Search Results - "Stephan Becker"

Assembly and transport of filovirus nucleocapsids by Dolnik, Olga, Becker, Stephan

“…Filovirus-infected cells are characterized by typical cytoplasmic inclusion bodies (IBs) located in the perinuclear region. The formation of these IBs is…”
Get full text

Ebola virus proteins NP, VP35, and VP24 are essential and sufficient to mediate nucleocapsid transport by Takamatsu, Yuki, Kolesnikova, Larissa, Becker, Stephan

“…The intracytoplasmic movement of nucleocapsids is a crucial step in the life cycle of enveloped viruses. Determination of the viral components necessary for…”
Get full text

Dynamic Phosphorylation of VP30 Is Essential for Ebola Virus Life Cycle by Biedenkopf, Nadine, Lier, Clemens, Becker, Stephan

“…Ebola virus is the causative agent of a severe fever with high fatality rates in humans and nonhuman primates. The regulation of Ebola virus transcription and…”
Get full text

Longitudinal Isolation of Potent Near-Germline SARS-CoV-2-Neutralizing Antibodies from COVID-19 Patients by Kreer, Christoph, Zehner, Matthias, Weber, Timm, Ercanoglu, Meryem S., Gieselmann, Lutz, Rohde, Cornelius, Halwe, Sandro, Korenkov, Michael, Schommers, Philipp, Vanshylla, Kanika, Di Cristanziano, Veronica, Janicki, Hanna, Brinker, Reinhild, Ashurov, Artem, Krähling, Verena, Kupke, Alexandra, Cohen-Dvashi, Hadas, Koch, Manuel, Eckert, Jan Mathis, Lederer, Simone, Pfeifer, Nico, Wolf, Timo, Vehreschild, Maria J.G.T., Wendtner, Clemens, Diskin, Ron, Gruell, Henning, Becker, Stephan, Klein, Florian

“…The SARS-CoV-2 pandemic has unprecedented implications for public health, social life, and the world economy. Because approved drugs and vaccines are limited…”
Get full text

Structure and assembly of the Ebola virus nucleocapsid by Wan, William, Kolesnikova, Larissa, Clarke, Mairi, Koehler, Alexander, Noda, Takeshi, Becker, Stephan, Briggs, John A. G.

“…Application of cryo-electron tomography and subtomogram averaging to determine the structure of the Ebola virus nucleocapsid within intact viruses and…”
Get full text

Dynamic phosphorylation of Ebola virus VP30 in NP-induced inclusion bodies by Lier, Clemens, Becker, Stephan, Biedenkopf, Nadine

“…Zaire Ebolavirus (EBOV) causes a severe feverish disease with high case fatality rates. Transcription of EBOV is dependent on the activity of the nucleocapsid…”
Get full text

Multi-level inhibition of coronavirus replication by chemical ER stress by Shaban, Mohammed Samer, Müller, Christin, Mayr-Buro, Christin, Weiser, Hendrik, Meier-Soelch, Johanna, Albert, Benadict Vincent, Weber, Axel, Linne, Uwe, Hain, Torsten, Babayev, Ilya, Karl, Nadja, Hofmann, Nina, Becker, Stephan, Herold, Susanne, Schmitz, M. Lienhard, Ziebuhr, John, Kracht, Michael

“…Coronaviruses (CoVs) are important human pathogens for which no specific treatment is available. Here, we provide evidence that pharmacological reprogramming…”
Get full text

Live-cell imaging of Marburg virus-infected cells uncovers actin-dependent transport of nucleocapsids over long distances by Schudt, Gordian, Kolesnikova, Larissa, Dolnik, Olga, Sodeik, Beate, Becker, Stephan

“…Transport of large viral nucleocapsids from replication centers to assembly sites requires contributions from the host cytoskeleton via cellular adaptor and…”
Get full text

The Integrity of the YxxL Motif of Ebola Virus VP24 Is Important for the Transport of Nucleocapsid-Like Structures and for the Regulation of Viral RNA Synthesis by Takamatsu, Yuki, Kolesnikova, Larissa, Schauflinger, Martin, Noda, Takeshi, Becker, Stephan

“…While it is well appreciated that late domains in the viral matrix proteins are crucial to mediate efficient virus budding, little is known about roles of late…”
Get full text

Functional Characterization of Adaptive Mutations during the West African Ebola Virus Outbreak by Dietzel, Erik, Schudt, Gordian, Krähling, Verena, Matrosovich, Mikhail, Becker, Stephan

“…The Ebola virus (EBOV) outbreak in West Africa started in December 2013, claimed more than 11,000 lives, threatened to destabilize a whole region, and showed…”
Get full text

Impact of Fatigue on Ergonomic Risk Scores and Foot Kinetics: A Field Study Employing Inertial and In-Shoe Plantar Pressure Measurement Devices by Simon, Steven, Dully, Jonas, Dindorf, Carlo, Bartaguiz, Eva, Becker, Stephan, Fröhlich, Michael

“…(1) Background: Occupational fatigue is a primary factor leading to work-related musculoskeletal disorders (WRMSDs). Kinematic and kinetic experimental studies…”
Get full text

