Search Results - "Stensløkken, Kåre‐Olav"

Mitochondrial and mitochondrial‐independent pathways of myocardial cell death during ischaemia and reperfusion injury by Davidson, Sean M., Adameová, Adriana, Barile, Lucio, Cabrera‐Fuentes, Hector Alejandro, Lazou, Antigone, Pagliaro, Pasquale, Stensløkken, Kåre‐Olav, Garcia‐Dorado, David

“…Acute myocardial infarction causes lethal injury to cardiomyocytes during both ischaemia and reperfusion (IR). It is important to define the precise mechanisms…”
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Valve Interstitial Cells: The Key to Understanding the Pathophysiology of Heart Valve Calcification by Rutkovskiy, Arkady, Malashicheva, Anna, Sullivan, Gareth, Bogdanova, Maria, Kostareva, Anna, Stensløkken, Kåre‐Olav, Fiane, Arnt, Vaage, Jarle

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Mitochondria‐derived damage‐associated molecular patterns and inflammation in the ischemic‐reperfused heart by Torp, May‐Kristin, Vaage, Jarle, Stensløkken, Kåre‐Olav

“…Cardiac cell death after myocardial infarction release endogenous structures termed damage‐associated molecular patterns (DAMPs) that trigger the innate immune…”
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Inhibiting nucleolin reduces inflammation induced by mitochondrial DNA in cardiomyocytes exposed to hypoxia and reoxygenation by Mariero, Lars Henrik, Torp, May‐Kristin, Heiestad, Christina Mathisen, Baysa, Anton, Li, Yuchuan, Valen, Guro, Vaage, Jarle, Stensløkken, Kåre‐Olav

“…Background and purpose Cellular debris causes sterile inflammation after myocardial infarction. Mitochondria constitute about 30 percent of the human heart…”
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Differential production of mitochondrial reactive oxygen species between mouse (Mus musculus) and crucian carp (Carassius carassius) by Gerber, Lucie, Torp, May‐Kristin, Nilsson, Göran E., Lefevre, Sjannie, Stensløkken, Kåre‐Olav

“…Aim In most vertebrates, oxygen deprivation and subsequent re‐oxygenation are associated with mitochondrial impairment and excess production of reactive oxygen…”
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Early cardiac-chamber-specific fingerprints in heart failure with preserved ejection fraction detected by FTIR and Raman spectroscopic techniques by Tombolesi, Niki, Altara, Raffaele, da Silva, Gustavo J. J., Tannous, Cynthia, Zouein, Fouad A., Stensløkken, Kåre-Olav, Morresi, Assunta, Paolantoni, Marco, Booz, George W., Cataliotti, Alessandro, Sassi, Paola

“…The pathophysiology of heart failure with preserved ejection fraction (HFpEF) is a matter of investigation and its diagnosis remains challenging. Although the…”
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No knowledge gap in human physiology after remote teaching for second year medical students throughout the Covid-19 pandemic by Schauber, Stefan K, Stensløkken, Kåre-Olav

“…The COVID-19 pandemic had a disruptive effect on higher education. A critical question is whether these changes affected students' learning outcomes. Knowledge…”
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When Our Best Friend Becomes Our Worst Enemy: The Mitochondrion in Trauma, Surgery, and Critical Illness by Torp, May-Kristin, Stensløkken, Kåre-Olav, Vaage, Jarle

“…Common for major surgery, multitrauma, sepsis, and critical illness, is a whole-body inflammation. Tissue injury is able to trigger a generalized inflammatory…”
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Extreme anoxia tolerance in crucian carp and goldfish through neofunctionalization of duplicated genes creating a new ethanol-producing pyruvate decarboxylase pathway by Fagernes, Cathrine E., Stensløkken, Kåre-Olav, Røhr, Åsmund K., Berenbrink, Michael, Ellefsen, Stian, Nilsson, Göran E.

“…Without oxygen, most vertebrates die within minutes as they cannot meet cellular energy demands with anaerobic metabolism. However, fish of the genus Carassius…”
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Extracellular mtDNA activates NF-κB via toll-like receptor 9 and induces cell death in cardiomyocytes by Bliksøen, Marte, Mariero, Lars Henrik, Torp, May Kristin, Baysa, Anton, Ytrehus, Kirsti, Haugen, Fred, Seljeflot, Ingebjørg, Vaage, Jarle, Valen, Guro, Stensløkken, Kåre-Olav

“…Acute myocardial infarction (AMI) causes sterile inflammation, which exacerbates tissue injury. Elevated levels of circulating mitochondrial DNA (mtDNA) have…”
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Toll-like receptor 9 signaling after myocardial infarction: Role of p66ShcA adaptor protein by Baysa, Anton, Maghazachi, Azzam A., Sand, Kristin Larsen, Campesan, Marika, Zaglia, Tania, Mongillo, Marco, Giorgio, Marco, Di Lisa, Fabio, Gullestad, Lars, Mariero, Lars H., Vaage, Jarle, Valen, Guro, Stensløkken, Kåre-Olav

