Search Results - "Steven, Coats"

Synthesis of Nucleoside Phosphate and Phosphonate Prodrugs by Pradere, Ugo, Garnier-Amblard, Ethel C, Coats, Steven J, Amblard, Franck, Schinazi, Raymond F

“…Pradere et al examine the synthesis of nucleoside phosphate and phosphonate prodrugs…”
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A database of North American double modals and self-repairs from YouTube by Coats, Steven

“…Sequences of two modal verbs in spoken English can represent use of a nonstandard syntactic feature (double modal) or a corrected utterance in which a speaker…”
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Antibody-Drug Conjugates: Future Directions in Clinical and Translational Strategies to Improve the Therapeutic Index by Coats, Steven, Williams, Marna, Kebble, Benjamin, Dixit, Rakesh, Tseng, Leo, Yao, Nai-Shun, Tice, David A, Soria, Jean-Charles

“…Since the first approval of gemtuzumab ozogamicin (Mylotarg; Pfizer; CD33 targeted), two additional antibody-drug conjugates (ADC), brentuximab vedotin…”
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A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy by Li, John Y., Perry, Samuel R., Muniz-Medina, Vanessa, Wang, Xinzhong, Wetzel, Leslie K., Rebelatto, Marlon C., Hinrichs, Mary Jane Masson, Bezabeh, Binyam Z., Fleming, Ryan L., Dimasi, Nazzareno, Feng, Hui, Toader, Dorin, Yuan, Andy Q., Xu, Lan, Lin, Jia, Gao, Changshou, Wu, Herren, Dixit, Rakesh, Osbourn, Jane K., Coats, Steven R.

“…Antibody-drug conjugate (ADC) which delivers cytotoxic drugs specifically into targeted cells through internalization and lysosomal trafficking has emerged as…”
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HIV nucleoside reverse transcriptase inhibitors by Amblard, Franck, Patel, Dharmeshkumar, Michailidis, Eleftherios, Coats, Steven J., Kasthuri, Mahesh, Biteau, Nicolas, Tber, Zahira, Ehteshami, Maryam, Schinazi, Raymond F.

“…More than 40 years into the pandemic, HIV remains a global burden and as of now, there is no cure in sight. Fortunately, highly active antiretroviral therapy…”
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Synthesis of (2S)‑2-Chloro-2-fluororibolactone via Stereoselective Electrophilic Fluorination by De Schutter, Coralie, Sari, Ozkan, Coats, Steven J, Amblard, Franck, Schinazi, Raymond F

“…A novel and efficient route for the preparation of (2S)-2-chloro-2-fluorolactone 29 is described. This approach takes advantage of a highly efficient…”
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HER2-targeted antibody-drug conjugate induces host immunity against cancer stem cells by Xia, Leiming, Wen, Lu, Qin, You, Dobson, Hannah E, Zhang, Tao, Comer, Frank I, Hinrichs, Mary Jane, Oberst, Michael D, Coats, Steven R, Chang, Alfred E, Liu, Yuanyuan, Bao, Yangyi, Dai, Fu, Wicha, Max S, Li, Qiao

“…We previously tested HER2-targeted antibody-drug conjugates (ADCs) in immunocompromised (SCID) mice, precluding evaluation of host immunity, impact on cancer…”
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A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy by Li, John Y., Perry, Samuel R., Muniz-Medina, Vanessa, Wang, Xinzhong, Wetzel, Leslie K., Rebelatto, Marlon C., Masson Hinrichs, Mary Jane, Bezabeh, Binyam Z., Fleming, Ryan L., Dimasi, Nazzareno, Feng, Hui, Toader, Dorin, Yuan, Andy Q., Xu, Lan, Lin, Jia, Gao, Changshou, Wu, Herren, Dixit, Rakesh, Osbourn, Jane K., Coats, Steven R.

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Synthesis and antiviral evaluation of novel heteroarylpyrimidines analogs as HBV capsid effectors by Boucle, Sebastien, Lu, Xiao, Bassit, Leda, Ozturk, Tugba, Russell, Olivia Ollinger, Amblard, Franck, Coats, Steven J., Schinazi, Raymond F.

“…[Display omitted] New modifications to the scaffold of previously reported HBV capsid assembly effectors such as BAY 41-4109, HAP-12 and GLS4 were explored…”
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Synthesis and anti-HCV activity of β-d-2′-deoxy-2′-α-chloro-2′-β-fluoro and β-d-2′-deoxy-2′-α-bromo-2′-β-fluoro nucleosides and their phosphoramidate prodrugs by Ovadia, Reuben, Khalil, Ahmed, Li, Hao, De Schutter, Coralie, Mengshetti, Seema, Zhou, Shaoman, Bassit, Leda, Coats, Steven J., Amblard, Franck, Schinazi, Raymond F.

“…[Display omitted] We report herein the synthesis and evaluation of a series of β-d-2′-deoxy-2′-α-chloro-2′-β-fluoro and β-d-2′-deoxy-2′-α-bromo-2′-β-fluoro…”
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2′-Chloro,2′-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture by Zhou, Shaoman, Mahmoud, Sawsan, Liu, Peng, Zhou, Longhu, Ehteshami, Maryam, Bassit, Leda, Tao, Sijia, Domaoal, Robert A, Sari, Ozkan, Schutter, Coralie De, Amiralaei, Sheida, Khalil, Ahmed, Ollinger Russell, Olivia, McBrayer, Tamara, Whitaker, Tony, Abou-Taleb, Nageh, Amblard, Franck, Coats, Steven J, Schinazi, Raymond F

“…Pan-genotypic nucleoside HCV inhibitors display a high genetic barrier to drug resistance and are the preferred direct-acting agents to achieve complete…”
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Synthesis of carbocyclic nucleoside analogs with five-membered heterocyclic nucleobases by Cho, Jong hyun, Coats, Steven J., Schinazi, Raymond F.

