Synthesis and antimicrobial evaluation of novel polyheterocyclic systems derived from cyclopenta[4',5']pyrido[3',2':4,5]furo[3,2-d]pyrimidine

The synthesis of new cyclopenta[4',5']pyrido[3',2':4,5]furo[3,2- d ]pyrimidin-7-amines have been carried out to study their antimicrobial activity. The biological tests evidenced that some of the synthesized compounds exhibit pronounced antimicrobial properties. A study of the st...

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Bibliographic Details
Published in:	Chemistry of heterocyclic compounds (New York, N.Y. 1965) Vol. 57; no. 1; pp. 75 - 80
Main Authors:	Sirakanyan, Samvel N., Spinelli, Domenico, Geronikaki, Athina, Kartsev, Victor G., Stepanyan, Hrachya M., Hakobyan, Elmira K., Hovakimyan, Anush A.
Format:	Journal Article
Language:	English
Published:	New York Springer US 01-01-2021 Springer Springer Nature B.V
Subjects:	Amines Antiinfectives and antibacterials Antimicrobial agents Biological activity Chemistry Chemistry and Materials Science Organic Chemistry Pharmacy Pyrimidines Synthesis Tetrazoles pyrimidin-7-amines furo[2,3 7-azidofuro[3,2 Dimroth rearrangement cyclopenta[4',5']pyrido[3',2':4,5]furo[3,2 antimicrobial activity pyrimidine 1,2,4]triazolo[4,3 azide-tetrazole equilibrium
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Summary:	The synthesis of new cyclopenta[4',5']pyrido[3',2':4,5]furo[3,2- d ]pyrimidin-7-amines have been carried out to study their antimicrobial activity. The biological tests evidenced that some of the synthesized compounds exhibit pronounced antimicrobial properties. A study of the structure–activity relationship revealed that the 3,5-dimethyl-1 H -pyrazol-1-yl moiety linked to the carbon C-9 of the pyrimidine plays a decisive role in the manifestation of activity. The influence of 3,5-dimethyl-1 H -pyrazol-1-yl group on the Dimroth rearrangement and azide-tetrazole equilibrium has also been examined.
ISSN:	0009-3122 1573-8353
DOI:	10.1007/s10593-021-02870-1