Search Results - "Stensen, Signe"

GIP and the gut-bone axis – Physiological, pathophysiological and potential therapeutic implications by Stensen, Signe, Gasbjerg, Lærke Smidt, Helsted, Mads Marstrand, Hartmann, Bolette, Christensen, Mikkel Bring, Knop, Filip Krag

“…•The gut-derived peptide hormone GIP affects bone remodelling through an enteroendocrine-osseous axis.•In humans, exogenous and endogenous GIP reduce bone…”
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Separate and Combined Glucometabolic Effects of Endogenous Glucose-Dependent Insulinotropic Polypeptide and Glucagon-like Peptide 1 in Healthy Individuals by Gasbjerg, Lærke S., Helsted, Mads M., Hartmann, Bolette, Jensen, Mette H., Gabe, Maria B.N., Sparre-Ulrich, Alexander H., Veedfald, Simon, Stensen, Signe, Lanng, Amalie R., Bergmann, Natasha C., Christensen, Mikkel B., Vilsbøll, Tina, Holst, Jens J., Rosenkilde, Mette M., Knop, Filip K.

“…The incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are secreted postprandially and contribute…”
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Evaluation of the incretin effect in humans using GIP and GLP-1 receptor antagonists by Gasbjerg, Lærke S., Bergmann, Natasha C., Stensen, Signe, Christensen, Mikkel B., Rosenkilde, Mette M., Holst, Jens J., Nauck, Michael, Knop, Filip K.

“…•Using incretin hormone receptor antagonists, we can distinguish GIP and GLP-1 actions•In healthy men, the incretin effect amounts to ∼60-75%•Estimated from…”
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Endogenous Glucose-Dependent Insulinotropic Polypeptide Contributes to Sitagliptin-Mediated Improvement in Beta Cell Function in Patients with Type 2 Diabetes by Stensen, Signe, Gasbjerg, Lærke S., Rosenkilde, Mette M., Vilsbøll, Tina, Holst, Jens J., Hartmann, Bolette, Christensen, Mikkel B., Knop, Filip K.

“…Dipeptidyl peptidase 4 (DPP-4) degrades the incretin hormones glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). DPP-4…”
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Semaglutide Improves Cardiovascular Outcomes in Patients With History of Coronary Artery Bypass Graft and Obesity by Verma, Subodh, Emerson, Scott, Plutzky, Jorge, Kahn, Steven E., Stensen, Signe, Weeke, Peter E., Musinga, Derrick, Poirier, Paul, Lingvay, Ildiko, Lincoff, A. Michael

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The role of endogenous GIP and GLP-1 in postprandial bone homeostasis by Helsted, Mads M., Gasbjerg, Lærke S., Lanng, Amalie R., Bergmann, Natasha C., Stensen, Signe, Hartmann, Bolette, Christensen, Mikkel B., Holst, Jens J., Vilsbøll, Tina, Rosenkilde, Mette M., Knop, Filip K.

“…The incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are well known for their insulinotropic effects…”
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Factors associated with type‐specific persistence of high‐risk human papillomavirus infection: A population‐based study by Stensen, Signe, Kjaer, Susanne K., Jensen, Signe M., Frederiksen, Kirsten, Junge, Jette, Iftner, Thomas, Munk, Christian

“…Persistent genital infection with high‐risk (HR) human papillomavirus (HPV) is a prerequisite for cervical cancer development. The aim of this study was to…”
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Effects of endogenous GIP in patients with type 2 diabetes by Stensen, Signe, Gasbjerg, Lærke S, Krogh, Liva L, Skov-Jeppesen, Kirsa, Sparre-Ulrich, Alexander H, Jensen, Mette H, Dela, Flemming, Hartmann, Bolette, Vilsbøll, Tina, Holst, Jens J, Rosenkilde, Mette M, Christensen, Mikkel B, Knop, Filip K

“…Objective The insulinotropic effect of exogenous, intravenously infused glucose-dependent insulinotropic polypeptide (GIP) is impaired in patients with type 2…”
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GIP’s involvement in the pathophysiology of type 2 diabetes by Christensen, Mikkel B., Gasbjerg, Lærke S., Heimbürger, Sebastian M., Stensen, Signe, Vilsbøll, Tina, Knop, Filip K.

“…•Impaired insulinotropic effect of GIP occurs secondary to the development of diabetes.•GIP may further impair the weakened postprandial glucagon suppression…”
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Perceptions, behaviours and potential barriers to effective obesity care. Results from the ACTION‐DK study by Vilsbøll, Tina, Gribsholt, Sigrid Bjerge, Jørgensen, Nils Bruun, Andreassen, Pernille, Nielsen, Per, Yssing, Cecilie, Bøgelund, Mette, Stensen, Signe, Nørremark, Kasper, Bruun, Jens Meldgaard

“…Aim Weight bias, stigma and discrimination are pervasive in the health care system and society and may result in biased treatment of people living with obesity…”
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GIP and GLP-1 Receptor Antagonism During a Meal in Healthy Individuals by Gasbjerg, Lærke S, Helsted, Mads M, Hartmann, Bolette, Sparre-Ulrich, Alexander H, Veedfald, Simon, Stensen, Signe, Lanng, Amalie R, Bergmann, Natasha C, Christensen, Mikkel B, Vilsbøll, Tina, Holst, Jens J, Rosenkilde, Mette M, Knop, Filip K

