The impact of standard chemotherapy on miRNA signature in plasma in AML patients

Highlights • We examined paired plasma samples in AML patients at diagnosis and in remission. • All patients received standard chemotherapy and were examined before transplantation. • A specific 6 miRNA signature significantly sensitive to chemotherapy was found. • The abundance of these miRNAs was...

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Bibliographic Details
Published in:	Leukemia research Vol. 39; no. 12; pp. 1389 - 1395
Main Authors:	Koutova, Linda, Sterbova, Monika, Pazourkova, Eva, Pospisilova, Sarka, Svobodova, Iveta, Horinek, Ales, Lysak, Daniel, Korabecna, Marie
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-12-2015
Subjects:	Acute myeloid leukemia Adult Antineoplastic Combined Chemotherapy Protocols - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Consolidation Chemotherapy Cytarabine - administration & dosage Female Gene Expression Regulation, Leukemic - drug effects Hematology, Oncology and Palliative Medicine Humans Idarubicin - administration & dosage Leukemia, Myeloid, Acute - blood Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - genetics Liquid biopsy Male MicroRNAs - biosynthesis MicroRNAs - blood MicroRNAs - genetics Middle Aged miRNA signature Mitoxantrone - administration & dosage Pilot Projects Plasma Real-Time Polymerase Chain Reaction Remission Remission Induction RNA, Neoplasm - biosynthesis RNA, Neoplasm - blood RNA, Neoplasm - genetics Standard chemotherapy Transcriptome miRNA signature Plasma Liquid biopsy Remission Acute myeloid leukemia Standard chemotherapy
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Summary:	Highlights • We examined paired plasma samples in AML patients at diagnosis and in remission. • All patients received standard chemotherapy and were examined before transplantation. • A specific 6 miRNA signature significantly sensitive to chemotherapy was found. • The abundance of these miRNAs was elevated in plasma at diagnosis and decreased after chemotherapy. • All 6 miRNAs were not or weakly present in plasma of healthy individuals.
ISSN:	0145-2126 1873-5835
DOI:	10.1016/j.leukres.2015.08.009