Search Results - "Stenovec, Matjaž"

Properties of Ca2+-dependent exocytosis in cultured astrocytes by Kreft, Marko, Stenovec, Matjaž, Rupnik, Marjan, Grilc, Sonja, Kržan, Mojca, Potokar, Maja, Pangršič, Tina, Haydon, Philip G., Zorec, Robert

“…Astrocytes, a subtype of glial cells, have numerous characteristics that were previously considered exclusive for neurons. One of these characteristics is a…”
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Ketamine Alters Functional Plasticity of Astroglia: An Implication for Antidepressant Effect by Stenovec, Matjaž

“…Ketamine, a non-competitive N–methyl–d–aspartate receptor (NMDAR) antagonist, exerts a rapid, potent and long-lasting antidepressant effect, although the…”
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Prolactin Secretion Sites Contain Syntaxin-1 and Differ from Ganglioside Monosialic Acid Rafts in Rat Lactotrophs by Gonçalves, Paula P, Stenovec, Matjaž, Chowdhury, Helena H, Grilc, Sonja, Kreft, Marko, Zorec, Robert

“…In neuroendocrine cells, discharge of hormones follows the fusion of exocytotic vesicles with the plasma membrane at confined sites; however, the molecular…”
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Astrocytes in rapid ketamine antidepressant action by Stenovec, Matjaž, Li, Baoman, Verkhratsky, Alexei, Zorec, Robert

“…Ketamine, a general anaesthetic and psychotomimetic drug, exerts rapid, potent and long-lasting antidepressant effect, albeit the cellular and molecular…”
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PKH26 labeling of extracellular vesicles: Characterization and cellular internalization of contaminating PKH26 nanoparticles by Pužar Dominkuš, Pia, Stenovec, Matjaž, Sitar, Simona, Lasič, Eva, Zorec, Robert, Plemenitaš, Ana, Žagar, Ema, Kreft, Marko, Lenassi, Metka

“…PKH lipophilic dyes are highly fluorescent and stain membranes by intercalating their aliphatic portion into the exposed lipid bilayer. They have established…”
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Exocytosis of large-diameter lysosomes mediates interferon γ-induced relocation of MHC class II molecules toward the surface of astrocytes by Božić, Mićo, Verkhratsky, Alexei, Zorec, Robert, Stenovec, Matjaž

“…Astrocytes are the key homeostatic cells in the central nervous system; initiation of reactive astrogliosis contributes to neuroinflammation. Pro-inflammatory…”
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Astroglial Mechanisms of Ketamine Action Include Reduced Mobility of Kir4.1-Carrying Vesicles by Stenovec, Matjaž, Božić, Mićo, Pirnat, Samo, Zorec, Robert

“…The finding that ketamine, an anaesthetic, can elicit a rapid antidepressant effect at low doses that lasts for weeks in patients with depression is arguably a…”
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Probing single molecule mechanical interactions of syntaxin 1A with native synaptobrevin 2 residing on a secretory vesicle by Liu, Wei, Stenovec, Matjaž, Lee, William, Montana, Vedrana, Kreft, Marko, Zorec, Robert, Parpura, Vladimir

“…•Secretory vesicles docked at the plasma membrane of lactotroph lawns.•Single-molecule force spectroscopy measurements combined with fluorescence…”
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Nestin Regulates Neurogenesis in Mice Through Notch Signaling From Astrocytes to Neural Stem Cells by Wilhelmsson, Ulrika, Lebkuechner, Isabell, Leke, Renata, Marasek, Pavel, Yang, Xiaoguang, Antfolk, Daniel, Chen, Meng, Mohseni, Paria, Lasič, Eva, Bobnar, Saša Trkov, Stenovec, Matjaž, Zorec, Robert, Nagy, Andras, Sahlgren, Cecilia, Pekna, Marcela, Pekny, Milos

“…The intermediate filament (nanofilament) protein nestin is a marker of neural stem cells, but its role in neurogenesis, including adult neurogenesis, remains…”
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The Association Between Antidepressant Effect of SSRIs and Astrocytes: Conceptual Overview and Meta‐analysis of the Literature by Chen, Beina, Zhang, Manman, Ji, Ming, Gong, Wenliang, Chen, Binjie, Zorec, Robert, Stenovec, Matjaž, Verkhratsky, Alexei, Li, Baoman

“…Major depressive disorders (MDD) a worldwide psychiatric disease, is yet to be adequately controlled by therapies; while the mechanisms of action of…”
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Astrocyte Specific Remodeling of Plasmalemmal Cholesterol Composition by Ketamine Indicates a New Mechanism of Antidepressant Action by Lasič, Eva, Lisjak, Marjeta, Horvat, Anemari, Božić, Mićo, Šakanović, Aleksandra, Anderluh, Gregor, Verkhratsky, Alexei, Vardjan, Nina, Jorgačevski, Jernej, Stenovec, Matjaž, Zorec, Robert

