Search Results - "Sterba, Martin"

Oxidative stress, redox signaling, and metal chelation in anthracycline cardiotoxicity and pharmacological cardioprotection by Stěrba, Martin, Popelová, Olga, Vávrová, Anna, Jirkovský, Eduard, Kovaříková, Petra, Geršl, Vladimír, Simůnek, Tomáš

“…Anthracyclines (doxorubicin, daunorubicin, or epirubicin) rank among the most effective anticancer drugs, but their clinical usefulness is hampered by the risk…”
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Comprehensive review of cardiovascular toxicity of drugs and related agents by Mladěnka, Přemysl, Applová, Lenka, Patočka, Jiří, Costa, Vera Marisa, Remiao, Fernando, Pourová, Jana, Mladěnka, Aleš, Karlíčková, Jana, Jahodář, Luděk, Vopršalová, Marie, Varner, Kurt J., Štěrba, Martin

“…Cardiovascular diseases are a leading cause of morbidity and mortality in most developed countries of the world. Pharmaceuticals, illicit drugs, and toxins can…”
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Structure–Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase IIβ Interactions by Jirkovská, Anna, Karabanovich, Galina, Kubeš, Jan, Skalická, Veronika, Melnikova, Iuliia, Korábečný, Jan, Kučera, Tomáš, Jirkovský, Eduard, Nováková, Lucie, Bavlovič Piskáčková, Hana, Škoda, Josef, Štěrba, Martin, Austin, Caroline A, Šimůnek, Tomáš, Roh, Jaroslav

“…Cardioprotective activity of dexrazoxane (ICRF-187), the only clinically approved drug against anthracycline-induced cardiotoxicity, has traditionally been…”
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Development of water-soluble prodrugs of the bisdioxopiperazine topoisomerase IIβ inhibitor ICRF-193 as potential cardioprotective agents against anthracycline cardiotoxicity by Bavlovič Piskáčková, Hana, Jansová, Hana, Kubeš, Jan, Karabanovich, Galina, Váňová, Nela, Kollárová-Brázdová, Petra, Melnikova, Iuliia, Jirkovská, Anna, Lenčová-Popelová, Olga, Chládek, Jaroslav, Roh, Jaroslav, Šimůnek, Tomáš, Štěrba, Martin, Štěrbová-Kovaříková, Petra

“…The bisdioxopiperazine topoisomerase IIβ inhibitor ICRF-193 has been previously identified as a more potent analog of dexrazoxane (ICRF-187), a drug used in…”
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Clinically Translatable Prevention of Anthracycline Cardiotoxicity by Dexrazoxane Is Mediated by Topoisomerase II Beta and Not Metal Chelation by Jirkovský, Eduard, Jirkovská, Anna, Bavlovič-Piskáčková, Hana, Skalická, Veronika, Pokorná, Zuzana, Karabanovich, Galina, Kollárová-Brázdová, Petra, Kubeš, Jan, Lenčová-Popelová, Olga, Mazurová, Yvona, Adamcová, Michaela, Lyon, Alexander R., Roh, Jaroslav, Šimůnek, Tomáš, Štěrbová-Kovaříková, Petra, Štěrba, Martin

“…Anthracycline-induced heart failure has been traditionally attributed to direct iron-catalyzed oxidative damage. Dexrazoxane (DEX)-the only drug approved for…”
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Exploring the effects of topoisomerase II inhibitor XK469 on anthracycline cardiotoxicity and DNA damage by Keresteš, Veronika, Kubeš, Jan, Applová, Lenka, Kollárová, Petra, Lenčová-Popelová, Olga, Melnikova, Iuliia, Karabanovich, Galina, Khazeem, Mushtaq M, Piskáčková, Hana Bavlovič, Štěrbová-Kovaříková, Petra, Austin, Caroline A, Roh, Jaroslav, Štěrba, Martin, Šimůnek, Tomáš, Jirkovská, Anna

“…Anthracyclines, such as doxorubicin (adriamycin), daunorubicin, or epirubicin, rank among the most effective agents in classical anticancer chemotherapy…”
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Molecular remodeling of left and right ventricular myocardium in chronic anthracycline cardiotoxicity and post-treatment follow up by Lenco, Juraj, Lencová-Popelová, Olga, Å imůnek, Tomás, Gersl, Vladimír, Jirkovský, Eduard, Mazurová, Yvona, Adamcová, Michaela, Å tÄrba, Martin

