Search Results - "Steven J. DeMarco"

Inhibition of complement C5 protects against organ failure and reduces mortality in a baboon model of Escherichia coli sepsis by Keshari, Ravi Shankar, Silasi, Robert, Popescu, Narcis Ioan, Patel, Maulin Mukeshchandra, Chaaban, Hala, Lupu, Cristina, Coggeshall, K. Mark, Mollnes, Tom Eirik, DeMarco, Steven J., Lupu, Florea

“…Bacterial sepsis triggers robust activation of the complement system with subsequent generation of anaphylatoxins (C3a, C5a) and the terminal complement…”
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Plasma Membrane Ca2+ ATPase Isoform 2b Interacts Preferentially with Na+/H+ Exchanger Regulatory Factor 2 in Apical Plasma Membranes by DeMarco, Steven J., Chicka, Michael C., Strehler, Emanuel E.

“…Spatial and temporal regulation of Ca2+ signaling require the assembly of multiprotein complexes linking molecules involved in Ca2+ influx, sensing, buffering,…”
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AAV2-hAADC (Eladocagene Exuparvovec) Biodistribution and Expression: Superiority of Intraputaminal versus Intracerebroventricular and Intrathecal (Lumbar) Routes of Administration by Compton, David R, DeMarco, Steven J, Yalamanchili, Padmaja

“…Aromatic L-amino acid decarboxylase deficiency is a genetic disorder of enzyme loss with decreased neurotransmitter synthesis, and it is characterized by…”
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Bradykinin and ATP Accelerate Ca2+ Efflux from Rat Sensory Neurons via Protein Kinase C and the Plasma Membrane Ca2+ Pump Isoform 4 by Usachev, Yuriy M., DeMarco, Steven J., Campbell, Colin, Strehler, Emanuel E., Thayer, Stanley A.

“…Modulation of Ca2+channels by neurotransmitters provides critical control of neuronal excitability and synaptic strength. Little is known about regulation of…”
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Peptidomimetic Antibiotics Target Outer-Membrane Biogenesis in Pseudomonas aeruginosa by Srinivas, Nityakalyani, Jetter, Peter, Ueberbacher, Bernhard J, Werneburg, Martina, Zerbe, Katja, Steinmann, Jessica, Van der Meijden, Benjamin, Bernardini, Francesca, Lederer, Alexander, Dias, Ricardo L.A, Misson, Pauline E, Henze, Heiko, Zumbrunn, Jürg, Gombert, Frank O, Obrecht, Daniel, Hunziker, Peter, Schauer, Stefan, Ziegler, Urs, Käch, Andres, Eberl, Leo, Riedel, Kathrin, DeMarco, Steven J, Robinson, John A

“…Antibiotics with new mechanisms of action are urgently required to combat the growing health threat posed by resistant pathogenic microorganisms. We…”
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Cell-specific expression of plasma membrane calcium ATPase isoforms in retinal neurons by Krizaj, David, Demarco, Steven J., Johnson, Juliette, Strehler, Emanuel E., Copenhagen, David R.

“…Ca2+ extrusion by high‐affinity plasma membrane calcium ATPases (PMCAs) is a principal mechanism for the clearance of Ca2+ from the cytosol. The PMCA family…”
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Plasma Membrane Ca2+-ATPase Isoforms 2b and 4b Interact Promiscuously and Selectively with Members of the Membrane-associated Guanylate Kinase Family of PDZ (PSD95/Dlg/ZO-1) Domain-containing Proteins by DeMarco, Steven J., Strehler, Emanuel E.

“…Spatial and temporal regulation of intracellular Ca2+ signaling depends on localized Ca2+ microdomains containing the requisite molecular components for Ca2+…”
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Discovery of novel, highly potent and selective β-hairpin mimetic CXCR4 inhibitors with excellent anti-HIV activity and pharmacokinetic profiles by DeMarco, Steven J., Henze, Heiko, Lederer, Alexander, Moehle, Kerstin, Mukherjee, Reshmi, Romagnoli, Barbara, Robinson, John A., Brianza, Federico, Gombert, Frank O., Lociuro, Sergio, Ludin, Christian, Vrijbloed, Jan Willem, Zumbrunn, Jürg, Obrecht, Jean-Pierre, Obrecht, Daniel, Brondani, Vincent, Hamy, François, Klimkait, Thomas

“…Protein epitope mimetics (PEM) of Polyphemusin II act as highly potent CXCR4 inhibitors with good in vivo pharmacokinetic properties. Novel highly potent CXCR4…”
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Bradykinin and ATP accelerate Ca(2+) efflux from rat sensory neurons via protein kinase C and the plasma membrane Ca(2+) pump isoform 4 by Usachev, Yuriy M, DeMarco, Steven J, Campbell, Colin, Strehler, Emanuel E, Thayer, Stanley A

“…Modulation of Ca(2+) channels by neurotransmitters provides critical control of neuronal excitability and synaptic strength. Little is known about regulation…”
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Plasma Membrane Ca2+ ATPase Isoform 4b Binds to Membrane-associated Guanylate Kinase (MAGUK) Proteins via Their PDZ (PSD-95/Dlg/ZO-1) Domains by Kim, Eunjoon, DeMarco, Steven J., Marfatia, Shirin M., Chishti, Athar H., Sheng, Morgan, Strehler, Emanuel E.