“…Ketamine is an antidepressant with rapid therapeutic onset and long-lasting effect, although the underlying mechanism(s) remain unknown. Using FRET-based…”
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Astrocyte arborization enhances Ca2+ but not cAMP signaling plasticity by Pirnat, Samo, Božić, Mićo, Dolanc, Dorian, Horvat, Anemari, Tavčar, Petra, Vardjan, Nina, Verkhratsky, Alexei, Zorec, Robert, Stenovec, Matjaž

“…The plasticity of astrocytes is fundamental for their principal function, maintaining homeostasis of the central nervous system throughout life, and is…”
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Expression of familial Alzheimer disease presenilin 1 gene attenuates vesicle traffic and reduces peptide secretion in cultured astrocytes devoid of pathologic tissue environment by Stenovec, Matjaž, Trkov, Saša, Lasič, Eva, Terzieva, Slavica, Kreft, Marko, Rodríguez Arellano, José Julio, Parpura, Vladimir, Verkhratsky, Alexei, Zorec, Robert

“…In the brain, astrocytes provide metabolic and trophic support to neurones. Failure in executing astroglial homeostatic functions may contribute to the…”
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Regulation of AQP4 surface expression via vesicle mobility in astrocytes by Potokar, Maja, Stenovec, Matjaž, Jorgačevski, Jernej, Holen, Torgeir, Kreft, Marko, Ottersen, Ole Petter, Zorec, Robert

“…Aquaporin 4 (AQP4) is the predominant water channel in the brain, expressed mainly in astrocytes and involved in water transport in physiologic and pathologic…”
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Calcium-dependent subquantal peptide release from single docked lawn-resident vesicles of pituitary lactotrophs by Gonçalves, Paula P., Stenovec, Matjaž, Grácio, Luciano, Kreft, Marko, Zorec, Robert

“…•A release-competent exocytotic apparatus is preserved in lactotroph lawns.•Stimulated peptide discharge from single vesicles is subquantal, and unitary or…”
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Dynamin regulates the fusion pore of endo- and exocytotic vesicles as revealed by membrane capacitance measurements by Lasič, Eva, Stenovec, Matjaž, Kreft, Marko, Robinson, Phillip J., Zorec, Robert

“…Dynamin is a multidomain GTPase exhibiting mechanochemical and catalytic properties involved in vesicle scission from the plasmalemma during endocytosis. New…”
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Subanesthetic doses of ketamine stabilize the fusion pore in a narrow flickering state in astrocytes by Lasič, Eva, Rituper, Boštjan, Jorgačevski, Jernej, Kreft, Marko, Stenovec, Matjaž, Zorec, Robert

“…Ketamine is an anesthetic that exhibits analgesic, psychotomimetic, and rapid antidepressant effects that are of particular neuropharmacological interest…”
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Nestin affects fusion pore dynamics in mouse astrocytes by Lasič, Eva, Trkov Bobnar, Saša, Wilhelmsson, Ulrika, Pablo, Yolanda, Pekny, Milos, Zorec, Robert, Stenovec, Matjaž

“…Aim Astrocytes play a homeostatic role in the central nervous system and influence numerous aspects of neurophysiology via intracellular trafficking of…”
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Intermediate filaments attenuate stimulation-dependent mobility of endosomes/lysosomes in astrocytes by Potokar, Maja, Stenovec, Matjaž, Gabrijel, Mateja, Li, Lizhen, Kreft, Marko, Grilc, Sonja, Pekny, Milos, Zorec, Robert

“…Intermediate filament (IF) proteins upregulation is a hallmark of astrocyte activation and reactive gliosis, but its pathophysiological implications remain…”
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Astrocytes Negatively Regulate Neurogenesis Through the Jagged1-Mediated Notch Pathway by Wilhelmsson, Ulrika, Faiz, Maryam, de Pablo, Yolanda, Sjöqvist, Marika, Andersson, Daniel, Widestrand, Åsa, Potokar, Maja, Stenovec, Matjaž, Smith, Peter L. P., Shinjyo, Noriko, Pekny, Tulen, Zorec, Robert, Ståhlberg, Anders, Pekna, Marcela, Sahlgren, Cecilia, Pekny, Milos

“…Adult neurogenesis is regulated by a number of cellular players within the neurogenic niche. Astrocytes participate actively in brain development, regulation…”
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