Search Results - "Stephen, Hecht"

Lung carcinogenesis by tobacco smoke by Hecht, Stephen S.

“…Cigarette smoke is a complex mixture of chemicals including multiple genotoxic lung carcinogens. The classic mechanisms of carcinogen metabolic activation to…”
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Carcinogenic components of tobacco and tobacco smoke: A 2022 update by Li, Yupeng, Hecht, Stephen S.

“…Tobacco and tobacco smoke contain a complex mixture of over 9500 chemical compounds, many of which have been recognized as hazardous to human health by…”
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Smokeless tobacco and cigarette smoking: chemical mechanisms and cancer prevention by Hecht, Stephen S., Hatsukami, Dorothy K.

“…Tobacco products present a deadly combination of nicotine addiction and carcinogen exposure resulting in millions of cancer deaths per year worldwide. A…”
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Metabolic Activation and DNA Interactions of Carcinogenic N -Nitrosamines to Which Humans Are Commonly Exposed by Li, Yupeng, Hecht, Stephen S

“…Carcinogenic -nitrosamine contamination in certain drugs has recently caused great concern and the attention of regulatory agencies. These carcinogens-widely…”
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Biochemical Verification of Tobacco Use and Abstinence: 2019 Update by Benowitz, Neal L, Bernert, John T, Foulds, Jonathan, Hecht, Stephen S, Jacob, Peyton, Jarvis, Martin J, Joseph, Anne, Oncken, Cheryl, Piper, Megan E

“…Abstract Background The changing prevalence and patterns of tobacco use, the advent of novel nicotine delivery devices, and the development of new biomarkers…”
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Metabolism and DNA Adduct Formation of Tobacco-Specific N -Nitrosamines by Li, Yupeng, Hecht, Stephen S

“…The tobacco-specific -nitrosamines 4-( -nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) and '-nitrosonornicotine (NNN) always occur together and exclusively…”
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Oral Cell DNA Adducts as Potential Biomarkers for Lung Cancer Susceptibility in Cigarette Smokers by Hecht, Stephen S

“…This perspective considers the use of oral cell DNA adducts, together with exposure and genetic information, to potentially identify those cigarette smokers at…”
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Exposure and Metabolic Activation Biomarkers of Carcinogenic Tobacco-Specific Nitrosamines by Hecht, Stephen S, Stepanov, Irina, Carmella, Steven G

“…Lung cancer is the leading cause of cancer death in the world, and cigarette smoking is its main cause. Oral cavity cancer is another debilitating and often…”
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Identification of an N′-Nitrosonornicotine-Specific Deoxyadenosine Adduct in Rat Liver and Lung DNA by Li, Yupeng, Hecht, Stephen S

“…The tobacco-specific nitrosamines N′-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) are considered to be two of the most…”
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Mass Spectrometric Quantitation of N '-Nitrosonornicotine-1 N -oxide in the Urine of Cigarette Smokers and Smokeless Tobacco Users by Li, Yupeng, Hecht, Stephen S

“…'-Nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), which always occur together and are present exclusively in tobacco…”
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Mass Spectrometric Quantitation of N′‑Nitrosonornicotine‑1N‑oxide in the Urine of Cigarette Smokers and Smokeless Tobacco Users by Li, Yupeng, Hecht, Stephen S.

“…N′-Nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), which always occur together and are present exclusively in tobacco…”
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DNA damage in human oral cells induced by use of e-cigarettes by Guo, Jiehong, Hecht, Stephen S

“…The use of electronic cigarettes (e-cigarettes) has increased rapidly in the United States, especially among high school students. e-Cigarettes contain some…”
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Recent Studies on DNA Adducts Resulting from Human Exposure to Tobacco Smoke by Ma, Bin, Stepanov, Irina, Hecht, Stephen S

“…DNA adducts are believed to play a central role in the induction of cancer in cigarette smokers and are proposed as being potential biomarkers of cancer risk…”
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Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis by Smith, Martyn T, Guyton, Kathryn Z, Gibbons, Catherine F, Fritz, Jason M, Portier, Christopher J, Rusyn, Ivan, DeMarini, David M, Caldwell, Jane C, Kavlock, Robert J, Lambert, Paul F, Hecht, Stephen S, Bucher, John R, Stewart, Bernard W, Baan, Robert A, Cogliano, Vincent J, Straif, Kurt

“…A recent review by the International Agency for Research on Cancer (IARC) updated the assessments of the > 100 agents classified as Group 1, carcinogenic to…”
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Faster liquid chromatography-tandem mass spectrometry method for analysis of isomeric urinary mercapturic acid metabolites of crotonaldehyde, methacrolein, and methyl vinyl ketone by Chen, Menglan, Carmella, Steven G., Zhao, Yingchun, Hecht, Stephen S.

“…•Improved method to separate and quantify isomeric urinary mercapturic acids.•Crotonaldehyde, methacrolein, and methyl vinyl ketone MAs by LC-MS/MS in…”
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Quantitative Liquid Chromatography–Nanoelectrospray Ionization–High-Resolution Tandem Mass Spectrometry Analysis of Acrolein-DNA Adducts and Etheno-DNA Adducts in Oral Cells from Cigarette Smokers and Nonsmokers by Paiano, Viviana, Maertens, Laura, Guidolin, Valeria, Yang, Jing, Balbo, Silvia, Hecht, Stephen S

“…Cigarette smoking is an important source of human exposure to toxicants and carcinogens and contributes significantly to cancer morbidity and mortality…”
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Analysis of Acrolein-Derived 1, N2-Propanodeoxyguanosine Adducts in Human Lung DNA from Smokers and Nonsmokers by Yang, Jing, Balbo, Silvia, Villalta, Peter W, Hecht, Stephen S

“…Acrolein, the simplest α,β-unsaturated aldehyde, is present in relatively large quantities in cigarette smoke, and several studies have raised the possibility…”
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It is time to regulate carcinogenic tobacco-specific nitrosamines in cigarette tobacco by Hecht, Stephen S

“…The Family Smoking Prevention and Tobacco Control Act gives the U.S. Food and Drug Administration power to regulate tobacco products. This commentary calls for…”
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Liquid Chromatography-Nanoelectrospray Ionization-High-Resolution Tandem Mass Spectrometry Analysis of Apurinic/Apyrimidinic Sites in Oral Cell DNA of Cigarette Smokers, e-Cigarette Users, and Nonsmokers by Guo, Jiehong, Ikuemonisan, Joshua, Hatsukami, Dorothy K, Hecht, Stephen S

“…Cigarette smoking is an established risk factor for oral cancer. The health effects of e-cigarettes are still under investigation but may disturb oral cavity…”
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Research on cruciferous vegetables, indole-3-carbinol, and cancer prevention: A tribute to Lee W. Wattenberg by Fujioka, Naomi, Fritz, Vincent, Upadhyaya, Pramod, Kassie, Fekadu, Hecht, Stephen S.

“…Lee W. Wattenberg, who spent his entire career at the University of Minnesota, was a true pioneer in the field of chemoprevention. This paper is a tribute to…”
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