Search Results - "Sterne, Gabriella R"
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1
Mating activates neuroendocrine pathways signaling hunger in Drosophila females
Published in eLife (15-05-2023)“…Mated females reallocate resources to offspring production, causing changes to nutritional requirements and challenges to energy homeostasis. Although observed…”
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Journal Article -
2
Classification and genetic targeting of cell types in the primary taste and premotor center of the adult Drosophila brain
Published in eLife (02-09-2021)“…Neural circuits carry out complex computations that allow animals to evaluate food, select mates, move toward attractive stimuli, and move away from threats…”
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Journal Article -
3
Drosophila gustatory projections are segregated by taste modality and connectivity
Published in eLife (25-05-2022)“…Gustatory sensory neurons detect caloric and harmful compounds in potential food and convey this information to the brain to inform feeding decisions. To…”
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Journal Article -
4
Taste quality and hunger interactions in a feeding sensorimotor circuit
Published in eLife (06-07-2022)“…Taste detection and hunger state dynamically regulate the decision to initiate feeding. To study how context-appropriate feeding decisions are generated, we…”
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Journal Article -
5
The Drosophila homolog of APP promotes Dscam expression to drive axon terminal growth, revealing interaction between Down syndrome genes
Published in Disease models & mechanisms (01-09-2023)“…ABSTRACT Down syndrome (DS) is caused by triplication of human chromosome 21 (HSA21). Although several HSA21 genes have been found to be responsible for…”
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6
A searchable image resource of Drosophila GAL4 driver expression patterns with single neuron resolution
Published in eLife (23-02-2023)“…Precise, repeatable genetic access to specific neurons via GAL4/UAS and related methods is a key advantage of neuroscience. Neuronal targeting is typically…”
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Journal Article -
7
Dysregulated Dscam levels act through Abelson tyrosine kinase to enlarge presynaptic arbors
Published in eLife (19-05-2015)“…Increased expression of Down Syndrome Cell Adhesion Molecule (Dscam) is implicated in the pathogenesis of brain disorders such as Down syndrome (DS) and…”
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Journal Article -
8
Regulatory mechanisms underlying the differential growth of dendrites and axons
Published in Neuroscience bulletin (01-08-2014)“…A typical neuron is comprised of an information input compartment, or the dendrites, and an output compartment, known as the axon. These two compartments are…”
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9
Neural circuit mechanisms underlying context-specific halting in Drosophila
Published in Nature (London) (03-10-2024)“…Walking is a complex motor programme involving coordinated and distributed activity across the brain and the spinal cord. Halting appropriately at the correct…”
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Journal Article -
10
A Drosophila computational brain model reveals sensorimotor processing
Published in Nature (London) (03-10-2024)“…The recent assembly of the adult Drosophila melanogaster central brain connectome, containing more than 125,000 neurons and 50 million synaptic connections,…”
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Journal Article -
11
Cell-Surface Targeting of Fluorophores in Drosophila for Rapid Neuroanatomy Visualization
Published in ACS chemical neuroscience (01-03-2023)“…Visualizing neuronal anatomy often requires labor-intensive immunohistochemistry on fixed and dissected brains. To facilitate rapid anatomical staining in live…”
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Journal Article -
12
Signaling mechanisms of down syndrome cell adhesion molecule in presynaptic arbor size control
Published 01-01-2016“…Increased expression of Down Syndrome Cell Adhesion Molecule (Dscam) is implicated in the pathogenesis of two common causes of intellectual disability, Down…”
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Dissertation