Search Results - "Stephen B. Kritchevsky"

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study by Justice, Jamie N., Nambiar, Anoop M., Tchkonia, Tamar, LeBrasseur, Nathan K., Pascual, Rodolfo, Hashmi, Shahrukh K., Prata, Larissa, Masternak, Michal M., Kritchevsky, Stephen B., Musi, Nicolas, Kirkland, James L.

“…Cellular senescence is a key mechanism that drives age-related diseases, but has yet to be targeted therapeutically in humans. Idiopathic pulmonary fibrosis…”
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The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates by Studenski, Stephanie A, Peters, Katherine W, Alley, Dawn E, Cawthon, Peggy M, McLean, Robert R, Harris, Tamara B, Ferrucci, Luigi, Guralnik, Jack M, Fragala, Maren S, Kenny, Anne M, Kiel, Douglas P, Kritchevsky, Stephen B, Shardell, Michelle D, Dam, Thuy-Tien L, Vassileva, Maria T

“…Low muscle mass and weakness are common and potentially disabling in older adults, but in order to become recognized as a clinical condition, criteria for…”
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Intentional weight loss and all-cause mortality: a meta-analysis of randomized clinical trials by Kritchevsky, Stephen B, Beavers, Kristen M, Miller, Michael E, Shea, M Kyla, Houston, Denise K, Kitzman, Dalane W, Nicklas, Barbara J

“…Obesity is associated with increased mortality, and weight loss trials show rapid improvement in many mortality risk factors. Yet, observational studies…”
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Geriatric assessment predicts survival for older adults receiving induction chemotherapy for acute myelogenous leukemia by Klepin, Heidi D., Geiger, Ann M., Tooze, Janet A., Kritchevsky, Stephen B., Williamson, Jeff D., Pardee, Timothy S., Ellis, Leslie R., Powell, Bayard L.

“…We investigated the predictive value of geriatric assessment (GA) on overall survival (OS) for older adults with acute myelogenous leukemia (AML). Consecutive…”
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Testing the Geroscience Hypothesis: Early Days by Kritchevsky, Stephen B, Justice, Jamie N

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Body Composition Remodeling and Mortality: The Health Aging and Body Composition Study by Santanasto, Adam J, Goodpaster, Bret H, Kritchevsky, Stephen B, Miljkovic, Iva, Satterfield, Suzanne, Schwartz, Ann V, Cummings, Steven R, Boudreau, Robert M, Harris, Tamara B, Newman, Anne B

“…Age-related losses of lean mass and shifts to central adiposity are related to functional decline and may predict mortality and/or explain part of the risk of…”
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Protein Intake and Mobility Limitation in Community‐Dwelling Older Adults: the Health ABC Study by Houston, Denise K., Tooze, Janet A., Garcia, Katelyn, Visser, Marjolein, Rubin, Susan, Harris, Tamara B., Newman, Anne B., Kritchevsky, Stephen B.

“…Objectives The current Recommended Dietary Allowance (RDA) for protein is based on short‐term nitrogen balance studies in young adults and may underestimate…”
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Frailty and risk for heart failure in older adults: The health, aging, and body composition study by Khan, Hassan, MD, MPhil, Kalogeropoulos, Andreas P., MD, PhD, Georgiopoulou, Vasiliki V., MD, Newman, Anne B., MD, MPH, Harris, Tamara B., MD, MS, Rodondi, Nicolas, MD, Bauer, Douglas C., MD, Kritchevsky, Stephen B., PhD, Butler, Javed, MD, MPH

“…Objective The aim of this study was to assess the association between frailty and risk for heart failure (HF) in older adults. Background Frailty is common in…”
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Putting epigenetic biomarkers to the test for clinical trials by Justice, Jamie N, Kritchevsky, Stephen B

“…Reliable biomarkers are needed to test the effectiveness of interventions intended to improve health and extend lifespan…”
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A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup by Justice, Jamie N., Ferrucci, Luigi, Newman, Anne B., Aroda, Vanita R., Bahnson, Judy L., Divers, Jasmin, Espeland, Mark A., Marcovina, Santica, Pollak, Michael N., Kritchevsky, Stephen B., Barzilai, Nir, Kuchel, George A.

“…Recent advances indicate that biological aging is a potentially modifiable driver of late-life function and chronic disease and have led to the development of…”
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Lipoteichoic acid from the cell wall of a heat killed Lactobacillus paracasei D3-5 ameliorates aging-related leaky gut, inflammation and improves physical and cognitive functions: from C. elegans to mice by Wang, Shaohua, Ahmadi, Shokouh, Nagpal, Ravinder, Jain, Shalini, Mishra, Sidharth P., Kavanagh, Kylie, Zhu, Xuewei, Wang, Zhan, McClain, Donald A., Kritchevsky, Stephen B., Kitzman, Dalane W., Yadav, Hariom

