Search Results - "Sterckx, J"

Beyond the VSG layer: Exploring the role of intrinsic disorder in the invariant surface glycoproteins of African trypanosomes by Sülzen, Hagen, Volkov, Alexander N, Geens, Rob, Zahedifard, Farnaz, Stijlemans, Benoit, Zoltner, Martin, Magez, Stefan, Sterckx, Yann G-J, Zoll, Sebastian

“…In the bloodstream of mammalian hosts, African trypanosomes face the challenge of protecting their invariant surface receptors from immune detection. This…”
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Long-term hematopoietic stem cells trigger quiescence in Leishmania parasites by Dirkx, Laura, Van Acker, Sara I, Nicolaes, Yasmine, Cunha, João Luís Reis, Ahmad, Rokaya, Hendrickx, Rik, Caljon, Ben, Imamura, Hideo, Ebo, Didier G, Jeffares, Daniel C, Sterckx, Yann G-J, Maes, Louis, Hendrickx, Sarah, Caljon, Guy

“…Addressing the challenges of quiescence and post-treatment relapse is of utmost importance in the microbiology field. This study shows that Leishmania infantum…”
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Immunogenicity Risk Profile of Nanobodies by Ackaert, Chloé, Smiejkowska, Natalia, Xavier, Catarina, Sterckx, Yann G J, Denies, Sofie, Stijlemans, Benoit, Elkrim, Yvon, Devoogdt, Nick, Caveliers, Vicky, Lahoutte, Tony, Muyldermans, Serge, Breckpot, Karine, Keyaerts, Marleen

“…Nanobodies (Nbs), the variable domains of camelid heavy chain-only antibodies, are a promising class of therapeutics or imaging reagents entering the clinic…”
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Biophysical characterization of the Plasmodium falciparum circumsporozoite protein's N‐terminal domain by Geens, Rob, Stanisich, Jessica, Beyens, Olivier, D'Hondt, Stijn, Thiberge, Jean‐Michel, Ryckebosch, Amber, De Groot, Anke, Magez, Stefan, Vertommen, Didier, Amino, Rogerio, De Winter, Hans, Volkov, Alexander N., Tompa, Peter, Sterckx, Yann G.‐J.

“…The circumsporozoite protein (CSP) is the main surface antigen of the Plasmodium sporozoite (SPZ) and forms the basis of the currently only licensed…”
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Development of a Nanobody-based lateral flow assay to detect active Trypanosoma congolense infections by Pinto Torres, Joar E., Goossens, Julie, Ding, Jianzu, Li, Zeng, Lu, Shaohong, Vertommen, Didier, Naniima, Peter, Chen, Rui, Muyldermans, Serge, Sterckx, Yann G.-J., Magez, Stefan

“…Animal African trypanosomosis (AAT), a disease affecting livestock, is caused by parasites of the Trypanosoma genus (mainly T . vivax and T . congolense ). AAT…”
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Development of a recombinase polymerase amplification lateral flow assay for the detection of active Trypanosoma evansi infections by Li, Zeng, Pinto Torres, Joar Esteban, Goossens, Julie, Stijlemans, Benoit, Sterckx, Yann G-J, Magez, Stefan

“…Animal trypanosomosis caused by Trypanosoma evansi is known as "surra" and is a widespread neglected tropical disease affecting wild and domestic animals…”
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Retrospective in silico mutation profiling of SARS-CoV-2 structural proteins circulating in Uganda by July 2021: Towards refinement of COVID-19 disease vaccines, diagnostics, and therapeutics by Odongo, Steven, Okella, Hedmon, Ndekezi, Christian, Okee, Moses, Namayanja, Monica, Mujuni, Brian, Sterckx, Yann G J, Kizito, Dennison, Radwanska, Magdalena, Magez, Stefan, Ikwap, Kokas, Mwiine, Frank Nobert, Lutwama, Julius Julian, Ibingira, Charles

“…The SARS-CoV-2 virus, the agent of COVID-19, caused unprecedented loss of lives and economic decline worldwide. Although the introduction of public health…”
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Structural basis for osmotic regulation of the DNA binding properties of H-NS proteins by Qin, Liang, Bdira, Fredj Ben, Sterckx, Yann G J, Volkov, Alexander N, Vreede, Jocelyne, Giachin, Gabriele, van Schaik, Peter, Ubbink, Marcellus, Dame, Remus T

“…H-NS proteins act as osmotic sensors translating changes in osmolarity into altered DNA binding properties, thus, regulating enterobacterial genome…”
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Identification of Nanobodies against the Acute Myeloid Leukemia Marker CD33 by Romão, Ema, Krasniqi, Ahmet, Maes, Laila, Vandenbrande, Camille, Sterckx, Yann G-J, Stijlemans, Benoit, Vincke, Cécile, Devoogdt, Nick, Muyldermans, Serge

“…Nanobodies (Nbs) are the smallest antigen-binding, single domain fragments derived from heavy-chain-only antibodies from Camelidae. Among the several…”
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Tendon and fascial structure contributions to knee muscle excursions and knee joint displacement by Snoeck, O, Beyer, B, Feipel, V, Salvia, P, Sterckx, J.-L, Rooze, M, Van Sint Jan, S

“…Abstract Background Semitendinosus and gracilis muscles whose tendons are used in surgical reconstruction of the anterior cruciate ligament maintain their…”
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Structural basis for the high specificity of a Trypanosoma congolense immunoassay targeting glycosomal aldolase by Pinto, Joar, Odongo, Steven, Lee, Felicity, Gaspariunaite, Vaiva, Muyldermans, Serge, Magez, Stefan, Sterckx, Yann G-J

