Search Results - "Stephen L. Hoffman"

Antibody Feedback Limits the Expansion of B Cell Responses to Malaria Vaccination but Drives Diversification of the Humoral Response by McNamara, Hayley A., Idris, Azza H., Sutton, Henry J., Vistein, Rachel, Flynn, Barbara J., Cai, Yeping, Wiehe, Kevin, Lyke, Kirsten E., Chatterjee, Deepyan, KC, Natasha, Chakravarty, Sumana, Lee Sim, B. Kim, Hoffman, Stephen L., Bonsignori, Mattia, Seder, Robert A., Cockburn, Ian A.

“…Generating sufficient antibody to block infection is a key challenge for vaccines against malaria. Here, we show that antibody titers to a key target, the…”
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Atypical B cells are part of an alternative lineage of B cells that participates in responses to vaccination and infection in humans by Sutton, Henry J., Aye, Racheal, Idris, Azza H., Vistein, Rachel, Nduati, Eunice, Kai, Oscar, Mwacharo, Jedida, Li, Xi, Gao, Xin, Andrews, T. Daniel, Koutsakos, Marios, Nguyen, Thi H.O., Nekrasov, Maxim, Milburn, Peter, Eltahla, Auda, Berry, Andrea A., KC, Natasha, Chakravarty, Sumana, Sim, B. Kim Lee, Wheatley, Adam K., Kent, Stephen J., Hoffman, Stephen L., Lyke, Kirsten E., Bejon, Philip, Luciani, Fabio, Kedzierska, Katherine, Seder, Robert A., Ndungu, Francis M., Cockburn, Ian A.

“…The diversity of circulating human B cells is unknown. We use single-cell RNA sequencing (RNA-seq) to examine the diversity of both antigen-specific and total…”
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Knockout of Anopheles stephensi immune gene LRIM1 by CRISPR-Cas9 reveals its unexpected role in reproduction and vector competence by Inbar, Ehud, Eappen, Abraham G, Alford, Robert T, Reid, William, Harrell, Robert A, Hosseini, Maryam, Chakravarty, Sumana, Li, Tao, Sim, B Kim Lee, Billingsley, Peter F, Hoffman, Stephen L

“…PfSPZ Vaccine against malaria is composed of Plasmodium falciparum (Pf) sporozoites (SPZ) manufactured using aseptically reared Anopheles stephensi mosquitoes…”
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A Microscale Human Liver Platform that Supports the Hepatic Stages of Plasmodium falciparum and vivax by March, Sandra, Ng, Shengyong, Velmurugan, Soundarapandian, Galstian, Ani, Shan, Jing, Logan, David J., Carpenter, Anne E., Thomas, David, Sim, B. Kim Lee, Mota, Maria M., Hoffman, Stephen L., Bhatia, Sangeeta N.

“…The Plasmodium liver stage is an attractive target for the development of antimalarial drugs and vaccines, as it provides an opportunity to interrupt the life…”
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Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue by Adjalley, Sophie H., Johnston, Geoffrey L., Li, Tao, Eastman, Richard T., Ekland, Eric H., Eappen, Abraham G., Richman, Adam, Sim, B. Kim Lee, Lee, Marcus C. S., Hoffman, Stephen L., Fidock, David A.

“…Clinical studies and mathematical models predict that, to achieve malaria elimination, combination therapies will need to incorporate drugs that block the…”
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Machine learning prediction of malaria vaccine efficacy based on antibody profiles by Wistuba-Hamprecht, Jacqueline, Reuter, Bernhard, Fendel, Rolf, Hoffman, Stephen L, Campo, Joseph J, Felgner, Philip L, Kremsner, Peter G, Mordmüller, Benjamin, Pfeifer, Nico

“…Immunization through repeated direct venous inoculation of Plasmodium falciparum (Pf) sporozoites (PfSPZ) under chloroquine chemoprophylaxis, using the PfSPZ…”
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PfSPZ-CVac efficacy against malaria increases from 0% to 75% when administered in the absence of erythrocyte stage parasitemia: A randomized, placebo-controlled trial with controlled human malaria infection by Murphy, Sean C, Deye, Gregory A, Sim, B. Kim Lee, Galbiati, Shirley, Kennedy, Jessie K, Cohen, Kristen W, Chakravarty, Sumana, K. C., Natasha, Abebe, Yonas, James, Eric R, Kublin, James G, Hoffman, Stephen L, Richie, Thomas L, Jackson, Lisa A