“…Chronic anthracycline cardiotoxicity is a serious clinical issue with well characterized functional and histopathological hallmarks. However, molecular…”
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Characterization of a new model of chemotherapy-induced heart failure with reduced ejection fraction and nephrotic syndrome in Ren-2 transgenic rats by Gawrys, Olga, Jíchová, Šárka, Miklovič, Matúš, Husková, Zuzana, Kikerlová, Soňa, Sadowski, Janusz, Kollárová, Petra, Lenčová-Popelova, Olga, Hošková, Lenka, Imig, John D., Mazurova, Yvona, Kolář, František, Melenovský, Vojtěch, Štěrba, Martin, Červenka, Luděk

“…All anthracyclines, including doxorubicin (DOXO), the most common and still indispensable drug, exhibit cardiotoxicity with inherent risk of irreversible…”
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Targeted treatment of severe vascular malformations harboring PIK3CA and TEK mutations with alpelisib is highly effective with limited toxicity by Sterba, Martin, Pokorna, Petra, Faberova, Renata, Pinkova, Blanka, Skotakova, Jarmila, Seehofnerova, Anna, Blatny, Jan, Janigova, Lucia, Koskova, Olga, Palova, Hana, Mahdal, Michal, Pazourek, Lukas, Jabandziev, Petr, Slaby, Ondrej, Mudry, Peter, Sterba, Jaroslav

“…This was a prospective cohort study of eighteen patients with large and debilitating vascular malformations with one or more major systemic complications. In…”
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Catalytic inhibitors of topoisomerase II differently modulate the toxicity of anthracyclines in cardiac and cancer cells by Vavrova, Anna, Jansova, Hana, Mackova, Eliska, Machacek, Miloslav, Haskova, Pavlina, Tichotova, Lucie, Sterba, Martin, Simunek, Tomas

“…Anthracyclines (such as doxorubicin or daunorubicin) are among the most effective anticancer drugs, but their usefulness is hampered by the risk of…”
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Prodrug of ICRF-193 provides promising protective effects against chronic anthracycline cardiotoxicity in a rabbit model in vivo by Kollárová-Brázdová, Petra, Lenčová-Popelová, Olga, Karabanovich, Galina, Kocúrová-Lengvarská, Júlia, Kubeš, Jan, Váňová, Nela, Mazurová, Yvona, Adamcová, Michaela, Jirkovská, Anna, Holečková, Magdalena, Šimůnek, Tomáš, Štěrbová-Kovaříková, Petra, Roh, Jaroslav, Štěrba, Martin

“…The anthracycline (ANT) anticancer drugs such as doxorubicin or daunorubicin (DAU) can cause serious myocardial injury and chronic cardiac dysfunction in…”
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Investigation of Structure-Activity Relationships of Dexrazoxane Analogs Reveals Topoisomerase II β Interaction as a Prerequisite for Effective Protection against Anthracycline Cardiotoxicity by Kollárová-Brázdová, Petra, Jirkovská, Anna, Karabanovich, Galina, Pokorná, Zuzana, Bavlovič Piskáčková, Hana, Jirkovský, Eduard, Kubeš, Jan, Lenčová-Popelová, Olga, Mazurová, Yvona, Adamcová, Michaela, Skalická, Veronika, Štěrbová-Kovaříková, Petra, Roh, Jaroslav, Šimůnek, Tomáš, Štěrba, Martin

“…Bisdioxopiperazine agent dexrazoxane (ICRF-187) has been the only effective and approved drug for prevention of chronic anthracycline cardiotoxicity. However,…”
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Primary prevention of chronic anthracycline cardiotoxicity with ACE inhibitor is temporarily effective in rabbits, but benefits wane in post-treatment follow-up by Pokorná, Zuzana, Kollárová-Brázdová, Petra, Lenčová-Popelová, Olga, Jirkovský, Eduard, Kubeš, Jan, Mazurová, Yvona, Adamcová, Michaela, Holečková, Magdalena, Palička, Vladimír, Šimůnek, Tomáš, Štěrba, Martin

