Search Results - "Steve Quiros"

Artesunate induces oxidative DNA damage, sustained DNA double-strand breaks, and the ATM/ATR damage response in cancer cells by Berdelle, Nicole, Nikolova, Teodora, Quiros, Steve, Efferth, Thomas, Kaina, Bernd

“…Artesunate, the active agent from Artemisia annua L. used in the traditional Chinese medicine, is being applied as a first-line drug for malaria treatment, and…”
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Rad51 and BRCA2--New molecular targets for sensitizing glioma cells to alkylating anticancer drugs by Quiros, Steve, Roos, Wynand Paul, Kaina, Bernd

“…First line chemotherapeutics for brain tumors (malignant gliomas) are alkylating agents such as temozolomide and nimustine. Despite growing knowledge of how…”
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Survival and death strategies in glioma cells: autophagy, senescence and apoptosis triggered by a single type of temozolomide-induced DNA damage by Knizhnik, Anna V, Roos, Wynand P, Nikolova, Teodora, Quiros, Steve, Tomaszowski, Karl-Heinz, Christmann, Markus, Kaina, Bernd

“…Apoptosis, autophagy, necrosis and cellular senescence are key responses of cells that were exposed to genotoxicants. The types of DNA damage triggering these…”
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Gene dosage compensation: Origins, criteria to identify compensated genes, and mechanisms including sensor loops as an emerging systems‐level property in cancer by Bravo‐Estupiñan, Diana M., Aguilar‐Guerrero, Karol, Quirós, Steve, Acón, Man‐Sai, Marín‐Müller, Christian, Ibáñez‐Hernández, Miguel, Mora‐Rodríguez, Rodrigo A.

“…The gene dosage compensation hypothesis presents a mechanism through which the expression of certain genes is modulated to compensate for differences in the…”
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Sphingolipid pathway as a biosensor of cancer chemosensitivity: a proof of principle by José Arturo Molina-Mora, Susana Mesen-Porras, Isaac Quiros-Fernandez, Mariana Kop-Montero, Andrea Rojas-Cespedes, Steve Quiros, Francisco Siles, Rodrigo Mora

“…Cancer is a complex genetic disease with reduced treatment alternatives due to tumor heterogeneity and drug multiresistance emergence. The sphingolipid (SL)…”
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Sphingolipid-Based Synergistic Interactions to Enhance Chemosensitivity in Lung Cancer Cells by Mesén-Porras, Susana, Rojas-Céspedes, Andrea, Molina-Mora, José Arturo, Vega-Baudrit, José, Siles, Francisco, Quiros, Steve, Mora-Rodríguez, Rodrigo

“…Tumor heterogeneity leads to drug resistance in cancer treatment with the crucial role of sphingolipids in cell fate and stress signaling. We analyzed…”
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Building a Personalized Cancer Treatment System by Martinez, Alexandra, López, Gustavo, Bola nos, Constantino, Alvarado, Daniel, Solano, Andrés, López, Mariana, Báez, Andrés, Quirós, Steve, Mora, Rodrigo

“…This paper reports the process by which a personalized cancer treatment system was built, following a user-centered approach. We give some background on…”
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Síndrome de Stevens-Johnson en una paciente con prueba positiva de transformación linfocitaria by Carvajal-Elizondo, Mariela, Monge-Ortega, Olga Patricia, Chinchilla-Monge, Ricardo, Quiros, Steve

“…Antecedentes: El síndrome de Stevens-Johnson es una reacción medicamentosa severa. Las sulfamidas se han asociado con reacciones medicamentosas,…”
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Isolation, characterization and molecular cloning of AnMIP, a new alpha-type phospholipase A2 myotoxin inhibitor from the plasma of the snake Atropoides nummifer (Viperidae: Crotalinae) by Quirós, Steve, Alape-Girón, Alberto, Angulo, Yamileth, Lomonte, Bruno

“…A new phospholipase A(2) (PLA(2))-inhibitory protein was isolated from the plasma of Atropoides nummifer, a crotaline snake from Central America. This…”
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Processing of O6-methylguanine into DNA double-strand breaks requires two rounds of replication whereas apoptosis is also induced in subsequent cell cycles by Quiros, Steve, Roos, Wynand P., Kaina, Bernd

“…The DNA adduct O 6 -methylguanine (O 6 MeG) induced by environmental genotoxins and anticancer drugs is a highly mutagenic, genotoxic and apoptotic lesion…”
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Processing of O 6 -methylguanine into DNA double-strand breaks requires two rounds of replication whereas apoptosis is also induced in subsequent cell cycles by Quiros, Steve, Roos, Wynand P., Kaina, Bernd

