Search Results - "Steven M. Ruben"

Use of an Immunoaffinity-Mass Spectrometry-based Approach for the Quantification of Protein Biomarkers from Serum Samples of Lung Cancer Patients by Nicol, Gordon R., Han, Mark, Kim, Jun, Birse, Charles E., Brand, Erin, Nguyen, Anh, Mesri, Mehdi, FitzHugh, William, Kaminker, Patrick, Moore, Paul A., Ruben, Steven M., He, Tao

“…It is a challenging task to verify and quantify potential biomarkers expressed at elevated levels in sera from cancer patients. An immunoaffinity-mass…”
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Immune modulator CD70 as a potential cisplatin resistance predictive marker in ovarian cancer by Aggarwal, Sudeepta, He, Tao, FitzHugh, William, Rosenthal, Kim, Feild, Brian, Heidbrink, Jenny, Mesmer, Deborah, Ruben, Steven M, Moore, Paul A

“…Abstract Objective We have used mass-spectrometry (MS) based proteomics platform to identify cell surface proteins over-expressed on a cisplatin resistant…”
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Mutations of two P/WS homologues in hereditary nonpolyposis colon cancer by Nicolaides, Nicholas C, Papadopoulos, Nickolas, Liu, Bo, Weit, Ying-Fei, Carter, Kenneth C, Ruben, Steven M, Rosen, Craig A, Haseltine, William A, Fleischmann, Robert D, Fraser, Claire M, Adams, Mark D, Venter, J. Craig, Dunlop, Malcolm G, Hamilton, Stanley R, Petersen, Gloria M, de la Chapelle, Albert, Vogelstein, Bert, Kinzler, Kenneth W

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Cloning and sequencing of human Eppin: A novel family of protease inhibitors expressed in the epididymis and testis by Richardson, Richard T, Sivashanmugam, Perumal, Hall, Susan H, Hamil, Katherine G, Moore, Paul A, Ruben, Steven M, French, Frank S, O'Rand, Michael

“…In this report we describe the discovery of Eppin ( Epididymal protease inhibitor), a gene on human chromosome 20 expressing three mRNAs encoding two isoforms…”
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BLyS: Member of the Tumor Necrosis Factor Family and B Lymphocyte Stimulator by Moore, Paul A., Belvedere, Ornella, Orr, Amy, Pieri, Krystyna, LaFleur, David W., Feng, Ping, Soppet, Daniel, Charters, Meghan, Gentz, Reiner, Parmelee, David, Li, Yuling, Galperina, Olga, Giri, Judith, Roschke, Viktor, Nardelli, Bernardetta, Carrell, Jeffrey, Sosnovtseva, Svetlana, Greenfield, Wilbert, Ruben, Steven M., Olsen, Henrik S., Fikes, James, Hilbert, David M.

“…The tumor necrosis factor (TNF) superfamily of cytokines includes both soluble and membrane-bound proteins that regulate immune responses. A member of the…”
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RNA interference characterization of proteins discovered by proteomic analysis of pancreatic cancer reveals function in cell growth and survival by Lee, Candy N, Heidbrink, Jenny L, McKinnon, Katherine, Bushman, Victoria, Olsen, Henrik, FitzHugh, William, Li, Aiqun, Van Orden, Karen, He, Tao, Ruben, Steven M, Moore, Paul A

“…There is a clear need for better therapeutics and diagnostics for pancreatic cancer. We aimed to discover plasma membrane-associated proteins overexpressed in…”
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Reproducibility Assessment of Relative Quantitation Strategies for LC−MS Based Proteomics by Kim, Yeoun Jin, Zhan, Ping, Feild, Brian, Ruben, Steven M, He, Tao

“…The reproducibility of a given method for relative quantitation governs the reliability of liquid chromatography−mass spectrometry (LC−MS) based differential…”
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Reference map for liquid chromatography–mass spectrometry-based quantitative proteomics by Kim, Yeoun Jin, Feild, Brian, FitzHugh, William, Heidbrink, Jenny L., Duff, James W., Heil, Jeremy, Ruben, Steven M., He, Tao

“…The accurate mass and time (AMT) tag strategy has been recognized as a powerful tool for high-throughput analysis in liquid chromatography–mass spectrometry…”
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Antibacterial properties of the sperm-binding proteins and peptides of human epididymis 2 (HE2) family; salt sensitivity, structural dependence and their interaction with outer and cytoplasmic membranes of Escherichia coli by Yenugu, Suresh, Hamil, Katherine G, Birse, Charles E, Ruben, Steven M, French, Frank S, Hall, Susan H

