Search Results - "Stephenson, Natalie L"

Cancer-Associated Protein Kinase C Mutations Reveal Kinase’s Role as Tumor Suppressor by Antal, Corina E., Hudson, Andrew M., Kang, Emily, Zanca, Ciro, Wirth, Christopher, Stephenson, Natalie L., Trotter, Eleanor W., Gallegos, Lisa L., Miller, Crispin J., Furnari, Frank B., Hunter, Tony, Brognard, John, Newton, Alexandra C.

“…Protein kinase C (PKC) isozymes have remained elusive cancer targets despite the unambiguous tumor promoting function of their potent ligands, phorbol esters,…”
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Direct observation of proteolytic cleavage at the S2 site upon forced unfolding of the Notch negative regulatory region by Stephenson, Natalie L., Avis, Johanna M.

“…The conserved Notch signaling pathway plays crucial roles in developing and self-renewing tissues. Notch is activated upon ligand-induced conformation change…”
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Mixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors by Marusiak, Anna A., Edwards, Zoe C., Hugo, Willy, Trotter, Eleanor W., Girotti, Maria R., Stephenson, Natalie L., Kong, Xiangju, Gartside, Michael G., Fawdar, Shameem, Hudson, Andrew, Breitwieser, Wolfgang, Hayward, Nicholas K., Marais, Richard, Lo, Roger S., Brognard, John

“…RAF inhibitor therapy yields significant reductions in tumour burden in the majority of V600E-positive melanoma patients; however, resistance occurs within…”
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Targeted genetic dependency screen facilitates identification of actionable mutations in FGFR4, MAP3K9, and PAK5 in lung cancer by Fawdar, Shameem, Trotter, Eleanor W., Li, Yaoyong, Stephenson, Natalie L., Hanke, Franziska, Marusiak, Anna A., Edwards, Zoe C., Ientile, Sara, Waszkowycz, Bohdan, Miller, Crispin J., Brognard, John

“…Approximately 70% of patients with non–small-cell lung cancer present with late-stage disease and have limited treatment options, so there is a pressing need…”
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Using large-scale genomics data to identify driver mutations in lung cancer: methods and challenges by Hudson, Andrew M, Wirth, Christopher, Stephenson, Natalie L, Fawdar, Shameem, Brognard, John, Miller, Crispin J

“…Lung cancer is the commonest cause of cancer death in the world and carries a poor prognosis for most patients. While precision targeting of mutated proteins…”
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Somatically mutated ABL1 is an actionable and essential NSCLC survival gene by Testoni, Ewelina, Stephenson, Natalie L, Torres‐Ayuso, Pedro, Marusiak, Anna A, Trotter, Eleanor W, Hudson, Andrew, Hodgkinson, Cassandra L, Morrow, Christopher J, Dive, Caroline, Brognard, John

“…The lack of actionable mutations in patients with non‐small cell lung cancer (NSCLC) presents a significant hurdle in the design of targeted therapies for this…”
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Improved Production and Biophysical Analysis of Recombinant Silicatein-α by Sparkes, Emily I, Kettles, Rachel A, Egedeuzu, Chisom S, Stephenson, Natalie L, Caslin, Stephanie A, Tabatabaei Dakhili, S Yasin, Wong, Lu Shin

“…Silicatein-α is a hydrolase found in siliceous sea sponges with a unique ability to condense and hydrolyse silicon-oxygen bonds. The enzyme is thus of interest…”
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Mutational analysis of the Notch2 negative regulatory region identifies key structural elements for mechanical stability by Stephenson, Natalie L., Avis, Johanna M.

“…•Mutations within heterodimerization (HD) domain of Notch2 reduce mechanical stability.•Structural changes are observed within the LNRA:B linker region/LNRB…”
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Protein kinase Cα gain-of-function variant in Alzheimer’s disease displays enhanced catalysis by a mechanism that evades down-regulation by Callender, Julia A., Yang, Yimin, Lordén, Gema, Stephenson, Natalie L., Jones, Alexander C., Brognard, John, Newton, Alexandra C.