“…PfSPZ-CVac combines ‘PfSPZ Challenge’, which consists of infectious Plasmodium falciparum sporozoites (PfSPZ), with concurrent antimalarial chemoprophylaxis…”
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Controlled human malaria infection with Plasmodium falciparum demonstrates impact of naturally acquired immunity on virulence gene expression by Bachmann, Anna, Bruske, Ellen, Krumkamp, Ralf, Turner, Louise, Wichers, J Stephan, Petter, Michaela, Held, Jana, Duffy, Michael F, Sim, B Kim Lee, Hoffman, Stephen L, Kremsner, Peter G, Lell, Bertrand, Lavstsen, Thomas, Frank, Matthias, Mordmüller, Benjamin, Tannich, Egbert

“…The pathogenesis of Plasmodium falciparum malaria is linked to the variant surface antigen PfEMP1, which mediates tethering of infected erythrocytes to the…”
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A replication competent Plasmodium falciparum parasite completely attenuated by dual gene deletion by Goswami, Debashree, Patel, Hardik, Betz, William, Armstrong, Janna, Camargo, Nelly, Patil, Asha, Chakravarty, Sumana, Murphy, Sean C, Sim, B Kim Lee, Vaughan, Ashley M, Hoffman, Stephen L, Kappe, Stefan HI

“…Vaccination with infectious Plasmodium falciparum (Pf) sporozoites (SPZ) administered with antimalarial drugs (PfSPZ-CVac), confers superior sterilizing…”
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DSM265 for Plasmodium falciparum chemoprophylaxis: a randomised, double blinded, phase 1 trial with controlled human malaria infection by Sulyok, Mihály, Dr, Rückle, Thomas, PhD, Roth, Alexandra, PhD, Mürbeth, Raymund E, MD, Chalon, Stephan, PhD, Kerr, Nicola, BA(Mod), Samec, Sonia Schnieper, PhD, Gobeau, Nathalie, PhD, Calle, Carlos Lamsfus, MSc, Ibáñez, Javier, MSc, Sulyok, Zita, MD, Held, Jana, PhD, Gebru, Tamirat, MSc, Granados, Patricia, MSc, Brückner, Sina, PhD, Nguetse, Christian, PhD, Mengue, Juliana, MSc, Lalremruata, Albert, MSc, Sim, Kim Lee, PhD, Hoffman, Stephen L, MD, Möhrle, Jörg J, PhD, Kremsner, Peter G, Prof, Mordmüller, Benjamin, MD

“…Summary Background A drug for causal (ie, pre-erythrocytic) prophylaxis of Plasmodium falciparum malaria with prolonged activity would substantially advance…”
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Plasmodium falciparum 7G8 challenge provides conservative prediction of efficacy of PfNF54-based PfSPZ Vaccine in Africa by Silva, Joana C., Dwivedi, Ankit, Moser, Kara A., Sissoko, Mahamadou S., Epstein, Judith E., Healy, Sara A., Lyke, Kirsten E., Mordmüller, Benjamin, Kremsner, Peter G., Duffy, Patrick E., Murshedkar, Tooba, Sim, B. Kim Lee, Richie, Thomas L., Hoffman, Stephen L.

“…Controlled human malaria infection (CHMI) has supported Plasmodium falciparum (Pf) malaria vaccine development by providing preliminary estimates of vaccine…”
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Cryopreservation of Anopheles stephensi embryos by James, Eric R., Wen, Yingda, Overby, James, Pluchino, Kristen, McTighe, Shane, Matheny, Stephen, Eappen, Abraham, Hoffman, Stephen L., Billingsley, Peter F.

“…The ability to cryopreserve mosquitoes would revolutionize work on these vectors of major human infectious diseases by conserving stocks, new isolates,…”
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Repeat controlled human Plasmodium falciparum infections delay bloodstream patency and reduce symptoms by Ferrer, Patricia, Berry, Andrea A., Bucsan, Allison N., Prajapati, Surendra K., Krishnan, Karthik, Barbeau, Michelle C., Rickert, David M., Guerrero, Sandra Mendoza, Usui, Miho, Abebe, Yonas, Patil, Asha, Chakravarty, Sumana, Billingsley, Peter F., Pa’ahana-Brown, Faith, Strauss, Kathy, Shrestha, Biraj, Nomicos, Effie, Deye, Gregory A., Sim, B. Kim Lee, Hoffman, Stephen L., Williamson, Kim C., Lyke, Kirsten E.

