Search Results - "Stern, AS"

Molecular characterization of interleukin 12 by Podlaski, F J, Nanduri, V B, Hulmes, J D, Pan, Y C, Levin, W, Danho, W, Chizzonite, R, Gately, M K, Stern, A S

“…Interleukin 12 (IL-12), formerly known as cytotoxic lymphocyte maturation factor and natural killer cell stimulatory factor, is a cytokine secreted by a human…”
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Accelerated acquisition of high resolution triple-resonance spectra using non-uniform sampling and maximum entropy reconstruction by Rovnyak, David, Frueh, Dominique P., Sastry, Mallika, Sun, Zhen-Yu J., Stern, Alan S., Hoch, Jeffrey C., Wagner, Gerhard

“…Non-uniform sampling is shown to provide significant time savings in the acquisition of a suite of three-dimensional NMR experiments utilized for obtaining…”
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THE INTERLEUKIN-12/INTERLEUKIN-12-RECEPTOR SYSTEM: Role in Normal and Pathologic Immune Responses by Gately, Maurice K, Renzetti, Louis M, Magram, Jeanne, Stern, Alvin S, Adorini, Luciano, Gubler, Ueli, Presky, David H

“…Interleukin-12 (IL-12) is a heterodimeric cytokine that plays a central role in promoting type 1 T helper cell (Th1) responses and, hence, cell-mediated…”
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Modern Spectrum Analysis in Multidimensional NMR Spectroscopy:  Comparison of Linear-Prediction Extrapolation and Maximum-Entropy Reconstruction by Stern, Alan S, Li, Kuo-Bin, Hoch, Jeffrey C

“…NMR spectroscopy is an inherently insensitive technique, and many challenging applications such as biomolecular studies operate at the very limits of…”
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Resolution and sensitivity of high field nuclear magnetic resonance spectroscopy by Rovnyak, D, Hoch, J C, Stern, A S, Wagner, G

“…The arrival of very high field magnets and cryogenic circuitries, and the development of relaxation-optimized pulse sequences have added powerful tools for…”
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Maximum entropy reconstruction, spectrum analysis and deconvolution in multidimensional nuclear magnetic resonance by Hoch, J C, Stern, A S

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Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity by Ling, P, Gately, MK, Gubler, U, Stern, AS, Lin, P, Hollfelder, K, Su, C, Pan, YC, Hakimi, J

“…IL-12, a heterodimeric cytokine, consists of two disulfide-linked subunits, p40 and p35. We investigated the role of p40 in ligand binding and signal…”
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Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist by Gillessen, S, Carvajal, D, Ling, P, Podlaski, F J, Stremlo, D L, Familletti, P C, Gubler, U, Presky, D H, Stern, A S, Gately, M K

“…Interleukin-12 (IL-12) is a cytokine that has regulatory effects on T and natural killer (NK) cells and is composed of two disulfide-bonded subunits, p40 and…”
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New Carbon-Detected Protein NMR Experiments Using CryoProbes by Serber, Zach, Richter, Christian, Moskau, Detlef, Böhlen, Jean-Marc, Gerfin, Tobias, Marek, Daniel, Häberli, Markus, Baselgia, Ludivica, Laukien, Frank, Stern, Alan S, Hoch, Jeffrey C, Dötsch, Volker

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De novo Backbone and Sequence Design of an Idealized α/β-barrel Protein: Evidence of Stable Tertiary Structure by Offredi, F, Dubail, F, Kischel, P, Sarinski, K, Stern, A.S, Van de Weerdt, C, Hoch, J.C, Prosperi, C, François, J.M, Mayo, S.L, Martial, J.A

“…We have designed, synthesized, and characterized a 216 amino acid residue sequence encoding a putative idealized α/β-barrel protein. The design was elaborated…”
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Modeling physical health and functional health status: The role of combat exposure, posttraumatic stress disorder, and personal resource attributes by Taft, Casey T., Stern, Amy S., King, Lynda A., King, Daniel W.

