Search Results - "Sternberg, Michael J."

The Phyre2 web portal for protein modeling, prediction and analysis by Kelley, Lawrence A, Mezulis, Stefans, Yates, Christopher M, Wass, Mark N, Sternberg, Michael J E

“…Phyre2 is a web-based tool for predicting and analyzing protein structure and function. Phyre2 uses advanced remote homology detection methods to build 3D…”
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Missense3D-DB web catalogue: an atom-based analysis and repository of 4M human protein-coding genetic variants by Khanna, Tarun, Hanna, Gordon, Sternberg, Michael J. E., David, Alessia

“…The interpretation of human genetic variation is one of the greatest challenges of modern genetics. New approaches are urgently needed to prioritize variants,…”
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ePlant: Visualizing and Exploring Multiple Levels of Data for Hypothesis Generation in Plant Biology by Waese, Jamie, Fan, Jim, Pasha, Asher, Yu, Hans, Fucile, Geoffrey, Shi, Ruian, Cumming, Matthew, Kelley, Lawrence A., Sternberg, Michael J., Krishnakumar, Vivek, Ferlanti, Erik, Miller, Jason, Town, Chris, Stuerzlinger, Wolfgang, Provart, Nicholas J.

“…A big challenge in current systems biology research arises when different types of data must be accessed from separate sources and visualized using separate…”
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Protein structure prediction on the Web: a case study using the Phyre server by Kelley, Lawrence A, Sternberg, Michael J E

“…Determining the structure and function of a novel protein is a cornerstone of many aspects of modern biology. Over the past decades, a number of computational…”
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3DLigandSite: predicting ligand-binding sites using similar structures by Wass, Mark N, Kelley, Lawrence A, Sternberg, Michael J.E

“…3DLigandSite is a web server for the prediction of ligand-binding sites. It is based upon successful manual methods used in the eighth round of the Critical…”
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AlloPred: prediction of allosteric pockets on proteins using normal mode perturbation analysis by Greener, Joe G, Sternberg, Michael J E

“…Despite being hugely important in biological processes, allostery is poorly understood and no universal mechanism has been discovered. Allosteric drugs are a…”
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Thienopyrimidinone Based Sirtuin‑2 (SIRT2)-Selective Inhibitors Bind in the Ligand Induced Selectivity Pocket by Sundriyal, Sandeep, Moniot, Sébastien, Mahmud, Zimam, Yao, Shang, Di Fruscia, Paolo, Reynolds, Christopher R, Dexter, David T, Sternberg, Michael J. E, Lam, Eric W.-F, Steegborn, Clemens, Fuchter, Matthew J

“…Sirtuins (SIRTs) are NAD-dependent deacylases, known to be involved in a variety of pathophysiological processes and thus remain promising therapeutic targets…”
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PINALOG: a novel approach to align protein interaction networks—implications for complex detection and function prediction by PHAN, Hang T. T, STERNBERG, Michael J. E

“…Analysis of protein-protein interaction networks (PPINs) at the system level has become increasingly important in understanding biological processes…”
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ConFunc—functional annotation in the twilight zone by Wass, Mark N., Sternberg, Michael J. E.

“…Motivation: The success of genome sequencing has resulted in many protein sequences without functional annotation. We present ConFunc, an automated Gene…”
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Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels by Chambers, John C, Kooner, Jaspal S, Zhang, Weihua, Li, Yun, Sehmi, Joban, Wass, Mark N, Zabaneh, Delilah, Hoggart, Clive, Bayele, Henry, McCarthy, Mark I, Peltonen, Leena, Freimer, Nelson B, Srai, Surjit K, Maxwell, Patrick H, Sternberg, Michael J E, Ruokonen, Aimo, Abecasis, Gonçalo, Jarvelin, Marjo-Riitta, Scott, James, Elliott, Paul

