Search Results - "Stephen Clark"

Spatial disparities in access to NHS dentistry: a neighbourhood-level analysis in England by Clark, Stephen D

“…Abstract Over the past decade, access to National Health Service (NHS) dentistry in England has been problematic. There are increasing media reports of…”
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Single-cell epigenomics: powerful new methods for understanding gene regulation and cell identity by Clark, Stephen J, Lee, Heather J, Smallwood, Sébastien A, Kelsey, Gavin, Reik, Wolf

“…Emerging single-cell epigenomic methods are being developed with the exciting potential to transform our knowledge of gene regulation. Here we review available…”
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Antibiotic resistance among invasive Neisseria meningitidis isolates in England, Wales and Northern Ireland (2010/11 to 2018/19) by Willerton, Laura, Lucidarme, Jay, Walker, Andrew, Lekshmi, Aiswarya, Clark, Stephen A, Walsh, Lloyd, Bai, Xilian, Lee-Jones, Lisa, Borrow, Ray

“…Invasive meningococcal disease (IMD), caused by Neisseria meningitidis, can have a fatality rate as high as 10%, even with appropriate treatment. In the UK,…”
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scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells by Clark, Stephen J., Argelaguet, Ricard, Kapourani, Chantriolnt-Andreas, Stubbs, Thomas M., Lee, Heather J., Alda-Catalinas, Celia, Krueger, Felix, Sanguinetti, Guido, Kelsey, Gavin, Marioni, John C., Stegle, Oliver, Reik, Wolf

“…Parallel single-cell sequencing protocols represent powerful methods for investigating regulatory relationships, including epigenome-transcriptome…”
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Screening for Lung Cancer With Low-Dose Computed Tomography: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force by Jonas, Daniel E, Reuland, Daniel S, Reddy, Shivani M, Nagle, Max, Clark, Stephen D, Weber, Rachel Palmieri, Enyioha, Chineme, Malo, Teri L, Brenner, Alison T, Armstrong, Charli, Coker-Schwimmer, Manny, Middleton, Jennifer Cook, Voisin, Christiane, Harris, Russell P

“…IMPORTANCE: Lung cancer is the leading cause of cancer-related death in the US. OBJECTIVE: To review the evidence on screening for lung cancer with low-dose…”
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Energy Current Rectification and Mobility Edges by Balachandran, Vinitha, Clark, Stephen R, Goold, John, Poletti, Dario

“…We investigate how the presence of a single-particle mobility edge in a system can generate strong energy current rectification. Specifically, we study a…”
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Genome-wide base-resolution mapping of DNA methylation in single cells using single-cell bisulfite sequencing (scBS-seq) by Clark, Stephen J, Smallwood, Sébastien A, Lee, Heather J, Krueger, Felix, Reik, Wolf, Kelsey, Gavin

“…Single-cell bisulfite sequencing (scBS-seq) is a cost-effective method for surveying CpG methylation across genomes of single cells. It gives higher coverage…”
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Multi-omics profiling of mouse gastrulation at single-cell resolution by Argelaguet, Ricard, Clark, Stephen J., Mohammed, Hisham, Stapel, L. Carine, Krueger, Christel, Kapourani, Chantriolnt-Andreas, Imaz-Rosshandler, Ivan, Lohoff, Tim, Xiang, Yunlong, Hanna, Courtney W., Smallwood, Sebastien, Ibarra-Soria, Ximena, Buettner, Florian, Sanguinetti, Guido, Xie, Wei, Krueger, Felix, Göttgens, Berthold, Rugg-Gunn, Peter J., Kelsey, Gavin, Dean, Wendy, Nichols, Jennifer, Stegle, Oliver, Marioni, John C., Reik, Wolf

“…Formation of the three primary germ layers during gastrulation is an essential step in the establishment of the vertebrate body plan and is associated with…”
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Parallel single-cell sequencing links transcriptional and epigenetic heterogeneity by Angermueller, Christof, Clark, Stephen J, Lee, Heather J, Macaulay, Iain C, Teng, Mabel J, Hu, Tim Xiaoming, Krueger, Felix, Smallwood, Sébastien A, Ponting, Chris P, Voet, Thierry, Kelsey, Gavin, Stegle, Oliver, Reik, Wolf

“…Parallel, genome-wide methylation and transcriptional profiling from a single cell (scM&T-seq) enables the discovery of associations between transcriptional…”
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Total Synthesis of (−)-Nakadomarin A by Clark, J. Stephen, Xu, Chao

“…A highly efficient 12‐step synthesis of the marine alkaloid (−)‐nakadomarin A has been accomplished. The key advanced intermediate, a tetracyclic ketone…”
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Tensor-Network Method to Simulate Strongly Interacting Quantum Thermal Machines by Brenes, Marlon, Mendoza-Arenas, Juan José, Purkayastha, Archak, Mitchison, Mark T., Clark, Stephen R., Goold, John

“…We present a methodology to simulate the quantum thermodynamics of thermal machines which are built from an interacting working medium in contact with…”
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Infective endocarditis in intravenous drug users in Europe: A clean start? by Chilvers, Nick, Clark, Stephen C.

