Search Results - "Stempak, J"

A validated web‐based tool to display individualised Crohn's disease predicted outcomes based on clinical, serologic and genetic variables by Siegel, C. A., Horton, H., Siegel, L. S., Thompson, K. D., Mackenzie, T., Stewart, S. K., Rice, P. W., Stempak, J. M., Dezfoli, S., Haritunians, T., Levy, A., Baek, M., Milgrom, R., Dulai, P. S., Targan, S. R., Silverberg, M. S., Dubinsky, M. C., McGovern, D. P.

“…Summary Background Early treatment for Crohn's disease (CD) with immunomodulators and/or anti‐TNF agents improves outcomes in comparison to a slower ‘step up’…”
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MAST3: a novel IBD risk factor that modulates TLR4 signaling by Labbé, C, Goyette, P, Lefebvre, C, Stevens, C, Green, T, Tello-Ruiz, M K, Cao, Z, Landry, A L, Stempak, J, Annese, V, Latiano, A, Brant, S R, Duerr, R H, Taylor, K D, Cho, J H, Steinhart, A H, Daly, M J, Silverberg, M S, Xavier, R J, Rioux, J D

“…Inflammatory bowel disease (IBD) is a chronic disorder caused by multiple factors in a genetically susceptible host. Significant advances in the study of…”
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The effect of dietary folate on genomic and p53-specific DNA methylation in rat colon by Sohn, Kyoung-Jin, Stempak, Joanne M., Reid, Sarah, Shirwadkar, Shaila, Mason, Joel B., Kim, Young-In

“…Folate is an important mediator in the transfer of methyl groups for DNA methylation, abnormalities of which are considered to play an important mechanistic…”
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P468 Relevance of anti-drug antibodies in context of supra-therapeutic anti-TNF concentrations by Kim, J, Walshe, M, Borowski, K, Milgrom, R, Stempak, J, Lee, S H, Croitoru, K, Silverberg, M S

“…Abstract Background The low serum concentration of anti-tumor necrosis factor-alpha (anti-TNFα) agents and the presence of anti-drug antibodies are related to…”
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Magnesium Dietary Intake Modulates Blood Lipid Levels and Atherogenesis by Altura, Bella T., Brust, Manfred, Bloom, Sherman, Barbour, Randall L., Stempak, Jerome G., Altura, Burton M.

“…In this study, we have examined the effects of variation in dietary Mg on the atherogenic process. Oral supplementation of rabbits fed a high cholesterol diet…”
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P708 Ileal involvement defined by Montreal classification in Crohn’s disease is associated with a distinct microbial composition in ileal and colonic mucosa by Hernandez-Rocha, C, Nayeri, S, Turpin, W, Borowski, K, Stempak, J, Silverberg, M S

“…Abstract Background The Montreal classification of inflammatory bowel disease (IBD) recognizes distinct subgroups based on location of disease, age at onset…”
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DOP06 Histologic activity in Ulcerative Colitis patients achieving endoscopic healing is associated with higher rate of relapse and a distinct mucosal microbial and transcriptional profile by Hernandez-Rocha, C, Turpin, W, Nayeri, S, Borowski, K, Stempak, J, Conner, J, Silverberg, M S

“…Abstract Background Histologic remission (HR) in ulcerative colitis (UC) has been associated with better clinical outcomes. However, this therapeutic target is…”
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Protein Zero, a Nervous System Adhesion Molecule, Triggers Epithelial Reversion in Host Carcinoma Cells by Doyle, Joseph P., Stempak, Jerome G., Cowin, Pamela, Colman, David R., D'Urso, Donatella

“…Protein zero ( P o) is the immunoglobulin gene superfamily glycoprotein that mediates the self-adhesion of the Schwann cell plasma membrane that yields compact…”
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OP40 Transcriptomic signature of response to vedolizumab in patients with moderate-to-severe ulcerative colitis: Results from an international, multicentre, retrospective cohort study by Linggi, B, Salas, A, Veny, M, Borowski, K, Silverberg, M S, Milgrom, R, Stempak, J, Boland, B, Eckmann, L, Smith, M I, Parker, C E, Jairath, V, Teft, W, Vande Casteele, N

“…Abstract Background Transcriptomic analysis has the potential to facilitate drug development and clinical decision making in inflammatory bowel disease…”
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A181 HIGHER CUMULATIVE HISTOLOGIC INFLAMMATORY BURDEN SCORE IS ASSOCIATED WITH THE RISK OF DEVELOPMENT OF COLORECTAL NEOPLASIA IN ULCERATIVE COLITIS by Graff, D, Hernandez-Rocha, C, Borowski, K, Stempak, J, Conner, J, Silverberg, M S

“…Abstract Background Ulcerative colitis (UC) patients have an elevated risk of colorectal neoplasia (CRN). Younger age at diagnosis, extent of colitis, and…”
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A156 MUCOSA-ASSOCIATED MICROBIOTA OF ILEOCOLONIC CROHN’S DISEASE PATIENTS IS DISTINCT FROM COLONIC CROHN’S DISEASE AND ULCERATIVE COLITIS PATIENTS INDEPENDENT OF BIOPSY SITE, ENDOSCOPIC INFLAMMATION AND HOST GENETICS by Hernandez-Rocha, C, Nayeri, S, Turpin, W, Borowski, K, Stempak, J, Silverberg, M S

