Search Results - "Stern, P H"

Gα12/Gα13 Subunits of Heterotrimeric G Proteins Mediate Parathyroid Hormone Activation of Phospholipase D in UMR-106 Osteoblastic Cells by Singh, A. T. K, Gilchrist, A, Voyno-Yasenetskaya, T, Radeff-Huang, J. M, Stern, P. H

“…PTH, a major regulator of bone remodeling and a therapeutically effective bone anabolic agent, stimulates several signaling pathways in osteoblastic cells. Our…”
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Dose-dependent differential effects of risedronate on gene expression in osteoblasts by Wang, J., Stern, P.H.

“…Bisphosphonates have multiple effects on bone. Their actions on osteoclasts lead to inhibition of bone resorption, at least partially through apoptosis…”
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Elevated incidence of fractures in women with invasive breast cancer by Edwards, B. J., Gradishar, W. J., Smith, M. E., Pacheco, J. A., Holbrook, J., McKoy, J. M., Nardone, B., Tica, S., Godinez-Puig, V., Rademaker, A. W., Helenowski, I. B., Bunta, A. D., Stern, P. H., Rosen, S. T., West, D. P., Guise, T. A.

“…Summary This study evaluates the incidence of bone fractures in women with BC.We found that women with invasive breast cancer are at an increased risk for bone…”
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Cyclosporine A and FK506 induce osteoclast apoptosis in mouse bone marrow cell cultures by Igarashi, K, Hirotani, H, Woo, J.-T, Stern, P.H

“…Studies were carried out to characterize the effects of cyclosporines and FK506 on the formation and survival of osteoclasts deriving from mouse bone marrow…”
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Parathyroid hormonelike protein from human renal carcinoma cells: structural and functional homology with parathyroid hormone by STREWLER, G. J, STERN, P. H, JACOBS, J. W, EVELOFF, J, KLEIN, R. F, LEUNG, S. C, ROSENBLATT, M, NISSENSON, R. A

“…A variety of solid tumors secrete proteins that are immunochemically distinct from parathyroid hormone (PTH) but activate PTH-responsive adenylate cyclase…”
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Compactin Suppresses Bone Resorption by Inhibiting the Fusion of Prefusion Osteoclasts and Disrupting the Actin Ring in Osteoclasts by Woo, Je‐Tae, Kasai, Shinya, Stern, Paula H., Nagai, Kazuo

“…Compactin (mevastatin), which inhibits 3‐hydroxy‐3‐methylglutaryl–coenzyme A (HMG‐CoA) reductase, and thus biosynthesis of cholesterol and the prenylation of…”
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Bone anabolic responses to mechanical load in vitro involve COX-2 and constitutive NOS by Kunnel, J G, Igarashi, K, Gilbert, J L, Stern, P H

“…Mechanical stimulation is essential for maintaining the homeostasis and architecture of connective tissues including bone. The purpose of our study was to test…”
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Insulin‐Like Growth Factor I Production Is Essential for Anabolic Effects of Thyroid Hormone in Osteoblasts by Huang, Bill K., Golden, Laurence A., Tarjan, Gabor, Madison, Laird D., Stern, Paula H.

“…Thyroid hormone (T3) and insulin‐like growth factor I (IGF‐I) are critical regulators of skeletal function. T3 increases IGF‐I production in bone. To assess…”
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Antagonist minigenes identify genes regulated by parathyroid hormone through G protein-selective and G protein co-regulated mechanisms in osteoblastic cells by Wang, J., Gilchrist, A., Stern, P.H.