“…Increased inflammation associated with leaky gut is a major risk factor for morbidity and mortality in older adults; however, successful preventive and…”
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Effects of physical activity on strength and skeletal muscle fat infiltration in older adults: a randomized controlled trial by Goodpaster, Bret H, Chomentowski, Peter, Ward, Bryan K, Rossi, Andrea, Glynn, Nancy W, Delmonico, Matthew J, Kritchevsky, Stephen B, Pahor, Marco, Newman, Anne B

“…1 Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania; 2 Department of Health and Physical Activity, University of Pittsburgh,…”
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Associations between body composition and gait-speed decline: results from the Health, Aging, and Body Composition study by Beavers, Kristen M, Beavers, Daniel P, Houston, Denise K, Harris, Tamara B, Hue, Trisha F, Koster, Annemarie, Newman, Anne B, Simonsick, Eleanor M, Studenski, Stephanie A, Nicklas, Barbara J, Kritchevsky, Stephen B

“…Background: In older adults, every 0.1-m/s slower gait speed is associated with a 12% higher mortality. However, little research has identified risk factors…”
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Poor Appetite and Dietary Intake in Community‐Dwelling Older Adults by Meij, Barbara S., Wijnhoven, Hanneke A. H., Lee, Jung S., Houston, Denise K., Hue, Trisha, Harris, Tamara B., Kritchevsky, Stephen B., Newman, Anne B., Visser, Marjolein

“…Background/objectives Poor appetite in older adults leads to sub‐optimal food intake and increases the risk of undernutrition. The impact of poor appetite on…”
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Added Value of Physical Performance Measures in Predicting Adverse Health-Related Events: Results from the Health, Aging and Body Composition Study by Cesari, Matteo, Kritchevsky, Stephen B., Newman, Anne B., Simonsick, Eleanor M., Harris, Tamara B., Penninx, Brenda W., Brach, Jennifer S., Tylavsky, Frances A., Satterfield, Suzanne, Bauer, Doug C., Rubin, Susan M., Visser, Marjolein, Pahor, Marco

“…OBJECTIVES: To determine how three different physical performance measures (PPMs) combine for added utility in predicting adverse health events in elders…”
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Comparison of Handgrip and Leg Extension Strength in Predicting Slow Gait Speed in Older Adults by Fragala, Maren S., Alley, Dawn E., Shardell, Michelle D., Harris, Tamara B., McLean, Robert R., Kiel, Douglas P., Cawthon, Peggy M., Dam, Thuy-Tien L., Ferrucci, Luigi, Guralnik, Jack M., Kritchevsky, Stephen B., Vassileva, Maria T., Gudnason, Vilmunder, Eiriksdottir, Gudny, Koster, Annemarie, Newman, Anne, Siggeirsdottir, Kristin, Satterfield, Suzanne, Studenski, Stephanie A., Kenny, Anne M.

“…Objectives To compare the relative predictive power of handgrip and leg extension strength in predicting slow walking. Design Report of correlative analysis…”
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The relationship between visual function and physical performance in the Study of Muscle, Mobility and Aging (SOMMA) by Thompson, Atalie C, Johnson, Eileen, Miller, Michael E, Williamson, Jeff D, Newman, Anne B, Cummings, Steve, Cawthon, Peggy, Kritchevsky, Stephen B

“…Purpose The relationship of types of visual function to different aspects of physical function, especially strength and coordination, has been understudied,…”
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Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women by Fox, Caroline S, Liu, Yongmei, White, Charles C, Feitosa, Mary, Smith, Albert V, Heard-Costa, Nancy, Lohman, Kurt, Johnson, Andrew D, Foster, Meredith C, Greenawalt, Danielle M, Griffin, Paula, Ding, Jinghong, Newman, Anne B, Tylavsky, Fran, Miljkovic, Iva, Kritchevsky, Stephen B, Launer, Lenore, Garcia, Melissa, Eiriksdottir, Gudny, Carr, J Jeffrey, Gudnason, Vilmunder, Harris, Tamara B, Cupples, L Adrienne, Borecki, Ingrid B

“…Body fat distribution, particularly centralized obesity, is associated with metabolic risk above and beyond total adiposity. We performed genome-wide…”
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Bone Mineral Density and Fracture Risk in Older Individuals with CKD by Robert H. Yenchek, Joachim H. Ix, Michael G. Shlipak, Douglas C. Bauer, Nahid J. Rianon, Stephen B. Kritchevsky, Tamara B. Harris, Anne B. Newman, Jane A. Cauley, Linda F. Fried, for the Health, Aging, and Body Composition Study

“…Kidney Disease Improving Global Outcomes guidelines recommend against bone mineral density (BMD) screening in CKD patients with mineral bone disease, due to a…”
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Impact of Intensive Lifestyle Intervention on Disability-Free Life Expectancy: The Look AHEAD Study by Gregg, Edward W, Lin, Ji, Bardenheier, Barbara, Chen, Haiying, Rejeski, W Jack, Zhuo, Xiaohui, Hergenroeder, Andrea L, Kritchevsky, Stephen B, Peters, Anne L, Wagenknecht, Lynne E, Ip, Edward H, Espeland, Mark A

“…The impact of weight loss intervention on disability-free life expectancy in adults with diabetes is unknown. We examined the impact of a long-term weight loss…”
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