Search Results - "Stet, E H"

6-Mercaptopurine: cytotoxicity and biochemical pharmacology in human malignant T-lymphoblasts by Bökkerink, J P, Stet, E H, De Abreu, R A, Damen, F J, Hulscher, T W, Bakker, M A, van Baal, J A

“…The effects of prolonged exposure to 2 and 10 microM 6-mercaptopurine (6MP) in the human lymphoblastic T-cell line MOLT-4 were studied with respect to…”
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The importance of methylthio-IMP for methylmercaptopurine ribonucleoside (Me-MPR) cytotoxicity in Molt F4 human malignant T-lymphoblasts by Vogt, M H, Stet, E H, De Abreu, R A, Bökkerink, J P, Lambooy, L H, Trijbels, F J

“…The importance of methyl-thioIMP (Me-tIMP) formation for methylmercaptopurine ribonucleoside (Me-MPR) cytotoxicity was studied in Molt F4 cells. Cytotoxicity…”
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Decrease in S-adenosylmethionine synthesis by 6-mercaptopurine and methylmercaptopurine ribonucleoside in Molt F4 human malignant lymphoblasts by Stet, E H, De Abreu, R A, Bökkerink, J P, Blom, H J, Lambooy, L H, Vogels-Mentink, T M, de Graaf-Hess, A C, van Raay-Selten, B, Trijbels, F J

“…6-Mercaptopurine (6-MP) and methylmercaptopurine ribonucleoside (Me-MPR) are purine anti-metabolites which are both metabolized to methylthio-IMP (Me-tIMP), a…”
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A biochemical basis for synergism of 6-mercaptopurine and mycophenolic acid in Molt F4, a human malignant T-lymphoblastic cell line by Stet, E H, De Abreu, R A, Janssen, Y P, Bökkerink, J P, Trijbels, F J

“…6-Mercaptopurine (6MP) cytotoxicity was studied in Molt F4 cells, a T-cell acute lymphoblastic leukemia (ALL) cell line. The effects on cytotoxicity were…”
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Thiopurine treatment in childhood leukemia. Metabolic aspects and sensitivity by De Abreu, R A, Bokkerink, J P, Keuzenkamp-Jansen, C W, Stet, E H, Trijbels, J F

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Reversal of methylmercaptopurine ribonucleoside cytotoxicity by purine ribonucleosides and adenine by Stet, Elisabet H., De Abreu, Ronney A., Bökkerink, Jos P.M., Lambooy, Lambert H.J., Vogels-Mentink, Trude M., Keizer-Garritsen, Jenneke J., Trijbels, Frans J.M.

“…6-Methylmercaptopurine ribonucleoside-5′-phosphate (MeSPuRMP), the sole metabolite of 6-methylmercaptopurine ribonucleoside (MeSPuRib), is a strong inhibitor…”
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Reversal of 6-mercaptopurine and 6-methylmercaptopurine ribonucleoside cytotoxicity by amidoimidazole carboxamide ribonucleoside in Molt F4 human malignant T-lymphoblasts by Stet, E H, De Abreu, R A, Bökkerink, J P, Vogels-Mentink, T M, Lambooy, L H, Trijbels, F J, Trueworthy, R C

“…Cytotoxicity of 6-mercaptopurine (6MP) and 6-methylmercaptopurine ribonucleoside (Me-MPR) was studied in Molt F4 human malignant lymphoblasts. Both drugs are…”
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Cell-kinetics and biochemical pharmacology of methotrexate and 6-mercaptopurine in human malignant T-lymphoblasts by Bökkerink, J P, De Abreu, R A, Stet, E H, Damen, F J

“…The cell-kinetics and biochemical pharmacology of simultaneous and sequential combination treatment with 0.02 microM methotrexate (MTX) and 2 microM…”
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Inhibition of IMP dehydrogenase by mycophenolic acid in Molt F4 human malignant lymphoblasts by Stet, E H, De Abreu, R A, Bökkerink, J P, Lambooy, L H, Vogels-Mentink, T M, Keizer-Garritsen, J J, Trijbels, F J

“…The effects of inhibition of inosine monophosphate dehydrogenase (IMPDH), the rate-limiting enzyme in guanine nucleotide de novo synthesis, on cell growth,…”
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The IMP dehydrogenase inhibitor mycophenolic acid antagonizes the CTP synthetase inhibitor 3-deazauridine in MOLT-3 human leukemia cells: A central role for phosphoribosyl pyrophosphate by Van Berg, A.André, Mooyer, Petra A.W., Van Lenthe, Henk, Stet, Elisabeth H., De Abreu, Ronney A., Van Kuilenburg, AndréB.P., Van Gennip, Albert H.

“…Mycophenolic acid, an inhibitor of the enzyme IMP dehydrogenase, antagonizes the CTP synthetase inhibitor 3-deazauridine in its anti-proliferative effects on…”
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The IMP dehydrogenase inhibitor mycophenolic acid antogonizes the CTP synthetase inhibitor 3-deazauridine in molt-3 human leukemia cells : a central role for phosphoribosyl pyrophosphate by VAN BERG, A. A, MOOYER, P. A. W, VAN LENTHE, H, STET, E. H, DE ABREU, R. A, VAN KUILENBURG, A. B. P, VAN GENNIP, A. H

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6-Mercaptopurine metabolism in two leukemic cell lines by Stet, E H, De Abreu, R A, Janssen, Y P, Bökkerink, J P, Trijbels, J M

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Action and sequence dependent interaction of acivicin and 6-thioguanine in human derived malignant T-ALL and CALLA+ cell lines by Trueworthy, R C, DeAbreu, R A, Lambooy, L H, Bökkerink, J P, Stet, E H

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