Search Results - "Stepien, Karolina P"

Munc18-1 is crucial to overcome the inhibition of synaptic vesicle fusion by αSNAP by Stepien, Karolina P., Prinslow, Eric A., Rizo, Josep

“…Munc18-1 and Munc13-1 orchestrate assembly of the SNARE complex formed by syntaxin-1, SNAP-25 and synaptobrevin, allowing exquisite regulation of…”
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Multiple factors maintain assembled trans-SNARE complexes in the presence of NSF and αSNAP by Prinslow, Eric A, Stepien, Karolina P, Pan, Yun-Zu, Xu, Junjie, Rizo, Josep

“…Neurotransmitter release requires formation of trans-SNARE complexes between the synaptic vesicle and plasma membranes, which likely underlies synaptic vesicle…”
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Open syntaxin overcomes exocytosis defects of diverse mutants in C. elegans by Tien, Chi-Wei, Yu, Bin, Huang, Mengjia, Stepien, Karolina P., Sugita, Kyoko, Xie, Xiaoyu, Han, Liping, Monnier, Philippe P., Zhen, Mei, Rizo, Josep, Gao, Shangbang, Sugita, Shuzo

“…Assembly of SNARE complexes that mediate neurotransmitter release requires opening of a ‘closed’ conformation of UNC-64/syntaxin. Rescue of unc-13/Munc13…”
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Molecular machinery turns full circle by Rizo, Josep, Jaczynska, Klaudia, Stepien, Karolina P

“…Two proteins called Sec17 and Sec18 may have a larger role in membrane fusion than is commonly assumed in textbook models…”
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Synaptotagmin-1–, Munc18-1–, and Munc13-1–dependent liposome fusion with a few neuronal SNAREs by Stepien, Karolina P., Rizo, Josep

“…Neurotransmitter release is governed by eight central proteins among other factors: the neuronal SNAREs syntaxin-1, synaptobrevin, and SNAP-25, which form a…”
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Re‐examining how Munc13‐1 facilitates opening of syntaxin‐1 by Magdziarek, Magdalena, Bolembach, Agnieszka A., Stepien, Karolina P., Quade, Bradley, Liu, Xiaoxia, Rizo, Josep

“…Munc13‐1 is crucial for neurotransmitter release and, together with Munc18‐1, orchestrates assembly of the neuronal SNARE complex formed by syntaxin‐1,…”
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SNARE assembly enlightened by cryo-EM structures of a synaptobrevin-Munc18-1-syntaxin-1 complex by Stepien, Karolina P, Xu, Junjie, Zhang, Xuewu, Bai, Xiao-Chen, Rizo, Josep

“…Munc18-1 forms a template to organize assembly of the neuronal SNARE complex that triggers neurotransmitter release, binding first to a closed conformation of…”
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Structural and mechanistic insights into secretagogin-mediated exocytosis by Qin, Jiao, Liu, Qi, Liu, Zhe, Pan, Yun-Zu, Sifuentes-Dominguez, Luis, Stepien, Karolina P., Wang, Yan, Tu, Yingfeng, Tan, Shuai, Wang, Yuan, Sun, Qingxiang, Mo, Xianming, Rizo, Josep, Burstein, Ezra, Jia, Da

“…Secretagogin (SCGN) is a hexa–EF-hand protein that is highly expressed in the pancreas, brain, and gastrointestinal tract. SCGN is known to modulate regulated…”
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