Search Results - "Stellari, Fabio"

Modeling pulmonary fibrosis through bleomycin delivered by osmotic minipump: a new histomorphometric method of evaluation by Ravanetti, Francesca, Ragionieri, Luisa, Ciccimarra, Roberta, Ruscitti, Francesca, Pompilio, Daniela, Gazza, Ferdinando, Villetti, Gino, Cacchioli, Antonio, Stellari, Fabio F

“…The systemic delivery of bleomycin (BLM) to mice through subcutaneously implanted osmotic minipumps may be used to experimentally mimic the typical features of…”
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SSC-ILD mouse model induced by osmotic minipump delivered bleomycin: effect of Nintedanib by Ravanetti, Francesca, Ferrini, Erica, Ragionieri, Luisa, Khalajzeyqami, Zahra, Nicastro, Maria, Ridwan, Yanto, Kleinjan, Alex, Villetti, Gino, Grandi, Andrea, Stellari, Franco Fabio

“…Systemic sclerosis (SSc) is an autoimmune disease characterized by an excessive production and accumulation of collagen in the skin and internal organs often…”
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CHF6001 Inhibits NF-κB Activation and Neutrophilic Recruitment in LPS-Induced Lung Inflammation in Mice by Stellari, Fabio F, Sala, Angelo, Ruscitti, Francesca, Buccellati, Carola, Allen, Andrew, Risé, Patrizia, Civelli, Maurizio, Villetti, Gino

“…Inhibitors of phosphodiesterase 4 (PDE4) are potent anti-inflammatory agents, inhibiting the production of inflammatory mediators through the elevation of…”
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Red-shifted click beetle luciferase mutant expands the multicolor bioluminescent palette for deep tissue imaging by Zambito, Giorgia, Hall, Mary P., Wood, Monika G., Gaspar, Natasa, Ridwan, Yanto, Stellari, Fabio F., Shi, Ce, Kirkland, Thomas A., Encell, Lance P., Löwik, Clemens, Mezzanotte, Laura

“…For in vivo multicolor bioluminescence applications, red and near-infrared signals are desirable over shorter wavelength signals because they are not as…”
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Generation and characterization of the first immortalized alpaca cell line suitable for diagnostic and immunization studies by Franceschi, Valentina, Jacca, Sarah, Sassu, Elena L, Stellari, Fabio F, van Santen, Vicky L, Donofrio, Gaetano

“…Raising of alpacas as exotic livestock for wool and meat production and as companion animals is growing in importance in the United States, Europe and…”
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In vivo imaging of early stage apoptosis by measuring real-time caspase-3/7 activation by Scabini, Matteo, Stellari, Fabio, Cappella, Paolo, Rizzitano, Sara, Texido, Gemma, Pesenti, Enrico

“…In vivo imaging of apoptosis in a preclinical setting in anticancer drug development could provide remarkable advantages in terms of translational medicine. So…”
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Micro-CT-derived ventilation biomarkers for the longitudinal assessment of pathology and response to therapy in a mouse model of lung fibrosis by Pennati, Francesca, Leo, Ludovica, Ferrini, Erica, Sverzellati, Nicola, Bernardi, Davide, Stellari, Franco Fabio, Aliverti, Andrea

“…Experimental in-vivo animal models are key tools to investigate the pathogenesis of lung disease and to discover new therapeutics. Histopathological and…”
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Quantitative micro-CT-derived biomarkers elucidate age-related lung fibrosis in elder mice by Buseghin, Davide, Grandi, Andrea, Ferrini, Erica, Villetti, Gino, Ciccimarra, Roberta, Sverzellati, Nicola, Aliverti, Andrea, Pennati, Francesca, Stellari, Franco Fabio

“…Idiopathic Pulmonary Fibrosis (IPF), prevalently affecting individuals over 60 years of age, has been mainly studied in young mouse models. The limited…”
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In-vivo lung fibrosis staging in a bleomycin-mouse model: a new micro-CT guided densitometric approach by Mecozzi, Laura, Mambrini, Martina, Ruscitti, Francesca, Ferrini, Erica, Ciccimarra, Roberta, Ravanetti, Francesca, Sverzellati, Nicola, Silva, Mario, Ruffini, Livia, Belenkov, Sasha, Civelli, Maurizio, Villetti, Gino, Stellari, Fabio Franco

“…Although increasing used in the preclinical testing of new anti-fibrotic drugs, a thorough validation of micro-computed tomography (CT) in pulmonary fibrosis…”
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Pivotal role of micro-CT technology in setting up an optimized lung fibrosis mouse model for drug screening by Khalajzeyqami, Zahra, Grandi, Andrea, Ferrini, Erica, Ravanetti, Francesca, Leo, Ludovica, Mambrini, Martina, Giardino, Luciana, Villetti, Gino, Stellari, Franco Fabio

“…Idiopathic pulmonary fibrosis (IPF) is a progressive disease with no curative pharmacological treatment. The most used animal model of IPF for anti-fibrotic…”
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Micro-CT-assisted identification of the optimal time-window for antifibrotic treatment in a bleomycin mouse model of long-lasting pulmonary fibrosis by Buccardi, Martina, Grandi, Andrea, Ferrini, Erica, Buseghin, Davide, Villetti, Gino, Civelli, Maurizio, Sverzellati, Nicola, Aliverti, Andrea, Pennati, Francesca, Stellari, Franco Fabio

