Search Results - "Stepakov, Alexander V"

Identification of Spiro-Fused Pyrrolo[3,4- a ]pyrrolizines and Tryptanthrines as Potential Antitumor Agents: Synthesis and In Vitro Evaluation by Latypova, Diana K, Shmakov, Stanislav V, Pechkovskaya, Sofya A, Filatov, Alexander S, Stepakov, Alexander V, Knyazev, Nickolay A, Boitsov, Vitali M

“…A series of heterocyclic compounds containing a spiro-fused pyrrolo[3,4- ]pyrrolizine and tryptanthrin framework have been synthesized and studied as potential…”
Get full text

Identification of Spiro-Fused [3-azabicyclo[3.1.0]hexane]oxindoles as Potential Antitumor Agents: Initial In Vitro Evaluation of Anti-Proliferative Effect and Actin Cytoskeleton Transformation in 3T3 and 3T3-SV40 Fibroblast by Knyazev, Nickolay A, Shmakov, Stanislav V, Pechkovskaya, Sofya A, Filatov, Alexander S, Stepakov, Alexander V, Boitsov, Vitali M, Filatova, Natalia A

“…Novel heterocyclic compounds containing 3-spiro[3-azabicyclo[3.1.0]hexane]oxindole framework ( , and ) have been studied as potential antitumor agents. The in…”
Get full text

11H-Benzo[4,5]imidazo[1,2-a]indol-11-one as a New Precursor of Azomethine Ylides: 1,3-Dipolar Cycloaddition Reactions with Cyclopropenes and Maleimides by Filatov, Alexander S., Pronina, Yulia A., Selivanov, Stanislav I., Shmakov, Stanislav V., Uspenski, Anton A., Boitsov, Vitali M., Stepakov, Alexander V.

“…The possibility of generating azomethine ylides from 11H-benzo[4,5]imidazo[1,2-a]indol-11-one and amino acids is shown for the first time. Based on the…”
Get full text

Biological Evaluation of 3-Azaspiro[Bicyclo[3.1.0]Hexane-2,5′-Pyrimidines] as Potential Antitumor Agents by Shmakov, Stanislav V., Latypova, Diana K., Shmakova, Tatiana V., Rubinshtein, Artem A., Chukin, Mark V., Zhuravskii, Sergei G., Knyazev, Nickolay A., Stepakov, Alexander V., Galagudza, Michael M., Boitsov, Vitali M.

“…A series of heterocyclic compounds containing spirofused barbiturate and 3-azabicyclo[3.1.0]hexane frameworks have been studied as potential antitumor agents…”
Get full text

Synthesis of bis-spirocyclic derivatives of 3-azabicyclo[3.1.0]hexane via cyclopropene cycloadditions to the stable azomethine ylide derived from Ruhemann's purple by Filatov, Alexander S, Khoroshilova, Olesya V, Larina, Anna G, Boitsov, Vitali M, Stepakov, Alexander V

“…A reliable method for the synthesis of bis-spirocyclic derivatives of 3-azabicyclo[3.1.0]hexanes through the 1,3-dipolar cycloaddition (1,3-DC) reactions of…”
Get full text

Stereo- and Regioselective 1,3-Dipolar Cycloaddition of the Stable Ninhydrin-Derived Azomethine Ylide to Cyclopropenes: Trapping of Unstable Cyclopropene Dipolarophiles by Filatov, Alexander S, Wang, Siqi, Khoroshilova, Olesya V, Lozovskiy, Stanislav V, Larina, Anna G, Boitsov, Vitali M, Stepakov, Alexander V

“…A stereo- and regioselective 1,3-dipolar cycloaddition of the stable ninhydrin-derived azomethine ylide…”
Get full text

Synthesis of Functionalized 3‑Spiro[cyclopropa[a]pyrrolizine]- and 3‑Spiro[3-azabicyclo[3.1.0]hexane]oxindoles from Cyclopropenes and Azomethine Ylides via [3 + 2]-Cycloaddition by Filatov, Alexander S, Knyazev, Nickolay A, Molchanov, Alexander P, Panikorovsky, Taras L, Kostikov, Rafael R, Larina, Anna G, Boitsov, Vitali M, Stepakov, Alexander V

“…3-Spiro­[cyclopropa­[a]­pyrrolizine]- and 3-spiro­[3-aza­bicyclo­[3.1.0]­hexane]­oxindoles were prepared in moderate to high yields via one-pot three-component…”
Get full text

Diastereomers of Cyclopropa[a]pyrrolizine Spiro-fused with a Benzo[4,5]imidazo[1,2-a]indole Fragment: Structure Determinations Using NMR Methods by Pronina, Yulia A., Stepakov, Alexander V., Popova, Ekaterina A., Boitsov, Vitali M., Baichurin, Ruslan I., Selivanov, Stanislav I.

“…NMR spectroscopy methods have been used to prove structures of two diastereomers of cyclopropa[ a ]pyrrolizine spiro-fused with a benzo[4,5]imidazo[1,2- a…”
Get full text

NMR Study of Spatial Structure and Internal Dynamic of Adducts of Ninhydrin-Derived Azomethine Ylide with Cyclopropenes by Selivanov, Stanislav I., Wang, Siqi, Filatov, Alexander S., Stepakov, Alexander V.