“…Animal African trypanosomosis (AAT) is a neglected tropical disease which imposes a heavy burden on the livestock industry in Sub-Saharan Africa. Its causative…”
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Genomic and Phenotypic Characterization of Experimentally Selected Resistant Leishmania donovani Reveals a Role for Dynamin-1-Like Protein in the Mechanism of Resistance to a Novel Antileishmanial Compound by Hefnawy, Aya, Negreira, Gabriel, Jara, Marlene, Cotton, James A, Maes, Ilse, D'Haenens, Erika, Imamura, Hideo, Cuypers, Bart, Monsieurs, Pieter, Mouchtoglou, Christina, De Winter, Hans, Pintelon, Isabel, Timmermans, Jean-Pierre, Berriman, Matt, Sanders, Mandy, Martin, Julio, de Muylder, Geraldine, Dujardin, Jean-Claude, Sterckx, Yann G-J, Domagalska, Malgorzata Anna

“…The implementation of prospective drug resistance (DR) studies in the research-and-development (R&D) pipeline is a common practice for many infectious diseases…”
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Mass spectrometry-complemented molecular modeling predicts the interaction interface for a camelid single-domain antibody targeting the Plasmodium falciparum circumsporozoite protein’s C-terminal domain by Opuni, Kwabena F.M., Ruß, Manuela, Geens, Rob, Vocht, Line De, Wielendaele, Pieter Van, Debuy, Christophe, Sterckx, Yann G.-J., Glocker, Michael O.

“…Bioanalytical methods that enable rapid and high-detail characterization of binding specificities and strengths of protein complexes with low sample…”
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An Anti-proteome Nanobody Library Approach Yields a Specific Immunoassay for Trypanosoma congolense Diagnosis Targeting Glycosomal Aldolase by Odongo, Steven, Sterckx, Yann G J, Stijlemans, Benoît, Pillay, Davita, Baltz, Théo, Muyldermans, Serge, Magez, Stefan

“…Infectious diseases pose a severe worldwide threat to human and livestock health. While early diagnosis could enable prompt preventive interventions, the…”
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Chromosomal meiotic segregation, embryonic developmental kinetics and DNA (hydroxy)methylation analysis consolidate the safety of human oocyte vitrification by De Munck, N, Petrussa, L, Verheyen, G, Staessen, C, Vandeskelde, Y, Sterckx, J, Bocken, G, Jacobs, K, Stoop, D, De Rycke, M, Van de Velde, H

“…Oocyte vitrification has been introduced into clinical settings without extensive pre-clinical safety testing. In this study, we analysed major safety aspects…”
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A high-throughput target-based screening approach for the identification and assessment of Mycobacterium tuberculosis mycothione reductase inhibitors by Smiejkowska, Natalia, Oorts, Lauren, Van Calster, Kevin, De Vooght, Linda, Geens, Rob, Mattelaer, Henri-Philippe, Augustyns, Koen, Strelkov, Sergei V, Lamprecht, Dirk, Temmerman, Koen, Sterckx, Yann G-J, Cappoen, Davie, Cos, Paul

“…The World Health Organization's goal to combat tuberculosis (TB) is hindered by the emergence of anti-microbial resistance, therefore necessitating the…”
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Structural Basis for the Specific Neutralization of Stx2a with a Camelid Single Domain Antibody Fragment by Bernedo-Navarro, Robert Alvin, Romão, Ema, Yano, Tomomasa, Pinto, Joar, De Greve, Henri, Sterckx, Yann G-J, Muyldermans, Serge

“…Shiga toxin-producing (STEC) are a subset of pathogens leading to illnesses such as diarrhea, hemolytic uremic syndrome and even death. The Shiga toxins are…”
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Experimental Strategies to Explore Drug Action and Resistance in Kinetoplastid Parasites by Van den Kerkhof, Magali, Sterckx, Yann, Leprohon, Philippe, Maes, Louis, Caljon, Guy

“…Kinetoplastids are the causative agents of leishmaniasis, human African trypanosomiasis, and American trypanosomiasis. They are responsible for high mortality…”
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A Fijivirus Major Viroplasm Protein Shows RNA-Stimulated ATPase Activity by Adopting Pentameric and Hexameric Assemblies of Dimers by Llauger, Gabriela, Melero, Roberto, Monti, Demián, Sycz, Gabriela, Huck-Iriart, Cristián, Cerutti, María L, Klinke, Sebastián, Mikkelsen, Evelyn, Tijman, Ariel, Arranz, Rocío, Alfonso, Victoria, Arellano, Sofía M, Goldbaum, Fernando A, Sterckx, Yann G J, Carazo, José-María, Kaufman, Sergio B, Dans, Pablo D, Del Vas, Mariana, Otero, Lisandro H

“…Fijiviruses replicate and package their genomes within viroplasms in a process involving RNA-RNA and RNA-protein interactions. Here, we demonstrate that the 24…”
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The History of Anti-Trypanosome Vaccine Development Shows That Highly Immunogenic and Exposed Pathogen-Derived Antigens Are Not Necessarily Good Target Candidates: Enolase and ISG75 as Examples by Magez, Stefan, Li, Zeng, Nguyen, Hang Thi Thu, Pinto Torres, Joar Esteban, Van Wielendaele, Pieter, Radwanska, Magdalena, Began, Jakub, Zoll, Sebastian, Sterckx, Yann G.-J.

“…Salivarian trypanosomes comprise a group of extracellular anthroponotic and zoonotic parasites. The only sustainable method for global control of these…”
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