“…During passage through the epididymis, sperm interact with secreted epididymal proteins that promote maturation, including the acquisition of motility and…”
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Mutation of a mutL Homolog in Hereditary Colon Cancer by Papadopoulos, Nickolas, Nicolaides, Nicholas C., Wei, Ying-Fei, Ruben, Steven M., Carter, Kenneth C., Rosen, Craig A., Haseltine, William A., Fleischmann, Robert D., Fraser, Claire M., Adams, Mark D., Venter, J. Craig, Hamilton, Stanley R., Petersen, Gloria M., Watson, Patrice, Lynch, Henry T., Peltomäki, Päivi, Mecklin, Jukka-Pekka, de la Chapelle, Albert, Kinzler, Kenneth W., Vogelstein, Bert

“…Some cases of hereditary nonpolyposis colorectal cancer (HNPCC) are due to alterations in a mutS-related mismatch repair gene. A search of a large database of…”
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TRAIL (Apo-2L) and TRAIL Receptors in Human Placentas: Implications for Immune Privilege by Phillips, Teresa A, Ni, Jian, Pan, Guohua, Ruben, Steven M, Wei, Ying-Fei, Pace, Judith L, Hunt, Joan S

“…Mechanisms accounting for protection of the fetal semiallograft from maternal immune cells remain incompletely understood. In other contexts, interactions…”
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HE2β and HE2γ, New Members of an Epididymis-Specific Family of Androgen-Regulated Proteins in the Human by Hamil, Katherine G., Sivashanmugam, P., Richardson, Richard T., Grossman, Gail, Ruben, Steven M., Mohler, James L., Petrusz, Peter, O’Rand, Michael G., French, Frank S., Hall, Susan H.

“…Abstract HE2 is an epididymis-specific sperm-binding secretory protein. We isolated a family of HE2-related complementary DNAs from a human caput/corpus…”
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Isolation of a rel-Related Human cDNA That Potentially Encodes the 65-kD Subunit of NF-κB by Ruben, Steven M., Dillon, Patrick J., Schreck, Ralf, Henkel, Thomas, Chen, Chein-Hwa, Maher, Maureen, Baeuerle, Patrick A., Rosen, Craig A.

“…A DNA probe that spanned a domain conserved among the proto-oncogene c-rel, the Drosophila morphogen dorsal, and the p50 DNA binding subunit of NF-κB was…”
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The Type 1 Human Immunodeficiency Virus Tat Binding Protein is a Transcriptional Activator Belonging to an Additional Family of Evolutionarily Conserved Genes by Ohana, Bella, Moore, Paul A., Ruben, Steven M., Southgate, Christopher D., Green, Michael R.

“…The type 1 human immunodeficiency virus Tat protein is a powerful transcriptional activator when bound to an RNA structure (TAR) present at the extreme 5'…”
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Identification of a Naturally Occurring Transforming Variant of the p65 Subunit of NF-κB by Narayanan, Ramaswamy, Klement, John F., Ruben, Steven M., Higgins, Kimberly A., Rosen, Craig A.

“…Transcription factor NF-κB comprises two proteins, p50 and p65, that have sequence similarity to the v-rel oncogene. In primary hematopoietic cell populations…”
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Interferon-κ, a Novel Type I Interferon Expressed in Human Keratinocytes by LaFleur, David W., Nardelli, Bernardetta, Tsareva, Tatiana, Mather, Don, Feng, Ping, Semenuk, Mark, Taylor, Kara, Buergin, Markus, Chinchilla, Diana, Roshke, Viktor, Chen, Guoxian, Ruben, Steven M., Pitha, Paula M., Coleman, Timothy A., Moore, Paul A.

“…High throughput cDNA sequencing has led to the identification of interferon-κ, a novel subclass of type I interferon that displays ∼30% homology to other…”
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Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation by KUNSCH, C, RUBEN, S. M, ROSEN, C. A

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IκB interacts with the nuclear localization sequences of the subunits of NF-κB: a mechanism for cytoplasmic retention by BEG, A. A, RUBEN, S. M, SCHEINMAN, R. I, HASKILL, S, ROSEN, C. A, BALDWIN, A. S

“…NF-kappa B is an inducible transcription factor comprised of a 50-kD (p50) and a 65-kD (p65) subunit. Induction of NF-kappa B activity, which is a critical…”
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Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis by Quelle, Frederick W., Shimoda, Kazuya, Thierfelder, William, Fischer, Carrie, Kim, Ann, Ruben, Steven M., Cleveland, John L., Pierce, Jacalyn H., Keegan, Achsah D., Nelms, Keats, Paul, William E., Ihle, James N.

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Functional characterization of the NF-kappa B p65 transcriptional activator and an alternatively spliced derivative by RUBEN, S. M, NARAYANAN, R, KLEMENT, J. F, CHIEN-HWA CHEN, ROSEN, C. A

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