“…During myocardial infarction, cellular debris is released, causing a sterile inflammation via pattern recognition receptors. These reactions amplify damage and…”
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Isolated Plin5-deficient cardiomyocytes store less lipid droplets than normal, but without increased sensitivity to hypoxia by Li, Yuchuan, Torp, May-Kristin, Norheim, Frode, Khanal, Prabhat, Kimmel, Alan R., Stensløkken, Kåre-Olav, Vaage, Jarle, Dalen, Knut Tomas

“…Plin5 is abundantly expressed in the heart where it binds to lipid droplets (LDs) and facilitates physical interaction between LDs and mitochondria. We…”
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A Novel Ex Vivo Model of Aortic Valve Calcification. A Preliminary Report by Zabirnyk, Arsenii, Perez, Maria Del Mar, Blasco, Marc, Stensløkken, Kåre-Olav, Ferrer, Miguel D, Salcedo, Carolina, Vaage, Jarle

“…No pharmacological treatment exists to prevent or stop the calcification process of aortic valves causing aortic stenosis. The aim of this study was to develop…”
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Hyperglycemia-simulating environment attenuated experimentally induced calcification in cultured human aortic valve interstitial cells by Zabirnyk, Arsenii, Evensen, Daria, Kvitting, John-Peder Escobar, Kaljusto, Mari-Liis, Stensløkken, Kåre-Olav, Vaage, Jarle

“…The role of diabetes mellitus as a risk factor for the development of calcific aortic valve disease has not been fully clarified. Aortic valve interstitial…”
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Effects of hydrogen sulphide on ischaemia–reperfusion injury and ischaemic preconditioning in the isolated, perfused rat heart by Bliksøen, Marte, Kaljusto, Mari-Liis, Vaage, Jarle, Stensløkken, Kåre-Olav

“…Objective: Hydrogen sulphide (H2S) protects the heart against ischaemia–reperfusion injury caused by low flow or local ischaemia. We hypothesised that: (1) H2S…”
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Aquaporin-1 in cardiac endothelial cells is downregulated in ischemia, hypoxia and cardioplegia by Rutkovskiy, Arkady, Bliksøen, Marte, Hillestad, Vigdis, Amin, Mubashar, Czibik, Gabor, Valen, Guro, Vaage, Jarle, Amiry-Moghaddam, Mahmood, Stensløkken, Kåre-Olav

“…Abstract Aquaporin-1 (AQP1) is expressed in human and mouse hearts, but little is known about its cellular and subcellular localization and regulation. The aim…”
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Mammalian Target of Rapamycin (mTOR) and the Proteasome Attenuates IL-1β Expression in Primary Mouse Cardiac Fibroblasts by Torp, May-Kristin, Yang, Kuan, Ranheim, Trine, Husø Lauritzen, Knut, Alfsnes, Katrine, Vinge, Leif E, Aukrust, Pål, Stensløkken, Kåre-Olav, Yndestad, Arne, Sandanger, Øystein

“…IL-1β is a highly potent pro-inflammatory cytokine and its secretion is tightly regulated. Inactive pro-IL-1β is transcribed in response to innate immune…”
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Mechanical stress alters the expression of calcification-related genes in vascular interstitial and endothelial cells by Rutkovskiy, Arkady, Lund, Maria, Siamansour, Tanja Saman, Reine, Trine Marita, Kolset, Svein Olav, Sand, Kristin Larsen, Ignatieva, Elena, Gordeev, Mikhail L, Stensløkken, Kåre-Olav, Valen, Guro, Vaage, Jarle, Malashicheva, Anna

“…Abstract OBJECTIVES Vascular wall calcification is a major pathophysiological component of atherosclerotic disease with many similarities to osteogenesis…”
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Release of Mitochondrial and Nuclear DNA During On-Pump Heart Surgery: Kinetics and Relation to Extracellular Vesicles by Baysa, Anton, Fedorov, Anton, Kondratov, Kirill, Ruusalepp, Arno, Minasian, Sarkis, Galagudza, Michael, Popov, Maxim, Kurapeev, Dmitry, Yakovlev, Alexey, Valen, Guro, Kostareva, Anna, Vaage, Jarle, Stensløkken, Kåre-Olav

“…During heart surgery with cardiopulmonary bypass (CPB), the release of mitochondrial (mtDNA) and nuclear DNA (nDNA) and their association to extracellular…”
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Multi-omics of in vitro aortic valve calcification by Semenova, Daria, Zabirnyk, Arsenii, Lobov, Arseniy, Boyarskaya, Nadezda, Kachanova, Olga, Uspensky, Vladimir, Zainullina, Bozhana, Denisov, Evgeny, Gerashchenko, Tatiana, Kvitting, John-Peder Escobar, Kaljusto, Mari-Liis, Thiede, Bernd, Kostareva, Anna, Stensløkken, Kåre-Olav, Vaage, Jarle, Malashicheva, Anna

“…Heart valve calcification is an active cellular and molecular process that partly remains unknown. Osteogenic differentiation of valve interstitial cells (VIC)…”
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