“…Resistance to clinical malaria takes years to develop even in hyperendemic regions and sterilizing immunity has rarely been observed. To evaluate the…”
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Ultra-low volume intradermal administration of radiation-attenuated sporozoites with the glycolipid adjuvant 7DW8-5 completely protects mice against malaria by Watson, Felicia N., Shears, Melanie J., Kalata, Anya C., Duncombe, Caroline J., Seilie, A. Mariko, Chavtur, Chris, Conrad, Ethan, Cruz Talavera, Irene, Raappana, Andrew, Sather, D. Noah, Chakravarty, Sumana, Sim, B. Kim Lee, Hoffman, Stephen L., Tsuji, Moriya, Murphy, Sean C.

“…Radiation-attenuated sporozoite (RAS) vaccines can completely prevent blood stage Plasmodium infection by inducing liver-resident memory CD8 + T cells to…”
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Controlled Human Malaria Infection Leads to Long-Lasting Changes in Innate and Innate-like Lymphocyte Populations by Mpina, Maxmillian, Maurice, Nicholas J, Yajima, Masanao, Slichter, Chloe K, Miller, Hannah W, Dutta, Mukta, McElrath, M Juliana, Stuart, Kenneth D, De Rosa, Stephen C, McNevin, John P, Linsley, Peter S, Abdulla, Salim, Tanner, Marcel, Hoffman, Stephen L, Gottardo, Raphael, Daubenberger, Claudia A, Prlic, Martin

“…Animal model studies highlight the role of innate-like lymphocyte populations in the early inflammatory response and subsequent parasite control following…”
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The Potential Role of Vaccines in the Elimination of Falciparum Malaria and the Eventual Eradication of Malaria by Plowe, Christopher V., Alonso, Pedro, Hoffman, Stephen L.

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Clonal selection drives protective memory B cell responses in controlled human malaria infection by Murugan, Rajagopal, Buchauer, Lisa, Triller, Gianna, Kreschel, Cornelia, Costa, Giulia, Pidelaserra Martí, Gemma, Imkeller, Katharina, Busse, Christian E, Chakravarty, Sumana, Sim, B Kim Lee, Hoffman, Stephen L, Levashina, Elena A, Kremsner, Peter G, Mordmüller, Benjamin, Höfer, Thomas, Wardemann, Hedda

“…Affinity maturation, the clonal selection and expansion of antigen-activated B cells expressing somatically mutated antibody variants that develop during T…”
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Controlled human malaria infections by intradermal injection of cryopreserved Plasmodium falciparum sporozoites by Roestenberg, Meta, Bijker, Else M, Sim, B Kim Lee, Billingsley, Peter F, James, Eric R, Bastiaens, Guido J H, Teirlinck, Anne C, Scholzen, Anja, Teelen, Karina, Arens, Theo, van der Ven, André J A M, Gunasekera, Anusha, Chakravarty, Sumana, Velmurugan, Soundarapandian, Hermsen, Cornelus C, Sauerwein, Robert W, Hoffman, Stephen L

“…Controlled human malaria infection with sporozoites is a standardized and powerful tool for evaluation of malaria vaccine and drug efficacy but so far only…”
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Discovery of Novel Plasmodium falciparum Pre-Erythrocytic Antigens for Vaccine Development by Aguiar, Joao C, Bolton, Jessica, Wanga, Joyce, Sacci, John B, Iriko, Hideyuki, Mazeika, Julie K, Han, Eun-Taek, Limbach, Keith, Patterson, Noelle B, Sedegah, Martha, Cruz, Ann-Marie, Tsuboi, Takafumi, Hoffman, Stephen L, Carucci, Daniel, Hollingdale, Michael R, Villasante, Eileen D, Richie, Thomas L

“…Nearly 100% protection against malaria infection can be achieved in humans by immunization with P. falciparum radiation-attenuated sporozoites (RAS). Although…”
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The Dantu blood group prevents parasite growth in vivo : Evidence from a controlled human malaria infection study by Kariuki, Silvia N, Macharia, Alexander W, Makale, Johnstone, Nyamu, Wilfred, Hoffman, Stephen L, Kapulu, Melissa C, Bejon, Philip, Rayner, Julian C, Williams, Thomas N

“…The long co-evolution of and has resulted in the selection of numerous human genetic variants that confer an advantage against severe malaria and death. One…”
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