Human Cell Tropism and Innate Immune System Interactions of Human Respiratory Coronavirus EMC Compared to Those of Severe Acute Respiratory Syndrome Coronavirus by Zielecki, Florian, Weber, Michaela, Eickmann, Markus, Spiegelberg, Larissa, Zaki, Ali Moh, Matrosovich, Mikhail, Becker, Stephan, Weber, Friedemann

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

The Ebola Virus Nucleoprotein Recruits the Host PP2A-B56 Phosphatase to Activate Transcriptional Support Activity of VP30 by Kruse, Thomas, Biedenkopf, Nadine, Hertz, Emil Peter Thrane, Dietzel, Erik, Stalmann, Gertrud, López-Méndez, Blanca, Davey, Norman E., Nilsson, Jakob, Becker, Stephan

“…Transcription of the Ebola virus genome depends on the viral transcription factor VP30 in its unphosphorylated form, but the underlying molecular mechanism of…”
Get full text

The effect of dose on the safety and immunogenicity of the VSV Ebola candidate vaccine: a randomised double-blind, placebo-controlled phase 1/2 trial by Huttner, Angela, MD, Dayer, Julie-Anne, MD, Yerly, Sabine, MSc, Combescure, Christophe, PhD, Auderset, Floriane, PhD, Desmeules, Jules, Prof, Eickmann, Markus, PhD, Finckh, Axel, Prof, Goncalves, Ana Rita, PhD, Hooper, Jay W, PhD, Kaya, Gürkan, MD, Krähling, Verena, PhD, Kwilas, Steve, PhD, Lemaître, Barbara, MSc, Matthey, Alain, MD, Silvera, Peter, PhD, Becker, Stephan, Prof, Fast, Patricia E, MD, Moorthy, Vasee, MD, Kieny, Marie Paule, PhD, Kaiser, Laurent, Prof, Siegrist, Claire-Anne, Prof

“…Summary Background Safe and effective vaccines against Ebola could prevent or control outbreaks. The safe use of replication-competent vaccines requires a…”
Get full text

Severe Ebola virus disease with vascular leakage and multiorgan failure: treatment of a patient in intensive care by Wolf, Timo, MD, Kann, Gerrit, Becker, Stephan, Prof, Stephan, Christoph, MD, Brodt, Hans-Reinhardt, MD, de Leuw, Philipp, MD, Grünewald, Thomas, MD, Vogl, Thomas, MD, Kempf, Volkhard A J, Prof, Keppler, Oliver T, Prof, Zacharowski, Kai, Prof

“…Summary Background In the current epidemic of Ebola virus disease in western Africa, many aid workers have become infected. Some of these aid workers have been…”
Get full text

Transport of Ebolavirus Nucleocapsids Is Dependent on Actin Polymerization: Live-Cell Imaging Analysis of Ebolavirus-Infected Cells by Schudt, Gordian, Dolnik, Olga, Kolesnikova, Larissa, Biedenkopf, Nadine, Herwig, Astrid, Becker, Stephan

“…Background. Transport of ebolavirus (EBOV) nucleocapsids from perinuclear viral inclusions, where they are formed, to the site of budding at the plasma…”
Get full text

Marburg virus inclusions: A virus-induced microcompartment and interface to multivesicular bodies and the late endosomal compartment by Dolnik, Olga, Stevermann, Lea, Kolesnikova, Larissa, Becker, Stephan

“…Filovirus infection of target cells leads to the formation of virally induced cytoplasmic inclusions that contain viral nucleocapsids at different stages of…”
Get full text

Inhibition of Rab1B Impairs Trafficking and Maturation of SARS-CoV-2 Spike Protein by Veeck, Christopher, Biedenkopf, Nadine, Rohde, Cornelius, Becker, Stephan, Halwe, Sandro

“…Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) utilizes cellular trafficking pathways to process its structural proteins and move them to the…”
Get full text

Inclusion Bodies Are a Site of Ebolavirus Replication by HOENEN, Thomas, SHABMAN, Reed S, GROSETH, Allison, HERWIG, Astrid, WEBER, Michaela, SCHUDT, Gordian, DOLNIK, Olga, BASIER, Christopher F, BECKER, Stephan, FELDMANN, Heinz

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Investigating the zoonotic origin of the West African Ebola epidemic by Marí Saéz, Almudena, Weiss, Sabrina, Nowak, Kathrin, Lapeyre, Vincent, Zimmermann, Fee, Düx, Ariane, Kühl, Hjalmar S, Kaba, Moussa, Regnaut, Sebastien, Merkel, Kevin, Sachse, Andreas, Thiesen, Ulla, Villányi, Lili, Boesch, Christophe, Dabrowski, Piotr W, Radonić, Aleksandar, Nitsche, Andreas, Leendertz, Siv Aina J, Petterson, Stefan, Becker, Stephan, Krähling, Verena, Couacy‐Hymann, Emmanuel, Akoua‐Koffi, Chantal, Weber, Natalie, Schaade, Lars, Fahr, Jakob, Borchert, Matthias, Gogarten, Jan F, Calvignac‐Spencer, Sébastien, Leendertz, Fabian H

“…The severe Ebola virus disease epidemic occurring in West Africa stems from a single zoonotic transmission event to a 2‐year‐old boy in Meliandou, Guinea. We…”
Get full text