Search Results - "Stern, Ralph H"

The New Hypertension Guidelines by Stern, Ralph H

“…The Canadian Hypertension Education Program (CHEP) has published guidelines annually since 2000. The CHEP guidelines are a model of concise, comprehensive,…”
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Correspondence on “Management of individuals with germline pathogenic/likely pathogenic variants in CHEK2: A clinical practice resource of the American College of Medical Genetics and Genomics (ACMG)” by Hanson et al by Stern, Ralph H.

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Locally Informed Simulation to Predict Hospital Capacity Needs During the COVID-19 Pandemic by Stern, Ralph H

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Problems With Modified Framingham Risk Score by Stern, Ralph H., PhD, MD

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Do Risk-Enhancing Factors Enhance Risk Estimation? by Stern, Ralph H., Brook, Robert D.

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Avasimibe induces CYP3A4 and multiple drug resistance protein 1 gene expression through activation of the pregnane X receptor by Sahi, Jasminder, Milad, Mark A, Zheng, Xianxian, Rose, Kelly A, Wang, Hongbing, Stilgenbauer, Linda, Gilbert, Darryl, Jolley, Summer, Stern, Ralph H, LeCluyse, Edward L

“…In vitro and clinical studies were conducted to characterize the potential of avasimibe, an acyl-CoA/cholesterol acyltransferase inhibitor to cause drug-drug…”
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Apolipoprotein B and nuclear magnetic resonance particle number by Stern, Ralph H

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The role of nicotinic acid metabolites in flushing and hepatotoxicity by Stern, Ralph H., PhD, MD

“…Abstract Flushing and hepatotoxicity are important adverse effects of nicotinic acid. This article reviews the role of metabolism of nicotinic acid in the…”
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Individual Risk by Stern, Ralph H.

“…J Clin Hypertens (Greenwich). 2012;14:261–264. ©2012 Wiley Periodicals, Inc. Patients don’t have an “individual risk” or unique probability of an outcome…”
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Erythromycin Coadministration Increases Plasma Atorvastatin Concentrations by Siedlik, Paul H., Olson, Stephen C., Yang, Bing-Bing, Stern, Ralph H.

“…The effect of erythromycin on the pharmacokinetics of atorvastatin, an inhibitor of HMG‐CoA reductase, was investigated in 12 healthy volunteers. Each subject…”
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A human MUTYH variant linking colonic polyposis to redox degradation of the [4Fe4S]2+ cluster by McDonnell, Kevin J., Chemler, Joseph A., Bartels, Phillip L., O’Brien, Elizabeth, Marvin, Monica L., Ortega, Janice, Stern, Ralph H., Raskin, Leon, Li, Guo-Min, Sherman, David H., Barton, Jacqueline K., Gruber, Stephen B.

“…The human DNA repair enzyme MUTYH excises mispaired adenine residues in oxidized DNA. Homozygous MUTYH mutations underlie the autosomal, recessive cancer…”
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Re: "Improvement of risk prediction by genomic profiling: reclassification measures versus the area under the receiver operating characteristic curve" by Stern, Ralph H

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Evaluating New Cardiovascular Risk Factors for Risk Stratification by Stern, Ralph H.

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Nocebo Responses to Antihypertensive Medications by Stern, Ralph H.

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Are risk stratification tables the best way to evaluate model performance? by Stern, Ralph H, Smith, Dean E

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EFFECTS OF AVASIMIBE ON CYTOCHROME P450 2C9 EXPRESSION IN VITRO AND IN VIVO by SAHI, Jasminder, STERN, Ralph H, LECLUYSE, Edward L, MILAD, Mark A, ROSE, Kelly A, GIBSON, Gordon, XIANXIAN ZHENG, STILGENBAUER, Linda, SADAGOPAN, Nalini, JOLLEY, Summer, GILBERT, Darryl

“…Avasimibe, an acyl-CoA:cholesterol acyltransferase inhibitor, has been previously shown to be a potent inducer of CYP3A4 and multiple drug resistance protein…”
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Alternatives to the ROC Curve AUC and C-statistic for Risk Prediction Models by Stern, Ralph H

“…Assessment of risk prediction models has primarily utilized measures of discrimination, the ROC curve AUC and C-statistic. These derive from the risk…”
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Characterization of a Novel Human MUTYH Variant Causing Colonic Polyposis through Disruption of the Fe-S Cluster by McDonnell, Kevin, Chemler, Joseph A., Marvin, Monica L., Stern, Ralph H., Raskin, Leon, Sherman, David H., Gruber, Stephen B.

“…Abstract only…”
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Tolerance to nicotinic acid flushing by Stern, R H, Spence, J D, Freeman, D J, Parbtani, A

“…The mechanism of tolerance to nicotinic acid flushing was determined in subjects during a 5-day course of treatment. Objective measures of skin blood flow were…”
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Atorvastatin Coadministration May Increase Digoxin Concentrations by Inhibition of Intestinal P-Glycoprotein-Mediated Secretion by Boyd, Rebecca A., Stern, Ralph H., Stewart, Barhra H., Wu, Xiaochun, Reyner, Eric L., Zegarac, Elizabeth A., Randinitis, Edward J., Whitfield, Lloyd

“…The effect of atorvastatin on digoxin pharmacokinetics was assessed in 24 healthy volunteers in two studies. Subjects received 0.25 mg digoxin daily for 20…”
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