“…Angiotensin-converting enzyme inhibitors (ACEis) have been used to treat anthracycline (ANT)-induced cardiac dysfunction, and they appear beneficial for…”
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Cardiac miRNA expression during the development of chronic anthracycline-induced cardiomyopathy using an experimental rabbit model by Adamcova, Michaela, Parova, Helena, Lencova-Popelova, Olga, Kollarova-Brazdova, Petra, Baranova, Ivana, Slavickova, Marcela, Stverakova, Tereza, Mikyskova, Petra Sauer, Mazurova, Yvona, Sterba, Martin

“…Anthracycline cardiotoxicity is a well-known complication of cancer treatment, and miRNAs have emerged as a key driver in the pathogenesis of cardiovascular…”
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Proteomic insights into chronic anthracycline cardiotoxicity by Štěrba, Martin, Popelová, Olga, Lenčo, Juraj, Fučíková, Alena, Brčáková, Eva, Mazurová, Yvona, Jirkovský, Eduard, Šimůnek, Tomáš, Adamcová, Michaela, Mičuda, Stanislav, Stulík, Jiří, Geršl, Vladimír

“…Abstract Chronic anthracycline cardiotoxicity is a feared complication of cancer chemotherapy. However, despite several decades of primarily hypothesis-driven…”
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Development of a Rat Model of Intra-Amniotic Inflammation via Ultrasound-Guided Administration of a Triggering Agent in the Gestational Sac to Enable Analysis of Individual Amniotic Fluid Samples by Stranik, Jaroslav, Kacerovsky, Marian, Sterba, Martin, Andrys, Ctirad, Abad, Cilia, Staud, Frantisek, Micuda, Stanislav, Soucek, Ondrej, Jacobsson, Bo, Musilova, Ivana

“…To develop a rat model of intra-amniotic inflammation, characterized by the concentration of interleukin-6 in the amniotic fluid, induced by an…”
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A Cyclic Pentamethinium Salt Induces Cancer Cell Cytotoxicity through Mitochondrial Disintegration and Metabolic Collapse by Krejcir, Radovan, Krcova, Lucie, Zatloukalova, Pavlina, Briza, Tomas, Coates, Philip J, Sterba, Martin, Muller, Petr, Kralova, Jarmila, Martasek, Pavel, Kral, Vladimir, Vojtesek, Borivoj

“…Cancer cells preferentially utilize glycolysis for ATP production even in aerobic conditions (the Warburg effect) and adapt mitochondrial processes to their…”
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Cardioprotective effects of inorganic nitrate/nitrite in chronic anthracycline cardiotoxicity: Comparison with dexrazoxane by Lenčová-Popelová, Olga, Jirkovský, Eduard, Jansová, Hana, Jirkovská-Vávrová, Anna, Vostatková-Tichotová, Lucie, Mazurová, Yvona, Adamcová, Michaela, Chládek, Jaroslav, Hroch, Miloš, Pokorná, Zuzana, Geršl, Vladimír, Šimůnek, Tomáš, Štěrba, Martin

“…Abstract Dexrazoxane (DEX) is a clinically available cardioprotectant that reduces the toxicity induced by anthracycline (ANT) anticancer drugs; however, DEX…”
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Chronic anthracycline cardiotoxicity: molecular and functional analysis with focus on nuclear factor erythroid 2-related factor 2 and mitochondrial biogenesis pathways by Jirkovsky, Eduard, Popelová, Olga, Kriváková-Stanková, Pavla, Vávrová, Anna, Hroch, Milos, Hasková, Pavlína, Brcáková-Dolezelová, Eva, Micuda, Stanislav, Adamcová, Michaela, Simůnek, Tomás, Cervinková, Zuzana, Gersl, Vladimír, Sterba, Martin

“…Anthracycline anticancer drugs (e.g., doxorubicin or daunorubicin) can induce chronic cardiotoxicity and heart failure (HF), both of which are believed to be…”
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Proteomic investigation of embryonic rat heart-derived H9c2 cell line sheds new light on the molecular phenotype of the popular cell model by Lenčo, Juraj, Lenčová-Popelová, Olga, Link, Marek, Jirkovská, Anna, Tambor, Vojtěch, Potůčková, Eliška, Stulík, Jiří, Šimůnek, Tomáš, Štěrba, Martin

“…Due to their cardiac origin, H9c2 cells rank among the most popular cell lines in current cardiovascular research, yet molecular phenotype remains elusive…”
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