“…Plasma membrane Ca2+ ATPases are P-type pumps important for intracellular Ca2+homeostasis. The extreme C termini of alternatively spliced “b”-type Ca2+ pump…”
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Characterization of PISP, a Novel Single-PDZ Protein That Binds to All Plasma Membrane Ca2+-ATPase b-Splice Variants by GOELLNER, GEOFFREY M., DEMARCO, STEVEN J., STREHLER, EMANUEL E.

“…: Plasma membrane Ca2+ ATPases (PMCAs) maintain intracellular Ca2+ homeostasis and participate in the local regulation of Ca2+ signaling. Spatially separate…”
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Discovery of Highly Potent and Selective CXCR4 Inhibitors Using Protein Epitope Mimetics (PEM) Technology by Alexander Lederer, John A. Robinson, Kerstin Moehle, Thomas Klimkait, François Hamy, Vincent Brondani, Sergio Lociuro, Jean-Pierre Obrecht, Jan Willem Vrijbloed, Christian Ludin, Frank O. Gombert, Federico Brianza, Jürg Zumbrunn, Reshmi Mukherjee, Barbara Romagnoli, Heiko Henze, Steven J. DeMarco, Daniel Obrecht

“…Novel, highly potent CXCR4 inhibitors with good pharmacokinetic properties were obtained by applying PEM technology starting from the naturally occurring…”
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RA101495, A Subcutaneously Administered Peptide Inhibitor of Complement Component 5 (C5) for the Treatment of Generalized Myasthenia Gravis (gMG): Phase 1 Results and Phase 2 Design (S31.006) by Howard, James F., Kaminski, Henry J., Nowak, Richard J., Wolfe, Gil I., Benatar, Michael G., Ricardo, Alonso, Hoarty, Michelle D., DeMarco, Steven J., Farzaneh-Far, Ramin, Duda, Petra W.

“…Abstract only…”
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A Novel C5 Complement Inhibitor Protects Against Sepsis-Induced Activation of Complement, Coagulation and Inflammation and Provides Survival Benefit in E. coli Sepsis by Keshari, Ravi, Silasi-Mansat, Robert, Popescu, Narcis I., Chaaban, Hala, Lupu, Cristina, DeMarco, Steven J, Lupu, Florea

“…Bacterial sepsis triggers robust early activation of the complement system that leads to the formation of the C5b-9 terminal complex (TCC) and potent…”
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Development of RA101348, a Potent Cyclic Peptide Inhibitor of C5 for Complement-Mediated Diseases by Ricardo, Alonso, Arata, Michelle, DeMarco, Steven J, Dhamnaskar, Ketki, Hammer, Robert, Josephson, Kristopher, Seyb, Kathleen, Tobe, Sylvia, Wang, Zhaolin, Zheng, Hong, Treco, Douglas

“…The involvement of complement in the pathogenesis of serious, life-threatening diseases underscores the importance in developing therapeutics to intervene in…”
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Abstract LB-304: ATSP-9172, a novel Stapled Peptide inhibitor of HIF-dependent transcriptional activity with in vivo antitumor efficacy in a preclinical model of prostate cancer by Sun, Kaiming, DeMarco, Steven J., Guerlavais, Vincent, Mukherjee, Aditi, Irwin, Sean, Shi, Eric, Cai, Hongliang, Darlak, Krzysztof, Santiago, Solimar, Pero, Jessica, Olson, Karen A., Nash, Huw M., Chang, Yong

“…Abstract Hypoxia-inducible transcription factors (HIF) are key regulators of cellular adaptation to hypoxia in solid tumors, and HIF-1α controls the expression…”
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Characterization of PISP, a Novel Single‐PDZ Protein That Binds to All Plasma Membrane Ca 2+ ‐ATPase b‐Splice Variants by GOELLNER, GEOFFREY M., DEMARCO, STEVEN J., STREHLER, EMANUEL E.

“…A bstract : Plasma membrane Ca 2+ ATPases (PMCAs) maintain intracellular Ca 2+ homeostasis and participate in the local regulation of Ca 2+ signaling…”
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Bradykinin and ATP Accelerate Ca 2+ Efflux from Rat Sensory Neurons via Protein Kinase C and the Plasma Membrane Ca 2+ Pump Isoform 4 by Usachev, Yuriy M., DeMarco, Steven J., Campbell, Colin, Strehler, Emanuel E., Thayer, Stanley A.

“…Modulation of Ca 2+ channels by neurotransmitters provides critical control of neuronal excitability and synaptic strength. Little is known about regulation of…”
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Primary structure of human plasma membrane Ca2+-ATPase isoform 3 by Brown, Billie Jo, Hilfiker, Helene, DeMarco, Steven J., Zacharias, David A., Greenwood, Tammy M., Guerini, Danilo, Strehler, Emanuel E.

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Primary structure of human plasma membrane Ca 2+-ATPase isoform 3 by Brown, Billie Jo, Hilfiker, Helene, DeMarco, Steven J., Zacharias, David A., Greenwood, Tammy M., Guerini, Danilo, Strehler, Emanuel E.

“…The complete coding sequence of the human plasma membrane calcium ATPase (PMCA) isoform 3 was determined from overlapping genomic and cDNA clones. The cDNAs…”
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