“…Using NMR spectroscopy, the structure of the new products obtained in reaction of ninhydrin-derived azomethine ylide with cyclopropenes was established and…”
Get full text

Regioisomers of 2,5,6,7,8-Pentaaryl-1H-Azepino[3,2,1-ij]Quinazoline-1,3(2H)-Dione Containing Various Aryl Substituents in the Azepine Ring: Structure Determination Using NMR Methods by Pronina, Julia A., Komolova, Darya D., Boitsov, Vitali M., Stepakov, Alexander V., Selivanov, Stanislav I.

“…NMR spectroscopy methods were used to prove the structures of two similar regioisomers of 2,5,6,7,8-pentaaryl-1 H -azepino[3,2,1- ij ]quinazoline-1,3(2 H…”
Get full text

A highly efficient [3+2] cycloaddition of nitrile oxides and azomethine imines to N-vinylpyrroles by Efremova, Mariia M., Molchanov, Alexander P., Stepakov, Alexander V., Kostikov, Rafael R., Shcherbakova, Victoriya S., Ivanov, Andrey V.

“…1,3-Dipolar cycloaddition of various nitrile oxides to substituted N-vinylpyrroles proceed with high efficiency and selectivity with the formation of single…”
Get full text

[3+2] Cycloaddition reactions of arylallenes with C-(N-arylcarbamoyl)- and C,C-bis(methoxycarbonyl)nitrones and subsequent rearrangements by Malinina, Julia, Tran, Tung Q., Stepakov, Alexander V., Gurzhiy, Vladislav V., Starova, Galina L., Kostikov, Rafael R., Molchanov, Alexander P.

“…The first example of 1,3-dipolar cycloaddition reactions of nitrones with arylallenes is described. C-Carbamoylnitrones react with the C1C2 double bond of…”
Get full text

Synthesis of indene derivatives via reactions of vinylidenecyclopropanes with the N-acyliminium cations generated from hydroxylactams by Stepakov, Alexander V., Larina, Anna G., Boitsov, Vitaly M., Gurzhiy, Vladislav V., Molchanov, Alexander P., Kostikov, Rafael R.

“…A novel route for the synthesis of 1H-indene derivatives via the reactions of vinylidenecyclopropanes (VCPs) with the N-acyliminium cations generated from…”
Get full text

Acid-induced rearrangement of cycloadducts from N-aryl itaconimides and 1,3-diphenylisobenzofuran by Stepakov, Alexander V., Boitsov, Vitaly M., Larina, Anna G., Molchanov, Alexander P.

“…Treatment of several Diels–Alder adducts of N-aryl itaconimides and 1,3-diphenylisobenzofuran with a strong acid triggers a skeletal rearrangement resulting in…”
Get full text

Acid-Induced Rearrangement of Cycloadducts from Cyclopropenecarboxylates and 1,3-Diarylisobenzofurans by Efremova, Mariia M., Molchanov, Alexander P., Larina, Anna G., Starova, Galina L., Kostikov, Rafael R., Stepakov, Alexander V.

“…Treatment of several Diels–Alder adducts of cyclopropenecarboxylates and 1,3‐diarylisobenzofurans with a strong acid triggers a skeletal rearrangement…”
Get full text

Reactions of 1,1-diaryl-2-isopropylidene-3-methylenecyclopropanes with C,N-diarylnitrones and nitrile oxides by Stepakov, Alexander V., Larina, Anna G., Boitsov, Vitaly M., Molchanov, Alexander P., Gurzhiy, Vladislav V., Starova, Galina L.

“…The reactions of unactivated bis(methylene)cyclopropanes with nitrones and nitrile oxides have been investigated. The…”
Get full text

The first example of 1,3-dipolar cycloaddition reactions of nitrones to vinylidenecyclopropanes by Larina, Anna G., Stepakov, Alexander V., Boitsov, Vitaly M., Molchanov, Alexander P., Gurzhiy, Vladislav V., Starova, Galina L., Lykholay, Anna N.

“…The first example of 1,3-dipolar cycloaddition reactions of nitrones to vinylidenecyclopropanes is described. The nitrones react with the C1′–C2′ double bond…”
Get full text

A new approach to the synthesis of 4-( N-aryl)carbamoylmethyl-4,5-dihydropyridazin-3(2 H)-ones by Stepakov, Alexander V., Kinzhalov, Michail A., Boitsov, Vitaly M., Stepakova, Liubov V., Starova, Galina L., Vyazmin, Sergey Yu, Grinenko, Elena V.

“…Reaction of N-aryl substituted maleimides with aliphatic ketazines leads to the formation of 4,5-dihydropyridazin-3(2 H)-ones in moderate yields. The reaction…”
Get full text

Diastereoselective 1,3-dipolar cycloaddition of cyclopropenes to acenaphthenequinone azomethine ylides by Stepakov, Alexander V., Pronina, Yulia A., Filatov, Alexander S., Selivanov, Stanislav I., Kornev, Anton A., Kryukova, Mariya A., Ponyaev, Alexander I., Boitsov, Vitali M.

Get full text

Diastereoselective cycloaddition of tosylpropadiene to azomethine ylides, derived from proline and carbonyl compounds: an experimental and DFT study by Stepakov, Alexander V., Filatov, Alexander S., Boitsov, Vitali M., Lozovskiy, Stanislav V.

Get full text