“…This study examined associations of combat exposure and posttraumatic stress disorder (PTSD) with physical health conditions and also incorporated hardiness…”
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Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor) by Gately, MK, Desai, BB, Wolitzky, AG, Quinn, PM, Dwyer, CM, Podlaski, FJ, Familletti, PC, Sinigaglia, F, Chizonnite, R, Gubler, U

“…IL-12 is a heterodimeric cytokine that was identified on the basis of its ability to synergize with IL-2 in the induction of cytotoxic effector cells and was…”
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High-resolution aliphatic side-chain assignments in 3D HCcoNH experiments with joint H-C evolution and non-uniform sampling by Sun, Zhen-Yu J, Hyberts, Sven G, Rovnyak, David, Park, Sunghyouk, Stern, Alan S, Hoch, Jeffrey C, Wagner, Gerhard

“…We describe an efficient NMR triple resonance approach that correlates, at high resolution, protein side-chain and backbone resonances. It relies on the…”
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The Hidden Thermodynamics of a Zinc Finger by Lachenmann, Marcel J., Ladbury, John E., Phillips, Nelson B., Narayana, Narendra, Qian, Xiuqi, Weiss, Michael A.

“…The Zn finger provides a model for studies of protein structure and stability. Its core contains a conserved phenylalanine residue adjoining three…”
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Purification to Homogeneity and Partial Characterization of Cytotoxic Lymphocyte Maturation Factor From Human B-Lymphoblastoid Cells by Stern, Alvin S., Podlaski, Frank J., Hulmes, Jeffrey D., Pan, Yu-Ching E., Quinn, Phyllis M., Wokitzky, Aimee G., Familletti, Philip C., Stremlo, Donna L., Truitt, Terri, Chizzonite, Richard, Gately, Maurice K.

“…A cytokine that can synergize with interleukin 2 to activate cytotoxic lymphocytes was purified to homogeneity. The protein, provisionally called cytotoxic…”
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Multiple-quantum magic-angle spinning spectroscopy using nonlinear sampling by Rovnyak, David, Filip, Claudiu, Itin, Boris, Stern, Alan S., Wagner, Gerhard, Griffin, Robert G., Hoch, Jeffrey C.

“…NMR spectroscopy is a relatively insensitive technique and many biomolecular applications operate near the limits of sensitivity and resolution. A particularly…”
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Interleukin-12 an integral cytokine in the immune response by Stern, Alvin S., Magram, Jeanne, Presky, David H.

“…Interleukin 12 (IL-12) is a heterodimeric cytokine that is produced primarily by antigen - presenting cells and plays a primary role in the induction of…”
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Interleukin-12 antagonist activity of mouse interleukin-12 p40 homodimer in vitro and in vivo by Gately, M K, Carvajal, D M, Connaughton, S E, Gillessen, S, Warrier, R R, Kolinsky, K D, Wilkinson, V L, Dwyer, C M, Higgins, Jr, G F, Podlaski, F J, Faherty, D A, Familletti, P C, Stern, A S, Presky, D H

“…Mo(p40)2 is a potent IL-12 antagonist that interacts strongly with the beta 1 subunit of the IL-12R to block binding of moIL-12 to the high-affinity mouse…”
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Maximum Entropy and the Nearly Black Object by Donoho, David L., Johnstone, Iain M., Hoch, Jeffrey C., Stern, Alan S.

“…Maximum entropy (ME) inversion is a non-linear inversion technique for inverse problems where the object to be recovered is known to be positive. It has been…”
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Molecular Dynamics of the Long Neurotoxin LSIII by Connolly, Peter J, Stern, Alan S, Turner, Christopher J, Hoch, Jeffrey C

“…Long neurotoxins bind tightly and specifically to the nicotinic acetylcholine receptor (AChR) in postsynaptic membranes and are useful for exploring the…”
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