Search Results - "Stella Man, Y K"
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Systemic delivery and SPECT/CT in vivo imaging of 125I-labelled oncolytic adenoviral mutants in models of pancreatic cancer
Published in Scientific reports (06-09-2019)“…Early phase clinical trials have demonstrated good therapeutic index for oncolytic adenoviruses in patients with solid tumours when administered…”
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2
Hypoxia and its therapeutic possibilities in paediatric cancers
Published in British journal of cancer (02-02-2021)“…In tumours, hypoxia—a condition in which the demand for oxygen is higher than its availability—is well known to be associated with reduced sensitivity to…”
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The Novel Oncolytic Adenoviral Mutant Ad5-3Δ-A20T Retargeted to αvβ6 Integrins Efficiently Eliminates Pancreatic Cancer Cells
Published in Molecular cancer therapeutics (01-02-2018)“…Metastatic pancreatic ductal adenocarcinomas (PDAC) are incurable due to the rapid development of resistance to all current therapeutics. Oncolytic adenoviral…”
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4
Deafness-Associated Mutant Human Connexin 26 Improves the Epithelial Barrier In Vitro
Published in The Journal of membrane biology (01-08-2007)“…A large proportion of recessive nonsyndromic hearing loss is due to mutations in the GJB2 gene encoding connexin 26 (Cx26), a component of a gap junction…”
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Coating an adenovirus with functionalized gold nanoparticles favors uptake, intracellular trafficking and anti-cancer therapeutic efficacy
Published in Acta biomaterialia (15-10-2021)“…Adenoviral (Ad) vectors have proven to be important tools for gene and cell therapy, although some issues still need to be addressed, such as undesired…”
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FGF7–FGFR2 autocrine signaling increases growth and chemoresistance of fusion‐positive rhabdomyosarcomas
Published in Molecular oncology (01-03-2022)“…Rhabdomyosarcomas are aggressive pediatric soft‐tissue sarcomas and include high‐risk PAX3–FOXO1 fusion‐gene‐positive cases. Fibroblast growth factor receptor…”
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Targeted delivery of cytokine therapy to rheumatoid tissue by a synovial targeting peptide
Published in Annals of the rheumatic diseases (01-01-2013)“…The synovial endothelium targeting peptide (SyETP) CKSTHDRLC has been identified previously and was shown to preferentially localise to synovial xenografts in…”
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Structural guided scaffold phage display libraries as a source of bio-therapeutics
Published in PloS one (09-08-2013)“…We have developed a structurally-guided scaffold phage display strategy for identification of ligand mimetic bio-therapeutics. As a proof of concept we used…”
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Poly(Amidoamine)s as Potential Nonviral Vectors: Ability to Form Interpolyelectrolyte Complexes and to Mediate Transfection in Vitro
Published in Biomacromolecules (2001)“…Poly(amidoamine)s (PAAs) are water-soluble polymers that display pH-dependent membrane activity. PAAs have the potential to act as a synthetic alternative to…”
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Autoantibody and T cell responses to oxidative post-translationally modified insulin neoantigenic peptides in type 1 diabetes
Published in Diabetologia (01-01-2023)“…Aims/hypothesis Antibodies specific to oxidative post-translational modifications (oxPTM) of insulin (oxPTM-INS) are present in most individuals with type 1…”
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Sensitisation to mitoxantrone-induced apoptosis by the oncolytic adenovirus Ad∆∆ through Bcl-2-dependent attenuation of autophagy
Published in Oncogenesis (New York, NY) (24-01-2018)“…Anti-apoptotic Bcl-2 is frequently activated in human malignant cells to promote cell survival and inhibit cell death. Replication-selective oncolytic…”
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Systemic delivery and SPECT/CT in vivo imaging of 125 I-labelled oncolytic adenoviral mutants in models of pancreatic cancer
Published in Scientific reports (06-09-2019)“…Early phase clinical trials have demonstrated good therapeutic index for oncolytic adenoviruses in patients with solid tumours when administered…”
Get full text
Journal Article -
13
Modifying oncolytic viral therapy for pancreatic cancer
Published in Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] (01-06-2016)“…Targeting avb6 -integrin expressing pancreatic cancer cells with oncolytic adenoviral mutants expressing a FMDV peptide (Ad5-FMDV): Diagnosis of pancreatic…”
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