“…Idiopathic Pulmonary Fibrosis (IPF) is a debilitating and fatal lung disease characterized by the excessive formation of scar tissue and decline of lung…”
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A fully automated micro‑CT deep learning approach for precision preclinical investigation of lung fibrosis progression and response to therapy by Buccardi, Martina, Ferrini, Erica, Pennati, Francesca, Vincenzi, Elena, Ledda, Roberta Eufrasia, Grandi, Andrea, Buseghin, Davide, Villetti, Gino, Sverzellati, Nicola, Aliverti, Andrea, Stellari, Franco Fabio

“…Micro-computed tomography (µCT)-based imaging plays a key role in monitoring disease progression and response to candidate drugs in various animal models of…”
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Proteomic Fingerprint of Lung Fibrosis Progression and Response to Therapy in Bleomycin-Induced Mouse Model by Principi, Lucrezia, Ferrini, Erica, Ciccimarra, Roberta, Pagani, Lisa, Chinello, Clizia, Previtali, Paolo, Smith, Andrew, Villetti, Gino, Zoboli, Matteo, Ravanetti, Francesca, Stellari, Franco Fabio, Magni, Fulvio, Piga, Isabella

“…Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by the aberrant accumulation of extracellular matrix in the lungs. nintedanib is…”
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A fully automated deep learning pipeline for micro-CT-imaging-based densitometry of lung fibrosis murine models by Vincenzi, Elena, Fantazzini, Alice, Basso, Curzio, Barla, Annalisa, Odone, Francesca, Leo, Ludovica, Mecozzi, Laura, Mambrini, Martina, Ferrini, Erica, Sverzellati, Nicola, Stellari, Franco Fabio

“…Abstract Idiopathic pulmonary fibrosis, the archetype of pulmonary fibrosis (PF), is a chronic lung disease of a poor prognosis, characterized by progressively…”
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Quantification of Lung Fibrosis in IPF-Like Mouse Model and Pharmacological Response to Treatment by Micro-Computed Tomography by Ruscitti, Francesca, Ravanetti, Francesca, Bertani, Valeria, Ragionieri, Luisa, Mecozzi, Laura, Sverzellati, Nicola, Silva, Mario, Ruffini, Livia, Menozzi, Valentina, Civelli, Maurizio, Villetti, Gino, Stellari, Franco Fabio

“…Idiopathic pulmonary fibrosis (IPF) is a chronic progressive degenerative lung disease leading to respiratory failure and death. Although anti-fibrotic drugs…”
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Azithromycin inhibits nuclear factor‐κB activation during lung inflammation: an in vivo imaging study by Stellari, Fabio F., Sala, Angelo, Donofrio, Gaetano, Ruscitti, Francesca, Caruso, Paola, Topini, Thomas M., Francis, Kevin P., Li, Xiaojian, Carnini, Chiara, Civelli, Maurizio, Villetti, Gino

“…We studied in vivo the potential involvement of nuclear factor‐κB (NF‐κB) pathway in the molecular mechanism of the anti‐inflammatory and immunomodulatory…”
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The importance of routine quality control for reproducible pulmonary measurements by in vivo micro-CT by Mambrini, Martina, Mecozzi, Laura, Ferrini, Erica, Leo, Ludovica, Bernardi, Davide, Grandi, Andrea, Sverzellati, Nicola, Ruffini, Livia, Silva, Mario, Stellari, Franco Fabio

“…Micro-computed tomography (CT) imaging provides densitometric and functional assessment of lung diseases in animal models, playing a key role either in…”
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Enlightened Mannhemia haemolytica lung inflammation in bovinized mice by Stellari, Fabio Franco, Lavrentiadou, Sophia, Ruscitti, Francesca, Jacca, Sarah, Franceschi, Valentina, Civelli, Maurizio, Carnini, Chiara, Villetti, Gino, Donofrio, Gaetano

“…Polymorphonuclear cells diapedesis has an important contribution to the induced Mannhemia haemolytica (M. haemolytica) infection lung inflammation and IL-8 is…”
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Longitudinal assessment of bleomycin-induced lung fibrosis by Micro-CT correlates with histological evaluation in mice by Ruscitti, Francesca, Ravanetti, Francesca, Essers, Jeroen, Ridwan, Yanto, Belenkov, Sasha, Vos, Wim, Ferreira, Francisca, KleinJan, Alex, van Heijningen, Paula, Van Holsbeke, Cedric, Cacchioli, Antonio, Villetti, Gino, Stellari, Franco Fabio

“…The intratracheal instillation of bleomycin in mice induces early damage to alveolar epithelial cells and development of inflammation followed by fibrotic…”
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Alfaxalone and Dexmedetomidine as an Alternative to Gas Anesthesia for Micro-CT Lung Imaging in a Bleomycin-Induced Pulmonary Fibrosis Murine Model by Ferrini, Erica, Mecozzi, Laura, Corsi, Luisa, Ragionieri, Luisa, Donofrio, Gaetano, Stellari, Franco Fabio

“…Micro-CT imaging could be considered a powerful non-invasive tool for accessing pulmonary fibrosis in mice. However, the choice of the anesthesia protocol…”
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