“…Parathyroid hormone (PTH) is the major hormone regulating bone remodeling. Binding of PTH to the PTH1 receptor (PTH1R), a heterotrimeric G protein coupled…”
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Parathyroid hormone stimulates translocation of protein kinase C isozymes in UMR-106 osteoblastic osteosarcoma cells by Dossing, D.A, Radeff, J.M, Sanders, J, Lee, S.-K, Hsieh, M.-R, Stern, P.H

“…Studies with antagonists have provided evidence that protein kinase C (PKC) is involved in several of the actions of parathyroid hormone (PTH) on bone. PTH…”
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Endothelin receptors, second messengers, and actions in bone by Stern, P H, Tatrai, A, Semler, D E, Lee, S K, Lakatos, P, Strieleman, P J, Tarjan, G, Sanders, J L

“…Endothelins are a class of peptides that are produced by and elicit responses in many tissues. A growing literature documents the presence and effects of…”
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Serum interleukin-6 and bone metabolism in patients with thyroid function disorders by LAKATOS, P, FOLDES, J, HORVATH, C, KISS, L, TATRAI, A, TAKACS, I, TARJAN, G, STERN, P. H

“…To determine the possible involvement of interleukin-6 (IL-6) in the bone loss of hyperthyroidism, relationships between thyroid status, biochemical and…”
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Expression and phorbol ester–induced down‐regulation of protein kinase C isozymes in osteoblasts by Sanders, Jennifer L., Stern, Paula H.

“…The protein kinase C (PKC) enzyme family consists of at least 11 isozymes in three classes, with characteristic tissue distributions. Phorbol esters activate…”
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Cadmium Accelerates Bone Loss in Ovariectomized Mice and Fetal Rat Limb Bones in Culture by Bhattacharyya, M. H., Whelton, B. D., Stern, P. H., Peterson, D. P.

“…Loss of bone mineral after ovariectomy was studied in mice exposed to dietary cadmium at 0.25, 5, or 50 ppm. Results show that dietary cadmium at 50 ppm…”
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Parathyroid hormone‐induced resorption in fetal rat limb bones is associated with production of the metalloproteinases collagenase and gelatinase B by Witty, Jean P., Foster, Shirley A., Stricklin, George P., Matrisian, Lynn M., Stern, Paula H.

“…The role of matrix metalloproteinases in parathyroid hormone (PTH)‐induced bone resorption was assayed using a fetal rat limb bone culture system. Cotreatment…”
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In vitro mechanical and cellular responses of neonatal mouse bones to loading using a novel micromechanical-testing device by Kunnel, J G, Gilbert, J L, Stern, P H

“…Mechanical stimulation is critical for the maintenance of bone architecture and bone mass. These effects are dependent on the magnitude, duration, and rate of…”
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Endothelin-1-evoked calcium transients in UMR-106 osteoblastic osteosarcoma cells are mediated through endothelin-A and endothelin-B receptors by Semler, D E, Ohlstein, E H, Nambi, P, Slater, C, Stern, P H

“…Endothelin (ET) receptor subtypes involved in the modulation of intracellular calcium were studied in UMR-106 osteoblastic osteosarcoma cells. Calcium…”
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In vivo-Like Drug Responses of Human Tumors Growing in Three-Dimensional Gel-Supported Primary Culture by Vescio, Robert A., Redfern, Charles H., Nelson, Theodora J., Ugoretz, Scott, Stern, Peter H., Hoffman, Robert M.

“…An in vitro test of cell sensitivity to drugs that indicates in vivo response is an important need in cancer therapy and cancer drug development. Toward this…”
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Endothelin-1 actions on resorption, collagen and noncollagen protein synthesis, and phosphatidylinositol turnover in bone organ cultures by Tatrai, A, Foster, S, Lakatos, P, Shankar, G, Stern, P H

“…The effects of endothelin-1 (ET) on several tissues are mediated by prostaglandins. In this study, we investigated the actions of ET on bone and determined…”
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Diurnal rhythms in Ca transfer into bone, Ca release from bone, and bone resorbing activity in serum of rats by Shinoda, H, Stern, P H

“…To characterize diurnal rhythms in calcium transfer in and out of bone, rats were adapted to a 12:12 h light-dark illumination program (with light from 0600 to…”
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