Search Results - "Stephan Gruber"

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    Multilayer chromosome organization through DNA bending, bridging and extrusion by Gruber, Stephan

    Published in Current opinion in microbiology (01-12-2014)
    “…Highlights • Bacterial nucleoids are compact, dynamic and highly organized structures. • Abundant DNA bending proteins cause local folding of chromosomal DNA…”
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    Journal Article
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    Ground subsidence and heave over permafrost: hourly time series reveal interannual, seasonal and shorter-term movement caused by freezing, thawing and water movement by Gruber, Stephan

    Published in The cryosphere (30-04-2020)
    “…Heave and subsidence of the ground surface can offer insight into processes of heat and mass transfer in freezing and thawing soils. Additionally, subsidence…”
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    Kite Proteins: a Superfamily of SMC/Kleisin Partners Conserved Across Bacteria, Archaea, and Eukaryotes by Palecek, Jan J., Gruber, Stephan

    Published in Structure (London) (01-12-2015)
    “…SMC/kleisin complexes form elongated annular structures, which are critical for chromosome segregation, genome maintenance, and the regulation of gene…”
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    Recruitment of Condensin to Replication Origin Regions by ParB/SpoOJ Promotes Chromosome Segregation in B. subtilis by Gruber, Stephan, Errington, Jeff

    Published in Cell (15-05-2009)
    “…Proper segregation of DNA replication products is essential in all cells. In Bacillus subtilis, two protein complexes have been implicated in this process: the…”
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    Environmental controls of frost cracking revealed through in situ acoustic emission measurements in steep bedrock by Girard, Lucas, Gruber, Stephan, Weber, Samuel, Beutel, Jan

    Published in Geophysical research letters (16-05-2013)
    “…Frost cracking, the breakdown of rock by freezing, is one of the most important mechanical weathering processes acting on Earth's surface. Insights on the…”
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    DNA tension-modulated translocation and loop extrusion by SMC complexes revealed by molecular dynamics simulations by Nomidis, Stefanos K, Carlon, Enrico, Gruber, Stephan, Marko, John F

    Published in Nucleic acids research (20-05-2022)
    “…Structural Maintenance of Chromosomes (SMC) complexes play essential roles in genome organization across all domains of life. To determine how the activities…”
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    DNA-segment-capture model for loop extrusion by structural maintenance of chromosome (SMC) protein complexes by Marko, John F, De Los Rios, Paolo, Barducci, Alessandro, Gruber, Stephan

    Published in Nucleic acids research (26-07-2019)
    “…Cells possess remarkable control of the folding and entanglement topology of long and flexible chromosomal DNA molecules. It is thought that structural…”
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    Transient DNA Occupancy of the SMC Interarm Space in Prokaryotic Condensin by Vazquez Nunez, Roberto, Ruiz Avila, Laura B., Gruber, Stephan

    Published in Molecular cell (25-07-2019)
    “…Multi-subunit SMC ATPases control chromosome superstructure and DNA topology, presumably by DNA translocation and loop extrusion. Chromosomal DNA is entrapped…”
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    Kinematics of steep bedrock permafrost by Hasler, Andreas, Gruber, Stephan, Beutel, Jan

    “…The mechanisms that control climate‐dependent rockfall from permafrost mountain slopes are currently poorly understood. In this study, we present the results…”
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    Closing the cohesin ring: Structure and function of its Smc3-kleisin interface by Gligoris, Thomas G., Scheinost, Johanna C., Bürmann, Frank, Petela, Naomi, Chan, Kok-Lung, Uluocak, Pelin, Beckouët, Frédéric, Gruber, Stephan, Nasmyth, Kim, Löwe, Jan

    “…Through their association with a kleisin subunit (Scc1), cohesin's Smc1 and Smc3 subunits are thought to form tripartite rings that mediate sister chromatid…”
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    Design analysis of a hybrid storage concept combining Ruths steam storage and latent thermal energy storage by Dusek, Sabrina, Hofmann, René, Gruber, Stephan

    Published in Applied energy (01-10-2019)
    “…[Display omitted] •New hybrid thermal energy storage concept for storing steam and electrical energy.•Analysis by variation of number and properties of…”
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    VirB, a transcriptional activator of virulence in Shigella flexneri, uses CTP as a cofactor by Antar, Hammam, Gruber, Stephan

    Published in Communications biology (25-11-2023)
    “…VirB is a transcriptional activator of virulence in the gram-negative bacterium Shigella flexneri encoded by the large invasion plasmid, pINV. It counteracts…”
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    Structure of Full-Length SMC and Rearrangements Required for Chromosome Organization by Diebold-Durand, Marie-Laure, Lee, Hansol, Ruiz Avila, Laura B., Noh, Haemin, Shin, Ho-Chul, Im, Haeri, Bock, Florian P., Bürmann, Frank, Durand, Alexandre, Basfeld, Alrun, Ham, Sihyun, Basquin, Jérôme, Oh, Byung-Ha, Gruber, Stephan

    Published in Molecular cell (20-07-2017)
    “…Multi-subunit SMC complexes control chromosome superstructure and promote chromosome disjunction, conceivably by actively translocating along DNA double…”
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    Transferring Cryosphere Knowledge between Mountains Globally: A Case Study of Western Canadian Mountains, the European Alps and the Scandes by Stewart-Jones, Emilie, Gruber, Stephan

    Published in Revue de géographie alpine (01-01-2023)
    “…Permafrost is present in mountains globally, yet most research has been focussed in the small area covered by the European Alps. This paper presents a method…”
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    Direct observation of a crescent-shape chromosome in expanded Bacillus subtilis cells by Tišma, Miloš, Bock, Florian Patrick, Kerssemakers, Jacob, Antar, Hammam, Japaridze, Aleksandre, Gruber, Stephan, Dekker, Cees

    Published in Nature communications (28-03-2024)
    “…Bacterial chromosomes are folded into tightly regulated three-dimensional structures to ensure proper transcription, replication, and segregation of the…”
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    Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding by Taschner, Michael, Basquin, Jérôme, Steigenberger, Barbara, Schäfer, Ingmar B, Soh, Young‐Min, Basquin, Claire, Lorentzen, Esben, Räschle, Markus, Scheltema, Richard A, Gruber, Stephan

    Published in The EMBO journal (02-08-2021)
    “…Eukaryotic cells employ three SMC (structural maintenance of chromosomes) complexes to control DNA folding and topology. The Smc5/6 complex plays roles in DNA…”
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    SMC is recruited to oriC by ParB and promotes chromosome segregation in Streptococcus pneumoniae by Minnen, Anita, Attaiech, Laetitia, Thon, Maria, Gruber, Stephan, Veening, Jan‐Willem

    Published in Molecular microbiology (01-08-2011)
    “…Summary Segregation of replicated chromosomes is an essential process in all organisms. How bacteria, such as the oval‐shaped human pathogen Streptococcus…”
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