Search Results - "Stertz, Silke"

TIGIT limits immune pathology during viral infections by Schorer, Michelle, Rakebrandt, Nikolas, Lambert, Katharina, Hunziker, Annika, Pallmer, Katharina, Oxenius, Annette, Kipar, Anja, Stertz, Silke, Joller, Nicole

“…Co-inhibitory pathways have a fundamental function in regulating T cell responses and control the balance between promoting efficient effector functions and…”
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Entry of influenza A virus: host factors and antiviral targets by Edinger, Thomas O, Pohl, Marie O, Stertz, Silke

“…Influenza virus is a major human pathogen that causes annual epidemics and occasional pandemics. Moreover, the virus causes outbreaks in poultry and other…”
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Breaking the Convention: Sialoglycan Variants, Coreceptors, and Alternative Receptors for Influenza A Virus Entry by Karakus, Umut, Pohl, Marie O, Stertz, Silke

“…The influenza A virus (IAV) envelope protein hemagglutinin binds α2,6- or α2,3-linked sialic acid as a host cell receptor. Bat IAV subtypes H17N10 and H18N11…”
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Antiviral potential of 3′-sialyllactose- and 6′-sialyllactose-conjugated dendritic polymers against human and avian influenza viruses by Günther, Sira Carolin, Maier, Julian David, Vetter, Janine, Podvalnyy, Nikita, Khanzhin, Nikolay, Hennet, Thierry, Stertz, Silke

“…Current treatment options for influenza virus infections in humans are limited and therefore the development of novel antivirals is of high priority…”
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Antiviral Activity of Type I, II, and III Interferons Counterbalances ACE2 Inducibility and Restricts SARS-CoV-2 by Busnadiego, Idoia, Fernbach, Sonja, Pohl, Marie O, Karakus, Umut, Huber, Michael, Trkola, Alexandra, Stertz, Silke, Hale, Benjamin G

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), is a recently emerged respiratory coronavirus…”
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Meta- and Orthogonal Integration of Influenza “OMICs” Data Defines a Role for UBR4 in Virus Budding by Tripathi, Shashank, Pohl, Marie O., Zhou, Yingyao, Rodriguez-Frandsen, Ariel, Wang, Guojun, Stein, David A., Moulton, Hong M., DeJesus, Paul, Che, Jianwei, Mulder, Lubbertus C.F., Yángüez, Emilio, Andenmatten, Dario, Pache, Lars, Manicassamy, Balaji, Albrecht, Randy A., Gonzalez, Maria G., Nguyen, Quy, Brass, Abraham, Elledge, Stephen, White, Michael, Shapira, Sagi, Hacohen, Nir, Karlas, Alexander, Meyer, Thomas F., Shales, Michael, Gatorano, Andre, Johnson, Jeffrey R., Jang, Gwen, Johnson, Tasha, Verschueren, Erik, Sanders, Doug, Krogan, Nevan, Shaw, Megan, König, Renate, Stertz, Silke, García-Sastre, Adolfo, Chanda, Sumit K.

“…Several systems-level datasets designed to dissect host-pathogen interactions during influenza A infection have been reported. However, apparent discordance…”
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An antiviral trap made of protein nanofibrils and iron oxyhydroxide nanoparticles by Palika, Archana, Armanious, Antonius, Rahimi, Akram, Medaglia, Chiara, Gasbarri, Matteo, Handschin, Stephan, Rossi, Antonella, Pohl, Marie O., Busnadiego, Idoia, Gübeli, Christian, Anjanappa, Ravi B., Bolisetty, Sreenath, Peydayesh, Mohammad, Stertz, Silke, Hale, Benjamin G., Tapparel, Caroline, Stellacci, Francesco, Mezzenga, Raffaele

“…Minimizing the spread of viruses in the environment is the first defence line when fighting outbreaks and pandemics, but the current COVID-19 pandemic…”
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SARS-CoV-2 variants reveal features critical for replication in primary human cells by Pohl, Marie O, Busnadiego, Idoia, Kufner, Verena, Glas, Irina, Karakus, Umut, Schmutz, Stefan, Zaheri, Maryam, Abela, Irene, Trkola, Alexandra, Huber, Michael, Stertz, Silke, Hale, Benjamin G

“…Since entering the human population, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2; the causative agent of Coronavirus Disease 2019 [COVID-19])…”
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Uncovering the global host cell requirements for influenza virus replication via RNAi screening by Stertz, Silke, Shaw, Megan L.