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Continuous Histone Replacement by Hira Is Essential for Normal Transcriptional Regulation and De Novo DNA Methylation during Mouse Oogenesis by Nashun, Buhe, Hill, Peter W.S., Smallwood, Sebastien A., Dharmalingam, Gopuraja, Amouroux, Rachel, Clark, Stephen J., Sharma, Vineet, Ndjetehe, Elodie, Pelczar, Pawel, Festenstein, Richard J., Kelsey, Gavin, Hajkova, Petra

“…The integrity of chromatin, which provides a dynamic template for all DNA-related processes in eukaryotes, is maintained through replication-dependent and…”
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Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells by Hernando-Herraez, Irene, Evano, Brendan, Stubbs, Thomas, Commere, Pierre-Henri, Jan Bonder, Marc, Clark, Stephen, Andrews, Simon, Tajbakhsh, Shahragim, Reik, Wolf

“…Age-related tissue alterations have been associated with a decline in stem cell number and function. Although increased cell-to-cell variability in…”
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First Real-world Evidence of Meningococcal Group B Vaccine, 4CMenB, Protection Against Meningococcal Group W Disease: Prospective Enhanced National Surveillance, England by Ladhani, Shamez N, Campbell, Helen, Andrews, Nick, Parikh, Sydel R, White, Joanne, Edelstein, Michael, Clark, Stephen A, Lucidarme, Jay, Borrow, Ray, Ramsay, Mary E

“…Abstract Background 4CMenB is a protein-based meningococcal B vaccine, but the vaccine antigens may be present on non–group B meningococci. In September 2015,…”
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Just 2% of SARS-CoV-2—positive individuals carry 90% of the virus circulating in communities by Yang, Qing, Saldi, Tassa K., Gonzales, Patrick K., Lasda, Erika, Decker, Carolyn J., Tat, Kimngan L., Fink, Morgan R., Hager, Cole R., Davis, Jack C., Ozeroff, Christopher D., Muhlrad, Denise, Clark, Stephen K., Fattor, Will T., Meyerson, Nicholas R., Paige, Camille L., Gilchrist, Alison R., Barbachano-Guerrero, Arturo, Worden-Sapper, Emma R., Wu, Sharon S., Brisson, Gloria R., McQueen, Matthew B., Dowell, Robin D., Leinwand, Leslie, Parker, Roy, Sawyer, Sara L.

“…We analyze data from the fall 2020 pandemic response efforts at the University of Colorado Boulder, where more than 72,500 saliva samples were tested for…”
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Liquified petroleum gas provides a technically viable and financially feasible means to reduce Eskom's diesel cost burden by 30% to 40 by Clark, Stephen R, McGregor, Craig

“…In early 2022, we analysed the benefits of switching the fuel for the Ankerlig peaking plant from diesel to LPG (liquified petroleum gas or 'bottled' gas) to…”
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Assessment of Lung Cancer Screening Program Websites by Clark, Stephen D, Reuland, Daniel S, Enyioha, Chineme, Jonas, Daniel E

“…The US Preventive Services Task Force recommends that individuals at high risk for lung cancer consider benefits and harms before pursuing lung cancer…”
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Bilateral versus Single Internal-Thoracic-Artery Grafts at 10 Years by Taggart, David P, Benedetto, Umberto, Gerry, Stephen, Altman, Douglas G, Gray, Alastair M, Lees, Belinda, Gaudino, Mario, Zamvar, Vipin, Bochenek, Andrzej, Buxton, Brian, Choong, Cliff, Clark, Stephen, Deja, Marek, Desai, Jatin, Hasan, Ragheb, Jasinski, Marek, O’Keefe, Peter, Moraes, Fernando, Pepper, John, Seevanayagam, Siven, Sudarshan, Catherine, Trivedi, Uday, Wos, Stanislaw, Puskas, John, Flather, Marcus

“…In a randomized trial, 3102 patients undergoing CABG were assigned to receive bilateral or single internal-thoracic-artery grafts. There was no significant…”
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Beyond the usual suspects: Reviewing infections caused by typically-commensal Neisseria species by Walsh, Lloyd, Clark, Stephen A, Derrick, Jeremy P, Borrow, Ray

“…Few data outside of individual case reports are available on non-meningococcal, non-gonococcal species of Neisseria as causative agents of invasive disease…”
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