“…We carried out a genome-wide association study of hemoglobin levels in 16,001 individuals of European and Indian Asian ancestry. The most closely associated…”
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Genetic variation in SCN10A influences cardiac conduction by Chambers, John C, Kooner, Jaspal S, Zhao, Jing, Terracciano, Cesare M N, Bezzina, Connie R, Zhang, Weihua, Kaba, Riyaz, Navaratnarajah, Manoraj, Lotlikar, Amol, Sehmi, Joban S, Kooner, Manraj K, Deng, Guohong, Siedlecka, Urszula, Parasramka, Saurabh, El-Hamamsy, Ismail, Wass, Mark N, Dekker, Lukas R C, de Jong, Jonas S S G, Sternberg, Michael J E, McKenna, William, Severs, Nicholas J, de Silva, Ranil, Wilde, Arthur A M, Anand, Praveen, Yacoub, Magdi, Scott, James, Elliott, Paul, Wood, John N

“…To identify genetic factors influencing cardiac conduction, we carried out a genome-wide association study of electrocardiographic time intervals in 6,543…”
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Protein-protein interaction sites are hot spots for disease-associated nonsynonymous SNPs by David, Alessia, Razali, Rozami, Wass, Mark N., Sternberg, Michael J.E.

“…Many nonsynonymous single nucleotide polymorphisms (nsSNPs) are disease causing due to effects at protein‐protein interfaces. We have integrated a database of…”
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Insights into protein flexibility: The relationship between normal modes and conformational change upon protein-protein docking by Dobbins, Sara E, Lesk, Victor I, Sternberg, Michael J.E

“…Understanding protein interactions has broad implications for the mechanism of recognition, protein design, and assigning putative functions to uncharacterized…”
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Landscape of Pleiotropic Proteins Causing Human Disease: Structural and System Biology Insights by Ittisoponpisan, Sirawit, Alhuzimi, Eman, Sternberg, Michael J. E., David, Alessia

“…ABSTRACT Pleiotropy is the phenomenon by which the same gene can result in multiple phenotypes. Pleiotropic proteins are emerging as important contributors to…”
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Structure-based prediction of protein allostery by Greener, Joe G, Sternberg, Michael JE

“…•The structure-based prediction of allostery will realise the potential of allostery.•Modern computational methods can help predict allosteric sites and…”
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Properties of human genes guided by their enrichment in rare and common variants by Alhuzimi, Eman, Leal, Luis G., Sternberg, Michael J.E., David, Alessia

“…We analyzed 563,099 common (minor allele frequency, MAF≥0.01) and rare (MAF < 0.01) genetic variants annotated in ExAC and UniProt and 26,884 disease‐causing…”
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Functional significance of mutations in the Snf2 domain of ATRX by MITSON, Matthew, KELLEY, Lawrence A, STERNBERG, Michael J. E, HIGGS, Douglas R, GIBBONS, Richard J

“…ATRX is a member of the Snf2 family of chromatin-remodelling proteins and is mutated in an X-linked mental retardation syndrome associated with…”
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CombFunc: predicting protein function using heterogeneous data sources by Wass, Mark N, Barton, Geraint, Sternberg, Michael J E

“…Only a small fraction of known proteins have been functionally characterized, making protein function prediction essential to propose annotations for…”
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3D-Garden: a system for modelling protein–protein complexes based on conformational refinement of ensembles generated with the marching cubes algorithm by Lesk, Victor I., Sternberg, Michael J. E.

“…Motivation: Reliable structural modelling of protein–protein complexes has widespread application, from drug design to advancing our knowledge of protein…”
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Can Predicted Protein 3D Structures Provide Reliable Insights into whether Missense Variants Are Disease Associated? by Ittisoponpisan, Sirawit, Islam, Suhail A., Khanna, Tarun, Alhuzimi, Eman, David, Alessia, Sternberg, Michael J.E.

“…Knowledge of protein structure can be used to predict the phenotypic consequence of a missense variant. Since structural coverage of the human proteome can be…”
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