“…Abstract Background Colonic IBD encompassing ulcerative colitis (UC) and isolated colonic Crohn’s disease (cCD) shows significant clinical, therapeutic…”
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A88 A PROSPECTIVE STUDY OF MECHANISMS OF INTESTINAL INFLAMMATION AFTER ILEAL RESECTION IN CROHN’S DISEASE: PRELIMINARY ANALYSIS OF PHENOTYPIC PREDICTORS OF ENDOSCOPIC RECURRENCE by Boland, K, Stempak, J, Silverberg, M S

“…Abstract Background Post-operative endoscopic recurrence of ileal Crohn’s Disease (CD) is common, however the evolution of disease recurrence over time…”
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P066 Lower serum concentration of sulfated bile acids is associated with Primary Sclerosing Cholangitis Inflammatory Bowel Disease comorbidity and advanced liver fibrosis by Leibovitzh, H, Nayeri, S, Borowski, K, Hernandez-Rocha, C, Lee, S H, Turpin, W, Stempak, J, Sandhu, I, Milgrom, R, Smith, M I, Croitoru, K, Hirschfield, G M, Gulamhusein, A, Silverberg, M S

“…Abstract Background Primary sclerosing cholangitis associated Inflammatory bowel disease (PSC-IBD) carries significant morbidity risk. Alterations in bile acid…”
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A26 USE OF DRUG-TOLERANT ASSAYS IN INFLAMMATORY BOWEL DISEASE; WHAT DOES IT TELL US? by Walshe, M, Borowski, K, Stempak, J, Silverberg, M S

“…Abstract Background Therapeutic drug monitoring helps guide decision making in the treatment of IBD with anti-TNF therapies. Unlike older assays, newer…”
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Protein zero of peripheral nerve myelin: biosynthesis, membrane insertion, and evidence for homotypic interaction by D'Urso, D, Brophy, P J, Staugaitis, S M, Gillespie, C S, Frey, A B, Stempak, J G, Colman, D R

“…Protein zero (P0), an integral membrane glycoprotein synthesized by Schwann cells, is the major glycoprotein of peripheral nerve myelin. The predicted…”
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A101 USTEKINUMAB LEVELS MEASURED DURING INDUCTION ARE ASSOCIATED WITH CLINICAL AND BIOCHEMICAL OUTCOMES AT WEEK 12 OF TREATMENT IN CROHN’S DISEASE by Walshe, M, Borowski, K, Boland, K, Rho, S, Stempak, J, Silverberg, M

“…Abstract Background Therapeutic drug monitoring (TDM) helps guide use of anti-TNF drugs in IBD patients. In addition, higher anti-TNF levels during induction…”
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A9 BACTERIAL BILE SALT HYDROLASE GENE ABUNDANCE IS ASSOCIATED WITH RORC GENE EXPRESSION IN INTESTINAL MUCOSA OF INFLAMMATORY DISEASE PATIENTS by Hernandez-Rocha, C, Borowski, K, Turpin, W, Smith, M, Stempak, J, Silverberg, M S

“…Abstract Background The role of gut microbes involved in bile acid metabolism and their impact on mucosal immune regulation is beginning to be appreciated. For…”
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A41 LOSS OF SATB2 EXPRESSION IN COLORECTAL CANCER IS ASSOCIATED WITH DURATION OF INFLAMMATORY BOWEL DISEASE by Atin, J, Hernandez-Rocha, C, Borowski, K, Stempak, J, Smith, M, Conner, J R, Silverberg, M

“…Abstract Background Patients with inflammatory bowel disease (IBD) are at higher risk for developing colitis-associated colorectal cancer (CAC). Clinical and…”
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A161 MUCOSAL TRANSCRIPTOMICS IN NON-INFLAMED ILEUM OF CROHN’S DISEASE PATIENTS SHOWS DIFFERENTIALLY EXPRESSED GENE PROFILE COMPARED TO ILEUM OF HEALTHY CONTROLS by Martinez-Lozano, H, Nayeri, S, Borowski, K, Olivera Sendra, P A, Leibovitzh, H, Hernandez-Rocha, C, Lee, S, Stempak, J, Silverberg, M S

“…Abstract Background The terminal ileum is the most susceptible location to develop Crohn’s disease (CD) and therefore is a valuable tissue to investigate…”
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Conducting Translational Gastrointestinal Research in the Era of COVID-19 by Nayeri, Shadi, Walshe, Margaret, Lee, Sun-Ho, Filice, Melissa, Rho, Stella, Jeyakumar, Ajani, Stempak, Joanne, Smith, Michelle I, Silverberg, Mark S

“…Abstract Spread of the novel coronavirus SARS-CoV-2 has resulted in a global pandemic that is affecting the health and economy of all World Health Organization…”
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