Search Results - "Stephens, R. L"

Intergenerational effects of racism on amygdala and hippocampus resting state functional connectivity by Kral, T. R. A., Williams, C. Y., Wylie, A. C., McLaughlin, K., Stephens, R. L., Mills-Koonce, W. R., Birn, R. M., Propper, C. B., Short, S. J.

“…Racism is an insidious problem with far-reaching effects on the lives of Black, Indigenous, and People of Color (BIPOC). The pervasive negative impact of…”
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Author Correction: Intergenerational effects of racism on amygdala and hippocampus resting state functional connectivity by Kral, T. R. A., Williams, C. Y., Wylie, A. C., McLaughlin, K., Stephens, R. L., Mills‑Koonce, W. R., Birn, R. M., Propper, C. B., Short, S. J.

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PI3K signalling in inflammation by Hawkins, P.T., Stephens, L.R.

“…PI3Ks regulate several key events in the inflammatory response to damage and infection. There are four Class I PI3K isoforms (PI3Kα,β,γ,δ), three Class II PI3K…”
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Antioxidants attenuate multiple phases of formalin-induced nociceptive response in mice by Hacimuftuoglu, A., Handy, C.R., Goettl, V.M., Lin, C.G., Dane, S., Stephens, R.L.

“…An emerging theme in the study of the pathophysiology of chronic and persistent pain is the role of pro-oxidant substances. Reactive oxygen species (ROS) have…”
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Quantitative Assessment and Characterization of Visceral Hyperalgesia Evoked by Esophageal Balloon Distention and Acid Perfusion in Patients With Functional Heartburn, Nonerosive Reflux Disease, and Erosive Esophagitis by Yang, Min, Li, Zhao-shen, Chen, Dong-feng, Zou, Duo-wu, Xu, Xiao-rong, Fang, Dian-chun, Xu, Guo-ming, Stephens, R.L, Wang, Zheng-guo

“…BACKGROUND AND OBJECTIVESThe role of esophageal hypersensitivity in functional heartburn (FH) with negative pH test, negative symptom index, and the proton…”
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GLT-1 overexpression attenuates bladder nociception and local/cross-organ sensitization of bladder nociception by Yang, M, Roman, K, Chen, D-F, Wang, Z-G, Lin, Y, Stephens, Jr, R L

“…Glutamatergic pathways mediate transmission of pain. Strategies to reduce glutamatergic neurotransmission may have beneficial effects to mitigate nociception…”
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Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B by Stokoe, David, Stephens, Leonard R., Copeland, Terry, Piers R. J. Gaffney, Reese, Colin B., Painter, Gavin F., Holmes, Andrew B., McCormick, Frank, Hawkins, Phillip T.

“…Protein kinase B (PKB) is a proto-oncogene that is activated in signaling pathways initiated by phosphoinositide 3-kinase. Chromatographic separation of brain…”
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Signalling through Class I PI3Ks in mammalian cells by Hawkins, P T, Anderson, K E, Davidson, K, Stephens, L R

“…It is now accepted that activation of Class I PI3Ks (phosphoinositide 3-kinases) is one of the most important signal transduction pathways used by cell-surface…”
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Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: a new intracellular signalling system? by Stephens, L R, Jackson, T R, Hawkins, P T

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FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments by Ridley, S H, Ktistakis, N, Davidson, K, Anderson, K E, Manifava, M, Ellson, C D, Lipp, P, Bootman, M, Coadwell, J, Nazarian, A, Erdjument-Bromage, H, Tempst, P, Cooper, M A, Thuring, J W, Lim, Z Y, Holmes, A B, Stephens, L R, Hawkins, P T

“…FENS-1 and DFCP1 are recently discovered proteins containing one or two FYVE-domains respectively. We show that the FYVE domains in these proteins can bind…”
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Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils by Stephens, L. R, Hughes, K. T, Irvine, R. F

“…Neutrophils activated by the formyl peptide f-Met-Leu-Phe transiently accumulate a small subset of highly polar inositol lipids. A similar family of lipids…”
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Phosphatidylinositol 3-phosphate is generated in phagosomal membranes by Ellson, C.D., Anderson, K.E., Morgan, G., Chilvers, E.R., Lipp, P., Stephens, L.R., Hawkins, P.T.

“…Phagocytic cells such as neutrophils and macrophages engulf and destroy invading microorganisms. After internalization, material captured within the phagosomal…”
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Glutamate Transporter GLT-1 Upregulation Attenuates Visceral Nociception and Hyperalgesia via Spinal Mechanisms Not Related to Anti-Inflammatory or Probiotic Effects by Lin, Y., Roman, K., Foust, K. D., Kaspar, B. K., Bailey, M. T., Stephens, R. L.

“…Visceral pain is the most common reason for physician visits in US. Glutamate is the major excitatory neurotransmitter and mediates visceral nociceptive…”
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PYY and NPY: control of gastric motility via action on Y1 and Y2 receptors in the DVC by Chen, C.‐H., Stephens Jr, R. L., Rogers, R. C.

“…The pancreatic polypeptide family of hormones and neurotransmitters including pancreatic polypeptide (PP), peptide YY (PYY) and neuropeptide Y (NPY) are…”
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Platelet-derived growth factor stimulates synthesis of Ptdlns(3,4,5)P3 by activating a Ptdlns(4,5)P2 3-OH kinase by Hawkins, P. T., Jackson, T. R., Stephens, L. R.

“…ALTHOUGH the hormone-stimulated synthesis of 3-phosphorylated inositol lipids is known to form an intracellular signalling system1–5, there is no consensus on…”
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Stepwise phosphorylation of myo -inositol leading to myo -inositol hexakisphosphate in Dictyostelium by Stephens, L. R, Irvine, R. F

“…Although myo-inositol hexakisphosphate (InsP6; phytate) is the most abundant inositol phosphate in nature and probably has a wide variety of functions, neither…”
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Receptor specificity of growth factor-stimulated synthesis of 3-phosphorylated inositol lipids in Swiss 3T3 cells by JACKSON, T. R, STEPHENS, L. R, HAWKINS, P. T

“…We have investigated synthesis of 3-phosphorylated inositol lipids in growth factor-stimulated Swiss 3T3 cells. Those growth factors tested which act via…”
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Structure determination of a tetrasaccharide: transient nuclear Overhauser effects in the rotating frame by Bothner-By, Aksel A, Stephens, R. L, Lee, Jumee, Warren, Christopher D, Jeanloz, R. W

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Granulocyte macrophage‐colony stimulating factor stimulates both association and activation of phosphoinositide 3OH‐kinase and src‐related tyrosine kinase(s) in human myeloid derived cells by Corey, S., Eguinoa, A., Puyana‐Theall, K., Bolen, J.B., Cantley, L., Mollinedo, F., Jackson, T.R., Hawkins, P.T., Stephens, L.R.

“…The signalling pathways used by the GM‐CSF receptor are currently unknown. Here we show that in human myeloid derived cells GM‐CSF can stimulate; (i) the…”
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Phase II trial of mitotane and cisplatin in patients with adrenal carcinoma: a Southwest Oncology Group study by Bukowski, R M, Wolfe, M, Levine, H S, Crawford, D E, Stephens, R L, Gaynor, E, Harker, W G

“…Previous reports of chemotherapy in patients with adrenal cancer have described responses to cisplatin (CDDP). Because of these reports of good results, a…”
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