“…Conventional protein kinase C (PKC) family members are reversibly activated by binding to the second messengers Ca2+ and diacylglycerol, events that break…”
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Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis by Marusiak, Anna A, Stephenson, Natalie L, Baik, Hayeon, Trotter, Eleanor W, Li, Yaoyong, Blyth, Karen, Mason, Susan, Chapman, Phil, Puto, Lorena A, Read, Jon A, Brassington, Claire, Pollard, Hannah K, Phillips, Chris, Green, Isabelle, Overman, Ross, Collier, Matthew, Testoni, Ewelina, Miller, Crispin J, Hunter, Tony, Sansom, Owen J, Brognard, John

“…MLK4 is a member of the mixed-lineage family of kinases that regulate the JNK, p38, and ERK kinase signaling pathways. MLK4 mutations have been identified in…”
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Truncation- and motif-based pan-cancer analysis reveals tumor-suppressing kinases by Hudson, Andrew M, Stephenson, Natalie L, Li, Cynthia, Trotter, Eleanor, Fletcher, Adam J, Katona, Gitta, Bieniasz-Krzywiec, Patrycja, Howell, Matthew, Wirth, Chris, Furney, Simon, Miller, Crispin J, Brognard, John

“…A major challenge in cancer genomics is identifying "driver" mutations from the many neutral "passenger" mutations within a given tumor. To identify driver…”
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Abstract 4408: Mutant ABL1 is a genetic dependency in non-small cell lung cancer amenable to pharmacological intervention by Torres-Ayuso, PEDRO, Testoni, Ewelina, Stephenson, Natalie L., Marusiak, Anna A., Trotter, Eleanor W., Hudson, Andrew, Hodgkinson, Cassandra L., Morrow, Christopher J., Dive, Caroline, Brognard, John

“…Abstract Non-small cell lung cancer (NSCLC) is the most frequent lung cancer subtype and it affects near 1.5 million patients worldwide annually. The lack of…”
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Protein kinase Ca gain-of-function variant in Alzheimer’s disease displays enhanced catalysis by a mechanism that evades down-regulation by Callender, Julia A, Yang, Yimin, Lordén, Gema, Stephenson, Natalie L, Jones, Alexander C, Brognard, John, Newton, Alexandra C

“…Conventional protein kinase C (PKC) family members are reversibly activated by binding to the second messengers Ca2+ and diacylglycerol, events that break…”
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Abstract 5270: Prevalence of inactivating protein kinase C mutations in human cancers by Antal, Corina E., Kang, Emily, Stephenson, Natalie L., Trotter, Eleanor W., Hunter, Tony, Brognard, John, Newton, Alexandra

“…Abstract Protein kinase C (PKC) levels are aberrant in diverse cancers and over 400 mutations in PKC have been identified in human cancers. Here we…”
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Abstract 125: Protein kinase C loss-of-function mutations in cancer reveal role as tumor suppressor by Antal, Corina E., Hudson, Andrew M., Kang, Emily, Zanca, Ciro, Wirth, Christopher, Stephenson, Natalie L., Trotter, Eleanor W., Gallegos, Lisa L., Miller, Crispin, Furnari, Frank, Hunter, Tony, Brognard, John, Newton, Alexandra C.

“…Abstract Protein kinase C (PKC) remains an elusive chemotherapeutic target despite decades of research. To determine whether PKC isozymes function as oncogenes…”
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Somatically mutated ABL 1 is an actionable and essential NSCLC survival gene by Testoni, Ewelina, Stephenson, Natalie L, Torres‐Ayuso, Pedro, Marusiak, Anna A, Trotter, Eleanor W, Hudson, Andrew, Hodgkinson, Cassandra L, Morrow, Christopher J, Dive, Caroline, Brognard, John

“…Abstract The lack of actionable mutations in patients with non‐small cell lung cancer ( NSCLC ) presents a significant hurdle in the design of targeted…”
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