“…[Display omitted] New carbocyclic nucleoside analogs with five-membered heterocyclic nucleobases were synthesized and evaluated as potential anti-HIV and…”
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Asymmetric Binding to NS5A by Daclatasvir (BMS-790052) and Analogs Suggests Two Novel Modes of HCV Inhibition by Nettles, James H, Stanton, Richard A, Broyde, Joshua, Amblard, Franck, Zhang, Hongwang, Zhou, Longhu, Shi, Junxing, McBrayer, Tamara R, Whitaker, Tony, Coats, Steven J, Kohler, James J, Schinazi, Raymond F

“…Symmetric, dimeric daclatasvir (BMS-790052) is the clinical lead for a class of picomolar inhibitors of HCV replication. While specific, resistance-bearing…”
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Azetidines and spiro azetidines as novel P2 units in hepatitis C virus NS3 protease inhibitors by Bondada, Lavanya, Rondla, Ramu, Pradere, Ugo, Liu, Peng, Li, Chengwei, Bobeck, Drew, McBrayer, Tamara, Tharnish, Philip, Courcambeck, Jerome, Halfon, Philippe, Whitaker, Tony, Amblard, Franck, Coats, Steven J., Schinazi, Raymond F.

“…Herein, we report the synthesis and structure–activity relationship studies of new analogs of boceprevir 1 and telaprevir 2. Introduction of azetidine and…”
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Synthesis and anti-HCV activity of a series of β-d-2′-deoxy-2′-dibromo nucleosides and their corresponding phosphoramidate prodrugs by Chen, Zhe, Cox, Bryan D., Garnier-Amblard, Ethel C., McBrayer, Tamara R., Coats, Steven J., Schinazi, Raymond F., Amblard, Franck

“…[Display omitted] Several β-d-2′-deoxy-2′-substituted nucleoside analogs have displayed potent and selective anti-HCV activities and some of them have reached…”
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Synthesis and antiviral evaluation of 2′,2′,3′,3′-tetrafluoro nucleoside analogs by Sari, Ozkan, Bassit, Leda, Gavegnano, Christina, McBrayer, Tamara R., McCormick, Louise, Cox, Bryan, Coats, Steven J., Amblard, Franck, Schinazi, Raymond F.

“…[Display omitted] •The synthesis of novel 2′,2′,3′,3′-tetrafluoro nucleoside analogs is described.•Glycosylation reactions are achieved via Mitsunobu…”
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A Therapeutic Uricase with Reduced Immunogenicity Risk and Improved Development Properties by Nyborg, Andrew C, Ward, Chris, Zacco, Anna, Chacko, Benoy, Grinberg, Luba, Geoghegan, James C, Bean, Ryan, Wendeler, Michaela, Bartnik, Frank, O'Connor, Ellen, Gruia, Flaviu, Iyer, Vidyashankara, Feng, Hui, Roy, Varnika, Berge, Mark, Miner, Jeffrey N, Wilson, David M, Zhou, Dongmei, Nicholson, Simone, Wilker, Clynn, Wu, Chi Y, Wilson, Susan, Jermutus, Lutz, Wu, Herren, Owen, David A, Osbourn, Jane, Coats, Steven, Baca, Manuel

“…Humans and higher primates are unique in that they lack uricase, the enzyme capable of oxidizing uric acid. As a consequence of this enzyme deficiency, humans…”
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Discovery of a Series of 2′-α-Fluoro,2′-β-bromo-ribonucleosides and Their Phosphoramidate Prodrugs as Potent Pan-Genotypic Inhibitors of Hepatitis C Virus by Mengshetti, Seema, Zhou, Longhu, Sari, Ozkan, De Schutter, Coralie, Zhang, Hongwang, Cho, Jong Hyun, Tao, Sijia, Bassit, Leda C, Verma, Kiran, Domaoal, Robert A, Ehteshami, Maryam, Jiang, Yong, Ovadia, Reuben, Kasthuri, Mahesh, Ollinger Russell, Olivia, McBrayer, Tamara, Whitaker, Tony, Pattassery, Judy, Pascual, Maria Luz, Uher, Lothar, Lin, Biing Y, Lee, Sam, Amblard, Franck, Coats, Steven J, Schinazi, Raymond F

“…Hepatitis C virus (HCV) nucleoside inhibitors display pan-genotypic activity, a high barrier to the selection of resistant virus, and are some of the most…”
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Dual IGF-I/II-Neutralizing Antibody MEDI-573 Potently Inhibits IGF Signaling and Tumor Growth by JIN GAO, CHESEBROUGH, Jon W, COATS, Steven, BOSSLET, Klaus, CHANG, Yong S, CARTLIDGE, Susan A, RICKETTS, Sally-Ann, INCOGNITO, Leonard, VELDMAN-JONES, Margaret, BLAKEY, David C, TABRIZI, Mohammad, JALLAL, Bahija, TRAIL, Pamela A

“…Insulin-like growth factors (IGF), IGF-I and IGF-II, are small polypeptides involved in regulating cell proliferation, survival, differentiation, and…”
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Synthesis of 5′-Methylene-Phosphonate Furanonucleoside Prodrugs: Application to D‑2′-Deoxy-2′-α-fluoro-2′-β‑C‑methyl Nucleosides by Pradere, Ugo, Amblard, Franck, Coats, Steven J, Schinazi, Raymond F

“…A new and facile synthetic pathway to metabolically stable 5′-methylene-bis(pivaloyloxymethyl)(POM)phosphonate furanonucleoside prodrugs is reported. The key…”
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