Search Results - "Stella Man, Y K"

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  1. 1

    Systemic delivery and SPECT/CT in vivo imaging of 125I-labelled oncolytic adenoviral mutants in models of pancreatic cancer by Stella Man, Y. K., Foster, Julie, Carapuça, Elisabete, Davies, James A., Parker, Alan L., Sosabowski, Jane, Halldén, Gunnel

    Published in Scientific reports (06-09-2019)
    “…Early phase clinical trials have demonstrated good therapeutic index for oncolytic adenoviruses in patients with solid tumours when administered…”
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    Journal Article
  2. 2

    Hypoxia and its therapeutic possibilities in paediatric cancers by Bernauer, Carolina, Man, Y. K. Stella, Chisholm, Julia C., Lepicard, Elise Y., Robinson, Simon P., Shipley, Janet M.

    Published in British journal of cancer (02-02-2021)
    “…In tumours, hypoxia—a condition in which the demand for oxygen is higher than its availability—is well known to be associated with reduced sensitivity to…”
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    Journal Article
  3. 3

    The Novel Oncolytic Adenoviral Mutant Ad5-3Δ-A20T Retargeted to αvβ6 Integrins Efficiently Eliminates Pancreatic Cancer Cells by Man, Y K Stella, Davies, James A, Coughlan, Lynda, Pantelidou, Constantia, Blázquez-Moreno, Alfonso, Marshall, John F, Parker, Alan L, Halldén, Gunnel

    Published in Molecular cancer therapeutics (01-02-2018)
    “…Metastatic pancreatic ductal adenocarcinomas (PDAC) are incurable due to the rapid development of resistance to all current therapeutics. Oncolytic adenoviral…”
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    Journal Article
  4. 4

    Deafness-Associated Mutant Human Connexin 26 Improves the Epithelial Barrier In Vitro by Man, Y. K. Stella, Trolove, Caroline, Tattersall, Daniel, Thomas, Anna C, Papakonstantinopoulou, Annie, Patel, Drashnika, Scott, Claire, Chong, Jiehan, Jagger, Daniel J, O'Toole, Edel A, Navsaria, Harshad, Curtis, Michael A, Kelsell, David P

    Published in The Journal of membrane biology (01-08-2007)
    “…A large proportion of recessive nonsyndromic hearing loss is due to mutations in the GJB2 gene encoding connexin 26 (Cx26), a component of a gap junction…”
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    Journal Article
  5. 5

    Coating an adenovirus with functionalized gold nanoparticles favors uptake, intracellular trafficking and anti-cancer therapeutic efficacy by Gonzalez-Pastor, Rebeca, Hernandez, Yulan, Gimeno, Marina, de Martino, Alba, Man, Y.K. Stella, Hallden, Gunnel, Quintanilla, Miguel, de la Fuente, Jesus M, Martin-Duque, Pilar

    Published in Acta biomaterialia (15-10-2021)
    “…Adenoviral (Ad) vectors have proven to be important tools for gene and cell therapy, although some issues still need to be addressed, such as undesired…”
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    Journal Article
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  7. 7

    Targeted delivery of cytokine therapy to rheumatoid tissue by a synovial targeting peptide by Wythe, Sarah E, DiCara, Danielle, Taher, Taher E I, Finucane, Ciara M, Jones, Rita, Bombardieri, Michele, Man, Y K Stella, Nissim, Ahuva, Mather, Stephen J, Chernajovsky, Yuti, Pitzalis, Costantino

    Published in Annals of the rheumatic diseases (01-01-2013)
    “…The synovial endothelium targeting peptide (SyETP) CKSTHDRLC has been identified previously and was shown to preferentially localise to synovial xenografts in…”
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    Journal Article
  8. 8

    Structural guided scaffold phage display libraries as a source of bio-therapeutics by Man, Y K Stella, DiCara, Danielle, Chan, Nicole, Vessillier, Sandrine, Mather, Stephen J, Rowe, Michelle L, Howard, Mark J, Marshall, John F, Nissim, Ahuva

    Published in PloS one (09-08-2013)
    “…We have developed a structurally-guided scaffold phage display strategy for identification of ligand mimetic bio-therapeutics. As a proof of concept we used…”
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    Journal Article
  9. 9

    Poly(Amidoamine)s as Potential Nonviral Vectors:  Ability to Form Interpolyelectrolyte Complexes and to Mediate Transfection in Vitro by Richardson, Simon C. W, Pattrick, Nicola G, Stella Man, Y. K, Ferruti, Paolo, Duncan, Ruth

    Published in Biomacromolecules (2001)
    “…Poly(amidoamine)s (PAAs) are water-soluble polymers that display pH-dependent membrane activity. PAAs have the potential to act as a synthetic alternative to…”
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  10. 10
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    Sensitisation to mitoxantrone-induced apoptosis by the oncolytic adenovirus Ad∆∆ through Bcl-2-dependent attenuation of autophagy by Aguirre-Hernández, Carmen, Maya-Pineda, Héctor, Millán, Julia San, Man, Y. K. Stella, Lu, Yong-Jie, Halldén, Gunnel

    Published in Oncogenesis (New York, NY) (24-01-2018)
    “…Anti-apoptotic Bcl-2 is frequently activated in human malignant cells to promote cell survival and inhibit cell death. Replication-selective oncolytic…”
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    Journal Article
  12. 12

    Systemic delivery and SPECT/CT in vivo imaging of 125 I-labelled oncolytic adenoviral mutants in models of pancreatic cancer by Stella Man, Y K, Foster, Julie, Carapuça, Elisabete, Davies, James A, Parker, Alan L, Sosabowski, Jane, Halldén, Gunnel

    Published in Scientific reports (06-09-2019)
    “…Early phase clinical trials have demonstrated good therapeutic index for oncolytic adenoviruses in patients with solid tumours when administered…”
    Get full text
    Journal Article
  13. 13

    Modifying oncolytic viral therapy for pancreatic cancer by Man, Y.K. Stella, Pantelidou, Constantia, Blázquez-Moreno, Alfonso, Coughlan, Lynda, Marshall, John, Kocher, Hemant, Halldén, Gunnel

    “…Targeting avb6 -integrin expressing pancreatic cancer cells with oncolytic adenoviral mutants expressing a FMDV peptide (Ad5-FMDV): Diagnosis of pancreatic…”
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    Journal Article