Search Results - "Sternberg, Anna R"

Pre-clinical evaluation of an enhanced-function factor VIII variant for durable hemophilia A gene therapy in male mice by Sternberg, Anna R., Martos-Rus, Cristina, Davidson, Robert J., Liu, Xueyuan, George, Lindsey A.

“…Durable factor VIII expression that normalizes hemostasis is an unrealized goal of hemophilia A adeno-associated virus-mediated gene therapy. Trials with…”
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Heterologous Expression, Purification, and Functional Analysis of Plasmodium falciparum Phosphatidylinositol 3′-Kinase by Hassett, Matthew R, Sternberg, Anna R, Riegel, Bryce E, Thomas, Craig J, Roepe, Paul D

“…The Plasmodium falciparum malarial parasite genome appears to encode one and only one phosphatidylinositol 3′-kinase (PI3K), and sequence analysis suggests…”
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Heterologous Expression, Purification, and Functional Analysis of the Plasmodium falciparum Phosphatidylinositol 4‑Kinase IIIβ by Sternberg, Anna R, Roepe, Paul D

“…Recently, we heterologously expressed, purified, and analyzed the function of the sole Plasmodium falciparum phosphatidylinositol 3-kinase (PI3K), found that…”
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Enhanced procoagulant activity of select hemophilia B causing factor IX variants with emicizumab by Lee, Kyumin, Chau, Julia Q., Suber, Yani B., Sternberg, Anna R., Pishko, Allyson M., George, Lindsey A., Bhoj, Vijay G., Doshi, Bhavya S., Samelson-Jones, Benjamin J.

“…Emicizumab improves the procoagulant activity of select loss-of-function factor IX (FIX) variants with likely dysfunctional assembly of the intrinsic Xase…”
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Inhibition of Human Class I vs Class III Phosphatidylinositol 3′-Kinases by Hassett, Matthew R, Sternberg, Anna R, Roepe, Paul D

“…Most investigations of phosphatidylinositol 3′-kinase (PI3K) drug inhibition have been via assays based on ADP appearance or ATP consumption (e.g., Liu, Q., et…”
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Epilepsy-on-a-Chip System for Antiepileptic Drug Discovery by Liu, Jing, Sternberg, Anna R., Ghiasvand, Shabnam, Berdichevsky, Yevgeny

“…Objective: Hippocampal slice cultures spontaneously develop chronic epilepsy several days after slicing and are used as an in vitro model of post-traumatic…”
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Torin 2 Derivative, NCATS-SM3710, Has Potent Multistage Antimalarial Activity through Inhibition of P. falciparum Phosphatidylinositol 4‑Kinase (Pf PI4KIIIβ) by Krishnan, Karthik, Ziniel, Peter, Li, Hao, Huang, Xiuli, Hupalo, Daniel, Gombakomba, Nita, Guerrero, Sandra Mendoza, Dotrang, Thoai, Lu, Xiao, Caridha, Diana, Sternberg, Anna R, Hughes, Emma, Sun, Wei, Bargieri, Daniel Y, Roepe, Paul D, Sciotti, Richard J, Wilkerson, Matthew D, Dalgard, Clifton L, Tawa, Gregory J, Wang, Amy Q, Xu, Xin, Zheng, Wei, Sanderson, Philip E, Huang, Wenwei, Williamson, Kim C

“…Drug resistance is a constant threat to malaria control efforts making it important to maintain a good pipeline of new drug candidates. Of particular need are…”
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Inhibiting Activated Protein C Cleavage of Factor VIII for Hemophilia a Gene Therapy by Sternberg, Anna R., Martos-Rus, Cristina, Davidson, Robert J., Novak, Noelle C., Wilhelm, Amelia R., George, Lindsey A.

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Factor VIII Mimetic Rescue of Hemophilia B Causing Factor IX Variants by Lee, Kyumin, Chau, Julia Q, Sternberg, Anna R, Pishko, Allyson M, George, Lindsey, Samelson-Jones, Ben J

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