“…Influenza virus is reliant on numerous host cell functions during its replication cycle. RNA interference technology, applied on a genome-wide level, has…”
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The Mx GTPase family of interferon-induced antiviral proteins by Haller, Otto, Stertz, Silke, Kochs, Georg

“…Mx proteins are interferon-induced members of the dynamin superfamily of large GTPases. They inhibit a wide range of viruses by blocking an early stage of the…”
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Phosphoproteomic profiling of influenza virus entry reveals infection-triggered filopodia induction counteracted by dynamic cortactin phosphorylation by Hunziker, Annika, Glas, Irina, Pohl, Marie O., Stertz, Silke

“…Binding of influenza virus to its receptor triggers signaling cascades that reprogram the cell for infection. To elucidate global virus-induced changes to the…”
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Phosphoproteomic-based kinase profiling early in influenza virus infection identifies GRK2 as antiviral drug target by Yángüez, Emilio, Hunziker, Annika, Dobay, Maria Pamela, Yildiz, Soner, Schading, Simon, Elshina, Elizaveta, Karakus, Umut, Gehrig, Peter, Grossmann, Jonas, Dijkman, Ronald, Schmolke, Mirco, Stertz, Silke

“…Although annual influenza epidemics affect around 10% of the global population, current treatment options are limited and development of new antivirals is…”
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Profiling host ANP32A splicing landscapes to predict influenza A virus polymerase adaptation by Domingues, Patricia, Eletto, Davide, Magnus, Carsten, Turkington, Hannah L., Schmutz, Stefan, Zagordi, Osvaldo, Lenk, Matthias, Beer, Martin, Stertz, Silke, Hale, Benjamin G.

“…Species’ differences in cellular factors limit avian influenza A virus (IAV) zoonoses and human pandemics. The IAV polymerase, vPol, harbors evolutionary sites…”
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Unraveling virus-induced cellular signaling cascades by label-free quantitative phosphoproteomics by Hunziker, Annika, Stertz, Silke

“…Due to the low stoichiometry and highly transient nature of protein phosphorylation it is challenging to capture the dynamics and complexity of phosphorylation…”
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Human host factors required for influenza virus replication by Shaw, Megan L, Chanda, Sumit K, König, Renate, Stertz, Silke, Zhou, Yingyao, Inoue, Atsushi, Hoffmann, H. -Heinrich, Bhattacharyya, Suchita, Alamares, Judith G, Tscherne, Donna M, Ortigoza, Mila B, Liang, Yuhong, Gao, Qinshan, Andrews, Shane E, Bandyopadhyay, Sourav, De Jesus, Paul, Tu, Buu P, Pache, Lars, Shih, Crystal, Orth, Anthony, Bonamy, Ghislain, Miraglia, Loren, Ideker, Trey, García-Sastre, Adolfo, Young, John A. T, Palese, Peter

“…Influenza A virus is an RNA virus that encodes up to 11 proteins and this small coding capacity demands that the virus use the host cellular machinery for many…”
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Restriction factor screening identifies RABGAP1L-mediated disruption of endocytosis as a host antiviral defense by Fernbach, Sonja, Spieler, Eva E., Busnadiego, Idoia, Karakus, Umut, Lkharrazi, Anouk, Stertz, Silke, Hale, Benjamin G.

“…Host interferons (IFNs) powerfully restrict viruses through the action of several hundred IFN-stimulated gene (ISG) products, many of which remain…”
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Glycosylations in the globular head of the hemagglutinin protein modulate the virulence and antigenic properties of the H1N1 influenza viruses by Medina, Rafael A, Stertz, Silke, Manicassamy, Balaji, Zimmermann, Petra, Sun, Xiangjie, Albrecht, Randy A, Uusi-Kerttula, Hanni, Zagordi, Osvaldo, Belshe, Robert B, Frey, Sharon E, Tumpey, Terrence M, García-Sastre, Adolfo

“…With the global spread of the 2009 pandemic H1N1 (pH1N1) influenza virus, there are increasing worries about evolution through antigenic drift. One way…”
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The intracellular sites of early replication and budding of SARS-coronavirus by Stertz, Silke, Reichelt, Mike, Spiegel, Martin, Kuri, Thomas, Martínez-Sobrido, Luis, García-Sastre, Adolfo, Weber, Friedemann, Kochs, Georg

“…Abstract In this study, we analyzed the replication and budding sites of severe acute respiratory syndrome coronavirus (SARS-CoV) at early time points of…”
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Protection of mice against lethal challenge with 2009 H1N1 influenza A virus by 1918-like and classical swine H1N1 based vaccines by Manicassamy, Balaji, Medina, Rafael A, Hai, Rong, Tsibane, Tshidi, Stertz, Silke, Nistal-Villán, Estanislao, Palese, Peter, Basler, Christopher F, García-Sastre, Adolfo

“…The recent 2009 pandemic H1N1 virus infection in humans has resulted in nearly 5,000 deaths worldwide. Early epidemiological findings indicated a low level of…”
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Influenza A Virus Strains Differ in Sensitivity to the Antiviral Action of Mx-GTPase by DITTMANN, Jan, STERTZ, Silke, GRIMM, Daniel, STEEL, John, GARCIA-SASTRE, Adolfo, HALLER, Otto, KOCHS, Georg

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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