“…Abstract Context The actions of both endogenous incretin hormones during a meal have not previously been characterized. Objective Using specific receptor…”
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The role of GLP-1 in the postprandial effects of acarbose in type 2 diabetes by Dalsgaard, Niels B, Gasbjerg, Lærke S, Hansen, Laura S, Hansen, Nina L, Stensen, Signe, Hartmann, Bolette, Rehfeld, Jens F, Holst, Jens J, Vilsbøll, Tina, Knop, Filip K

“…Aims The alpha-glucosidase inhibitor acarbose is believed to reduce plasma glucose by delaying hydrolysis of carbohydrates. Acarbose-induced transfer of…”
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The role of glucagon-like peptide 1 in the postprandial effects of metformin in type 2 diabetes: a randomized crossover trial by Hansen, Laura S, Gasbjerg, Lærke S, Brønden, Andreas, Dalsgaard, Niels B, Bahne, Emilie, Stensen, Signe, Hellmann, Pernille H, Rehfeld, Jens F, Hartmann, Bolette, Wever Albrechtsen, Nicolai J, Holst, Jens J, Vilsbøll, Tina, Knop, Filip K

“…Although metformin is widely used for treatment of type 2 diabetes (T2D), its glucose-lowering mechanisms remains unclear. Using the glucagon-like peptide 1…”
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85-LB: Glucose-Dependent Insulinotropic Polypeptide (GIP) Contributes Substantially to the Improved Beta-Cell Function during Sitagliptin Treatment in Persons with Type 2 Diabetes by STENSEN, SIGNE, GASBJERG, LÆRKE S., ROSENKILDE, METTE M., HARTMANN, BOLETTE, VILSBØLL, TINA, HOLST, JENS J., CHRISTENSEN, MIKKEL B., KNOP, FILIP K.

“…In persons with type 2 diabetes (T2D), dipeptidyl peptidase 4 (DPP-4) inhibitor treatment improves glycemic control by raising the active levels of the…”
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Acute concomitant glucose‐dependent insulinotropic polypeptide receptor antagonism during glucagon‐like peptide 1 receptor agonism does not affect appetite, resting energy expenditure or food intake in patients with type 2 diabetes and overweight/obesity by Stensen, Signe, Krogh, Liva L., Sparre‐Ulrich, Alexander H., Dela, Flemming, Hartmann, Bolette, Vilsbøll, Tina, Holst, Jens J., Rosenkilde, Mette M., Christensen, Mikkel B., Gasbjerg, Lærke S., Knop, Filip K.

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The naturally occurring GIP(1-30)NH2 is a GIP receptor agonist in humans by Krogh, Liva S L, Henriksen, Kristine, Stensen, Signe, Skov-Jeppesen, Kirsa, Bergmann, Natasha C, Størling, Joachim, Rosenkilde, Mette M, Hartmann, Bolette, Holst, Jens J, Gasbjerg, Lærke S, Knop, Filip K

“…The gut hormone glucose-dependent insulinotropic polypeptide (GIP) is an important regulator of glucose and bone metabolism. In rodents, the naturally…”
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357-OR: Improved Glycemic Control in Persons with Type 2 Diabetes Improves Beta-Cell Actions of Endogenous Glucose-Dependent Insulinotropic Polypeptide by HOE, BJØRN, LYNGGAARD, MADS B., GASBJERG, LÆRKE S., HELSTED, MADS M., STENSEN, SIGNE, HARTMANN, BOLETTE, HOLST, JENS J., CHRISTENSEN, MIKKEL B., VILSBØLL, TINA, KNOP, FILIP K.

“…The insulinotropic effect of exogenous glucose-dependent insulinotropic polypeptide (GIP) is severely reduced or even absent in persons with type 2 diabetes…”
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1362-P: Endogenous Glucose-Dependent Insulinotropic Polypeptide Facilitates Postprandial Intestinal Lipid Uptake in Healthy Men, but Not in Patients with Type 2 Diabetes by GASBJERG, LÆRKE S., HELSTED, MADS M., STENSEN, SIGNE, KROGH, LIVA S.L., SPARRE-ULRICH, ALEXANDER H., HARTMANN, BOLETTE, VILSBØLL, TINA, CHRISTENSEN, MIKKEL B., HOLST, JENS J., CHRISTOFFERSEN, CHRISTINA, KNOP, FILIP K., ROSENKILDE, METTE M.

“…The gut hormone glucose-dependent insulinotropic polypeptide (GIP) stimulates glucose-induced insulin secretion and increases triglyceride deposition in…”
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Dose‐dependent efficacy of the glucose‐dependent insulinotropic polypeptide (GIP) receptor antagonist GIP(3‐30)NH2 on GIP actions in humans by Gasbjerg, Lærke Smidt, Bari, Emilie J., Stensen, Signe, Hoe, Bjørn, Lanng, Amalie R., Mathiesen, David S., Christensen, Mikkel B., Hartmann, Bolette, Holst, Jens J., Rosenkilde, Mette M., Knop, Filip Krag

“…The glucose‐dependent insulinotropic polypeptide (GIP) fragment GIP(3‐30)NH2 is a selective, competitive GIP receptor antagonist, and doses of 800 to 1200…”
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1145-P: Acarbose-Induced Glucagon-Like Peptide-1 Secretion Contributes to the Glucose-Lowering Effect of Acarbose by DALSGAARD, NIELS B., GASBJERG, LÆRKE S., HANSEN, LAURA S., HANSEN, NINA L., STENSEN, SIGNE, HARTMANN, BOLETTE, HOLST, JENS J., VILSBØLL, TINA, KNOP, FILIP K.

“…The glucose-lowering alpha-glucosidase inhibitor acarbose, is believed to act by delaying digestion and absorption of dietary carbohydrates. It has been shown…”
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