invade human erythrocytes via specific erythrocyte receptors. This establishes the erythrocytic stage of the…”
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A novel fusion protein containing the receptor binding domains ofC. difficiletoxin A and toxin B elicits protective immunity against lethal toxin and spore challenge in preclinical efficacy models by Tian, Jing-Hui, Fuhrmann, Steven R, Kluepfel-Stahl, Stefanie, Carman, Robert J, Ellingsworth, Larry, Flyer, David C

“…Highlights *C. difficileToxinA:toxin B fusion protein. * Induction of toxin neutralizing antibody. * Immunoprotection against anin vivo C. difficilespore…”
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Endostatin binds tropomyosin. A potential modulator of the antitumor activity of endostatin by MacDonald, N J, Shivers, W Y, Narum, D L, Plum, S M, Wingard, J N, Fuhrmann, S R, Liang, H, Holland-Linn, J, Chen, D H, Sim, B K

“…The mechanism of action of Endostatin, an endogenous inhibitor of angiogenesis and tumor growth, remains unknown. We utilized phage-display technology to…”
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Fabry disease and vascular risk factors: future strategies for patient-based studies and the knockout murine model by Moore, David F., Gelderman, Monique P., Fuhrmann, Steven R., Schiffmann, Raphael, Brady, Roscoe O., Goldin, Ehud

“…Fabry disease is secondary to deficiency of the lysosomal enzyme α‐galactosidase A, leading to altered glycosphingolipid metabolism and accumulation that is…”
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Neutrophilic Myeloperoxidase–Macrophage Interactions Perpetuate Chronic Inflammation Associated with Experimental Arthritis by Lefkowitz, Doris L., Gelderman, Monique P., Fuhrmann, Steven R., Graham, Suzanne, Starnes, Joel D., Lefkowitz, Stanley S., Bollen, Alex, Moguilevsky, Nicole

“…Rheumatoid arthritis is a systemic disease of unknown etiology. The purpose of this study was to elucidate an unrecognized interaction between neutrophilic…”
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A recombinant baculovirus-expressed Plasmodium falciparum receptor-binding domain of erythrocyte binding protein EBA-175 biologically mimics native protein by HONG LIANG, NARUM, D. L, FUHRMANN, S. R, TIN LUU, KIM LEE SIM, B

“…EBA-175 of Plasmodium falciparum is a merozoite ligand that binds its receptor glycophorin A on erythrocytes during invasion. The ligand-receptor interaction…”
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A Recombinant Baculovirus-ExpressedPlasmodium falciparum Receptor-Binding Domain of Erythrocyte Binding Protein EBA-175 Biologically Mimics Native Protein by Hong Liang, David L. Narum, Steven R. Fuhrmann, Tin Luu, B. Kim Lee Sim

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Codon Optimization of Gene Fragments EncodingPlasmodium falciparum Merzoite Proteins Enhances DNA Vaccine Protein Expression and Immunogenicity in Mice by David L. Narum, Sanjai Kumar, William O. Rogers, Steven R. Fuhrmann, Hong Liang, Miranda Oakley, Alem Taye, B. Kim Lee Sim, Stephen L. Hoffman

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Endostatin Binds Tropomyosin by MacDonald, NicholasJ, Shivers, WandaY, Narum, DavidL, Plum, StacyM, Wingard, JenniferN, Fuhrmann, StevenR, Liang, Hong, Holland-Linn, Janel, Chen, D.H.Tom, Sim, B. Kim Lee

“…The mechanism of action of Endostatin, an endogenous inhibitor of angiogenesis and tumor growth, remains unknown. We utilized phage-display technology to…”
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