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XRCC3 contributes to temozolomide resistance of glioblastoma cells by promoting DNA double-strand break repair by Roos, Wynand P., Frohnapfel, Larissa, Quiros, Steve, Ringel, Florian, Kaina, Bernd

“…Glioblastoma is the most frequent and aggressive form of high-grade malignant glioma. Due to the dismal prognosis faced by patients suffering from this…”
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Bactericidal and Antiendotoxic Properties of Short Cationic Peptides Derived from a Snake Venom Lys49 Phospholipase A2 by Carlos Santamaría, Silda Larios, Steve Quirós, Javier Pizarro-Cerda, Jean-Pierre Gorvel, Bruno Lomonte, Edgardo Moreno

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Brca2/Xrcc2 dependent HR, but not NHEJ, is required for protection against O 6-methylguanine triggered apoptosis, DSBs and chromosomal aberrations by a process leading to SCEs by Roos, Wynand P., Nikolova, Teodora, Quiros, Steve, Naumann, Steffen C., Kiedron, Olivia, Zdzienicka, Małgorzata Z., Kaina, Bernd

“…O 6-methylguanine (O 6MeG) is a highly critical DNA adduct induced by methylating carcinogens and anticancer drugs such as temozolomide, streptozotocine,…”
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Generación de Datos de Validación para Rastreo Celular en Microscopía de Campo Claro usando Muestras Fluorescentes by Quinde-Cobos, Patricia, Quirós, Steve, Siles-Canales, Francisco

“…Este trabajo usa imágenes de fluorescencia de células cancerígenas como para validación de resultados obtenidos por segmentación de imágenes de campo claro de…”
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Brca2/Xrcc2 dependent HR, but not NHEJ, is required for protection against O(6)-methylguanine triggered apoptosis, DSBs and chromosomal aberrations by a process leading to SCEs by Roos, Wynand P, Nikolova, Teodora, Quiros, Steve, Naumann, Steffen C, Kiedron, Olivia, Zdzienicka, Małgorzata Z, Kaina, Bernd

“…O(6)-methylguanine (O(6)MeG) is a highly critical DNA adduct induced by methylating carcinogens and anticancer drugs such as temozolomide, streptozotocine,…”
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B-Raf inhibitor vemurafenib in combination with temozolomide and fotemustine in the killing response of malignant melanoma cells by Roos, Wynand P, Quiros, Steve, Krumm, Andrea, Merz, Stephanie, Switzeny, Olivier Jérôme, Christmann, Markus, Loquai, Carmen, Kaina, Bernd

“…In the treatment of metastatic melanoma, a highly therapy-refractory cancer, alkylating agents are used and, for the subgroup of BRAFV600E cancers, the B-Raf…”
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MYC dosage compensation is mediated by miRNA-transcription factor interactions in aneuploid cancer by Acón, ManSai, Geiß, Carsten, Torres-Calvo, Jorge, Bravo-Estupiñan, Diana, Oviedo, Guillermo, Arias-Arias, Jorge L., Rojas-Matey, Luis A., Edwin, Baez, Vásquez-Vargas, Gloriana, Oses-Vargas, Yendry, Guevara-Coto, José, Segura-Castillo, Andrés, Siles-Canales, Francisco, Quirós-Barrantes, Steve, Régnier-Vigouroux, Anne, Mendes, Pedro, Mora-Rodríguez, Rodrigo

“…We hypothesize that dosage compensation of critical genes arises from systems-level properties for cancer cells to withstand the negative effects of…”
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Brca2/Xrcc2 dependent HR, but not NHEJ, is required for protection against O6-methylguanine triggered apoptosis, DSBs and chromosomal aberrations by a process leading to SCEs by ROOS, Wynand P, NIKOLOVA, Teodora, QUIROS, Steve, NAUMANN, Steffen C, KIEDRON, Olivia, ZDZIENICKA, Małgorzata Z, KAINA, Bernd

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Bactericidal and Antiendotoxic Properties of Short Cationic Peptides Derived from a Snake Venom Lys49 Phospholipase A sub(2) by Santamaria, Carlos, Larios, Silda, Quiros, Steve, Pizarro-Cerda, Javier, Gorvel, Jean-Pierre, Lomonte, Bruno, Moreno, Edgardo

“…The activities of short synthetic, nonhemolytic peptides derived from the C-terminal region of myotoxin II, a catalytically inactive phospholipase A sub(2)…”
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